MIR24-2 (microRNA mir-24-2) - Rat Genome Database

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Gene: MIR24-2 (microRNA mir-24-2) Canis lupus familiaris
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Symbol: MIR24-2
Name: microRNA mir-24-2 (Ensembl:microRNA 24-2)
RGD ID: 12269688
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-24-2; microRNA 24-2
RGD Orthologs
Human
Mouse
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,620,684 - 48,620,745 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,620,674 - 48,620,745 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2048,494,604 - 48,494,665 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02049,138,795 - 49,138,856 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,138,785 - 49,138,856 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,349,272 - 48,349,333 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,776,188 - 48,776,249 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,019,256 - 49,019,317 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to phenylalanine  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA)
myelination  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of sodium ion import across plasma membrane  (ISO)
negative regulation of type II interferon production  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
ossification  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
regulation of viral genome replication  (ISO)
retina vasculature development in camera-type eye  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18392026  


Genomics

Comparative Map Data
MIR24-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,620,684 - 48,620,745 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,620,674 - 48,620,745 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2048,494,604 - 48,494,665 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02049,138,795 - 49,138,856 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,138,785 - 49,138,856 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,349,272 - 48,349,333 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,776,188 - 48,776,249 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,019,256 - 49,019,317 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR24-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,836,287 - 13,836,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,836,287 - 13,836,359 (-)Ensemblhg38GRCh38
GRCh371913,947,101 - 13,947,173 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,808,100 - 13,808,172 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1913,840,849 - 13,840,921 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,518,669 - 13,518,741 (-)NCBIHuRef
CHM1_11913,947,606 - 13,947,678 (-)NCBICHM1_1
T2T-CHM13v2.01913,962,419 - 13,962,491 (-)NCBIT2T-CHM13v2.0
Mir24-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,935,444 - 84,935,550 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,935,444 - 84,935,550 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38884,208,815 - 84,208,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,208,815 - 84,208,921 (+)Ensemblmm10GRCm38
MGSCv37886,732,714 - 86,732,820 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera888,508,899 - 88,509,005 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.58NCBI
Mir24-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,859,455 - 40,859,562 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21923,954,683 - 23,954,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,954,683 - 23,954,790 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1930,775,543 - 30,775,650 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,429,952 - 31,430,059 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,652,721 - 33,652,828 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,318,863 - 25,318,970 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,318,863 - 25,318,970 (+)Ensemblrn6Rnor6.0
Rnor_5.01936,295,051 - 36,295,158 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1923,503,531 - 23,503,638 (-)NCBICelera
Cytogenetic Map19q11NCBI


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00000034996
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2048,620,674 - 48,620,745 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845047321
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2049,138,785 - 49,138,856 (+)Ensembl
RefSeq Acc Id: NR_049271
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12048,620,684 - 48,620,745 (+)NCBI
Dog10K_Boxer_Tasha2048,494,604 - 48,494,665 (+)NCBI
ROS_Cfam_1.02049,138,795 - 49,138,856 (+)NCBI
UMICH_Zoey_3.12048,349,272 - 48,349,333 (+)NCBI
UNSW_CanFamBas_1.02048,776,188 - 48,776,249 (+)NCBI
UU_Cfam_GSD_1.02049,019,256 - 49,019,317 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000022889 Ensembl
  ENSCAFG00845026849 Ensembl, ENTREZGENE
Ensembl Transcript ENSCAFT00845047321 ENTREZGENE
miRBase MI0008041 ENTREZGENE
NCBI Gene MIR24-2 ENTREZGENE
RNAcentral URS000045B66C RNACentral
  URS000075A200 RNACentral
  URS00007E3AB3 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR24-2  microRNA mir-24-2    microRNA 24-2  Symbol and/or name change 5135510 APPROVED