ASB2 (ankyrin repeat and SOCS box containing 2) - Rat Genome Database

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Gene: ASB2 (ankyrin repeat and SOCS box containing 2) Canis lupus familiaris
Analyze
Symbol: ASB2
Name: ankyrin repeat and SOCS box containing 2
RGD ID: 12271234
Description: ENCODES a protein that exhibits cullin family protein binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN dendritic cell migration (ortholog); podosome assembly (ortholog); skeletal muscle atrophy (ortholog); ASSOCIATED WITH achondrogenesis type IA (ortholog); DICER1 syndrome (ortholog); pleuropulmonary blastoma (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); stress fiber (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ankyrin repeat and SOCS box protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,008,206 - 63,051,809 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,008,575 - 63,051,581 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha862,585,084 - 62,628,410 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0863,279,448 - 63,322,854 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,277,026 - 63,322,847 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1862,957,212 - 63,000,493 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,008,327 - 63,051,686 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,338,505 - 63,381,859 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ASB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,008,206 - 63,051,809 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,008,575 - 63,051,581 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha862,585,084 - 62,628,410 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0863,279,448 - 63,322,854 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,277,026 - 63,322,847 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1862,957,212 - 63,000,493 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,008,327 - 63,051,686 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,338,505 - 63,381,859 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ASB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381493,934,166 - 93,976,570 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1493,934,166 - 93,976,739 (-)Ensemblhg38GRCh38
GRCh371494,400,512 - 94,442,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,470,266 - 93,493,520 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341493,470,265 - 93,493,520NCBI
Celera1474,454,282 - 74,477,544 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1474,580,269 - 74,622,812 (-)NCBIHuRef
CHM1_11494,338,550 - 94,381,110 (-)NCBICHM1_1
T2T-CHM13v2.01488,161,475 - 88,203,881 (-)NCBIT2T-CHM13v2.0
Asb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912103,287,401 - 103,322,260 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12103,287,401 - 103,322,260 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812103,321,142 - 103,356,001 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12103,321,142 - 103,356,001 (-)Ensemblmm10GRCm38
MGSCv3712104,559,352 - 104,594,211 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612103,722,192 - 103,757,051 (-)NCBIMGSCv36mm8
Celera12104,538,189 - 104,572,686 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.9NCBI
Asb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,239,550 - 128,275,833 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,239,552 - 128,266,321 (-)EnsemblGRCr8
mRatBN7.26122,474,754 - 122,511,014 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,474,756 - 122,510,854 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6122,615,834 - 122,651,778 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06122,911,098 - 122,947,036 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,245,566 - 122,281,575 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,212,325 - 127,248,451 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,212,273 - 127,248,372 (-)Ensemblrn6Rnor6.0
Rnor_5.06136,425,783 - 136,469,502 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46127,609,500 - 127,645,492 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6119,956,026 - 119,991,593 (-)NCBICelera
RGSC_v3.16127,613,248 - 127,649,239 (-)NCBI
Cytogenetic Map6q32NCBI
Asb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543816,005,570 - 16,042,115 (-)Ensembl
ChiLan1.0NW_00495543816,005,570 - 16,041,668 (-)NCBIChiLan1.0ChiLan1.0
ASB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,091,860 - 95,134,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,308,365 - 94,350,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01474,566,607 - 74,608,905 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11493,900,425 - 93,942,764 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1493,900,914 - 93,930,527 (-)EnsemblpanPan2panpan1.1
