GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) - Rat Genome Database

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Gene: GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) Canis lupus familiaris
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Symbol: GRIN1
Name: glutamate ionotropic receptor NMDA type subunit 1
RGD ID: 12268259
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); calcium channel activity (ortholog); calcium ion binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); associative learning (ortholog); calcium ion homeostasis (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GluN1; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor ionotropic, NMDA 1; glutamate receptor subunit zeta 1; N-methyl-D-aspartate receptor 1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDAR1; NR1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,492,967 - 48,513,981 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,493,287 - 48,509,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,683,789 - 47,707,011 (-)NCBI
ROS_Cfam_1.0949,357,798 - 49,382,176 (-)NCBI
UMICH_Zoey_3.1948,135,045 - 48,158,254 (-)NCBI
UNSW_CanFamBas_1.0948,433,856 - 48,457,059 (-)NCBI
UU_Cfam_GSD_1.0948,481,015 - 48,504,246 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
associative learning  (ISO)
calcium ion homeostasis  (ISO)
calcium ion transmembrane import into cytosol  (ISO)
calcium ion transport  (ISO)
cation transport  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to manganese ion  (ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (IBA)
conditioned taste aversion  (ISO)
excitatory postsynaptic potential  (ISO)
ion transmembrane transport  (IEA)
ionotropic glutamate receptor signaling pathway  (IBA,ISO)
learning  (ISO)
learning or memory  (ISO)
long-term memory  (ISO)
male mating behavior  (ISO)
memory  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuromuscular process  (ISO)
olfactory learning  (ISO)
pons maturation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of Schwann cell migration  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (ISO)
propylene metabolic process  (ISO)
protein heterotetramerization  (ISS)
protein localization to postsynaptic membrane  (ISO)
protein-containing complex assembly  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell communication  (ISO)
regulation of dendrite morphogenesis  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of membrane potential  (IBA,ISO)
regulation of neuron apoptotic process  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of respiratory gaseous exchange  (ISO)
regulation of synapse assembly  (ISO)
regulation of synaptic plasticity  (ISO)
response to amine  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
response to ethanol  (ISO)
response to fungicide  (ISO)
response to glycine  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
rhythmic process  (ISO)
sensory perception of pain  (ISO)
social behavior  (ISO)
startle response  (ISO)
suckling behavior  (ISO)
synaptic transmission, glutamatergic  (ISO)
visual learning  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
GRIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,492,967 - 48,513,981 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,493,287 - 48,509,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,683,789 - 47,707,011 (-)NCBI
ROS_Cfam_1.0949,357,798 - 49,382,176 (-)NCBI
UMICH_Zoey_3.1948,135,045 - 48,158,254 (-)NCBI
UNSW_CanFamBas_1.0948,433,856 - 48,457,059 (-)NCBI
UU_Cfam_GSD_1.0948,481,015 - 48,504,246 (-)NCBI
GRIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9137,139,154 - 137,168,756 (+)EnsemblGRCh38hg38GRCh38
GRCh389137,139,092 - 137,168,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379140,033,606 - 140,063,208 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,153,430 - 139,183,029 (+)NCBINCBI36hg18NCBI36
Build 349137,308,678 - 137,339,043NCBI
Celera9110,548,072 - 110,577,040 (+)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9109,493,914 - 109,523,231 (+)NCBIHuRef
CHM1_19140,182,355 - 140,211,903 (+)NCBICHM1_1
Grin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,181,189 - 25,209,199 (-)NCBIGRCm39mm39
GRCm39 Ensembl225,181,193 - 25,209,199 (-)Ensembl
GRCm38225,291,177 - 25,319,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,291,181 - 25,319,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,146,697 - 25,174,683 (-)NCBIGRCm37mm9NCBIm37
MGSCv36225,114,256 - 25,140,988 (-)NCBImm8
Celera225,018,687 - 25,046,664 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.14NCBI
Grin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,103,680 - 8,130,603 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl38,103,680 - 8,130,603 (-)Ensembl
Rnor_6.032,507,745 - 2,534,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,506,896 - 2,534,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,489,158 - 2,516,082 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,453,784 - 3,480,381 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.133,453,783 - 3,480,381 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBICelera
Cytogenetic Map3p13NCBI
Grin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,154,864 - 5,178,636 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,154,864 - 5,178,636 (+)NCBIChiLan1.0ChiLan1.0
GRIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19137,168,543 - 137,198,297 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,168,722 - 137,197,382 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09108,198,350 - 108,228,887 (+)NCBIMhudiblu_PPA_v0panPan3
Grin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,536,077 - 202,560,723 (+)NCBI
SpeTri2.0NW_004936669814,330 - 838,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN1
(Sus scrofa - pig)
No map positions available.
GRIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,020,556 - 1,050,568 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl121,019,263 - 1,050,231 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660584,254,719 - 4,284,702 (+)NCBIVero_WHO_p1.0
Grin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624760777,208 - 800,525 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low 6 3 1 3
Below cutoff 5 5 14 4 6 4 6 5 3 7 7 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038675084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038675085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038675086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038675087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038675089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038675090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038675091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB195993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB195994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB195995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000031003   ⟹   ENSCAFP00000028837
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,493,287 - 48,509,050 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000031009   ⟹   ENSCAFP00000028842
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,493,287 - 48,509,050 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000044506   ⟹   ENSCAFP00000037473
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,493,287 - 48,509,050 (-)Ensembl
RefSeq Acc Id: NM_001008717   ⟹   NP_001008717
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,492,967 - 48,513,981 (-)NCBI
Dog10K_Boxer_Tasha947,683,789 - 47,707,011 (-)NCBI
ROS_Cfam_1.0949,358,634 - 49,381,888 (-)NCBI
UMICH_Zoey_3.1948,135,045 - 48,158,254 (-)NCBI
UNSW_CanFamBas_1.0948,433,856 - 48,457,059 (-)NCBI
UU_Cfam_GSD_1.0948,481,015 - 48,504,246 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038675084   ⟹   XP_038531012
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,358,786 - 49,382,176 (-)NCBI
RefSeq Acc Id: XM_038675085   ⟹   XP_038531013
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,357,798 - 49,381,888 (-)NCBI
RefSeq Acc Id: XM_038675086   ⟹   XP_038531014
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,358,954 - 49,382,176 (-)NCBI
RefSeq Acc Id: XM_038675087   ⟹   XP_038531015
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,358,786 - 49,382,028 (-)NCBI
RefSeq Acc Id: XM_038675089   ⟹   XP_038531017
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,357,798 - 49,381,888 (-)NCBI
RefSeq Acc Id: XM_038675090   ⟹   XP_038531018
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,358,954 - 49,381,888 (-)NCBI
RefSeq Acc Id: XM_038675091   ⟹   XP_038531019
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,358,634 - 49,381,888 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001008717   ⟸   NM_001008717
- Peptide Label: precursor
- UniProtKB: Q5R1P0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000028842   ⟸   ENSCAFT00000031009
RefSeq Acc Id: ENSCAFP00000028837   ⟸   ENSCAFT00000031003
RefSeq Acc Id: ENSCAFP00000037473   ⟸   ENSCAFT00000044506
RefSeq Acc Id: XP_038531017   ⟸   XM_038675089
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038531013   ⟸   XM_038675085
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038531019   ⟸   XM_038675091
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038531012   ⟸   XM_038675084
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038531015   ⟸   XM_038675087
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038531014   ⟸   XM_038675086
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038531018   ⟸   XM_038675090
- Peptide Label: isoform X6


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019499 Ensembl
NCBI Gene GRIN1 ENTREZGENE
UniProt Q5R1P0 ENTREZGENE
VGNC ID VGNC:41491 ENTREZGENE