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Gene: AZIN2 (antizyme inhibitor 2) Canis lupus familiaris
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Symbol: AZIN2
Name: antizyme inhibitor 2
RGD ID: 12270391
Description: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). [provided by RefSeq, Sep 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADC; arginine decarboxylase
Orthologs:
Homo sapiens (human) : AZIN2 (antizyme inhibitor 2)  HGNC  Alliance
Mus musculus (house mouse) : Azin2 (antizyme inhibitor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Azin2 (antizyme inhibitor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Azin2 (antizyme inhibitor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AZIN2 (antizyme inhibitor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Azin2 (antizyme inhibitor 2)
Sus scrofa (pig) : AZIN2 (antizyme inhibitor 2)
Chlorocebus sabaeus (African green monkey) : AZIN2 (antizyme inhibitor 2)
Heterocephalus glaber (naked mole-rat) : Azin2 (antizyme inhibitor 2)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl268,286,195 - 68,323,710 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1268,288,554 - 68,323,710 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - uncurated

Genomics

Comparative Map Data

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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More on AZIN2
NCBI Gene
Ensembl Gene
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RGD Object Information
RGD ID: 12270391
Created: 2017-01-24
Species: Canis lupus familiaris
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.