Asb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864011,617,225 - 11,653,472 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367331,813,548 - 1,849,806 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367331,813,569 - 1,849,805 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,210,891 - 115,258,960 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17115,210,885 - 115,258,863 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27121,998,766 - 122,044,049 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12471,687,282 - 71,730,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2471,687,238 - 71,730,696 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605358,925,221 - 58,968,980 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473410,316,299 - 10,352,515 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473410,317,932 - 10,352,300 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in ASB2
752 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000027927   ⟹   ENSCAFP00000025970
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl863,008,575 - 63,051,581 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845004435   ⟹   ENSCAFP00845003547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl863,277,026 - 63,322,847 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845004460   ⟹   ENSCAFP00845003567
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl863,277,026 - 63,322,847 (-)Ensembl
RefSeq Acc Id: XM_005623755   ⟹   XP_005623812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1863,008,206 - 63,051,809 (-)NCBI
Dog10K_Boxer_Tasha862,585,084 - 62,628,410 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038484095   ⟹   XP_038340023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1862,957,212 - 63,000,493 (-)NCBI
RefSeq Acc Id: XM_038545602   ⟹   XP_038401530
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0863,338,505 - 63,381,859 (-)NCBI
RefSeq Acc Id: XM_038545603   ⟹   XP_038401531
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0863,338,505 - 63,381,859 (-)NCBI
RefSeq Acc Id: XM_038609698   ⟹   XP_038465626
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0863,008,327 - 63,051,686 (-)NCBI
RefSeq Acc Id: XM_038609699   ⟹   XP_038465627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0863,008,327 - 63,051,686 (-)NCBI
RefSeq Acc Id: XM_038674509   ⟹   XP_038530437
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0863,279,448 - 63,322,854 (-)NCBI
RefSeq Acc Id: XM_038674510   ⟹   XP_038530438
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0863,279,448 - 63,322,854 (-)NCBI
RefSeq Acc Id: XM_849378   ⟹   XP_854471
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1863,008,206 - 63,051,807 (-)NCBI
Dog10K_Boxer_Tasha862,585,084 - 62,628,410 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005623812   ⟸   XM_005623755
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LVE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_854471   ⟸   XM_849378
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KR09 (UniProtKB/TrEMBL),   A0A8I3MLV1 (UniProtKB/TrEMBL),   A0A8P0SM38 (UniProtKB/TrEMBL),   A0A8C0LVE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000025970   ⟸   ENSCAFT00000027927
RefSeq Acc Id: XP_038340023   ⟸   XM_038484095
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038465627   ⟸   XM_038609699
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038465626   ⟸   XM_038609698
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530438   ⟸   XM_038674510
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LVE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530437   ⟸   XM_038674509
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KR09 (UniProtKB/TrEMBL),   A0A8I3MLV1 (UniProtKB/TrEMBL),   A0A8P0SM38 (UniProtKB/TrEMBL),   A0A8C0LVE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401531   ⟸   XM_038545603
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LVE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401530   ⟸   XM_038545602
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KR09 (UniProtKB/TrEMBL),   A0A8C0LVE4 (UniProtKB/TrEMBL),   A0A8I3MLV1 (UniProtKB/TrEMBL),   A0A8P0SM38 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845003567   ⟸   ENSCAFT00845004460
Ensembl Acc Id: ENSCAFP00845003547   ⟸   ENSCAFT00845004435
Protein Domains
SOCS box

Promoters
RGD ID:13684318
Promoter ID:EPDNEW_C2385
Type:multiple initiation site
Name:ASB2_1
Description:ankyrin repeat and SOCS box containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1863,051,604 - 63,051,664EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017612 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000081 UniProtKB/TrEMBL
  ENSCAFG00845002504 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027927.6 UniProtKB/TrEMBL
  ENSCAFT00000096257.1 UniProtKB/TrEMBL
  ENSCAFT00030000099.1 UniProtKB/TrEMBL
  ENSCAFT00845004435.1 UniProtKB/TrEMBL
  ENSCAFT00845004460 ENTREZGENE
  ENSCAFT00845004460.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  SOCS box UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/TrEMBL
NCBI Gene ASB2 ENTREZGENE
PANTHER ANKYRIN REPEAT PROTEIN UniProtKB/TrEMBL
  GH09064P UniProtKB/TrEMBL
  SURFACE ANTIGEN BSPA-LIKE UniProtKB/TrEMBL
  SURFACE ANTIGEN BSPA-LIKE-RELATED UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Ank_3 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
UniProt A0A8C0KR09 ENTREZGENE
  A0A8C0LVE4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MLV1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RQR7_CANLF UniProtKB/TrEMBL
  A0A8P0SM38 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TJ46_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38163 ENTREZGENE