UNC5B (unc-5 netrin receptor B) - Rat Genome Database

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Gene: UNC5B (unc-5 netrin receptor B) Canis lupus familiaris
Analyze
Symbol: UNC5B
Name: unc-5 netrin receptor B
RGD ID: 12267531
Description: ENCODES a protein that exhibits netrin receptor activity (ortholog); INVOLVED IN anterior/posterior axon guidance (ortholog); axon guidance (ortholog); positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Subarachnoid Hemorrhage (ortholog); FOUND IN membrane raft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: netrin receptor UNC5B; unc-5 homolog B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,003,131 - 22,084,107 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,003,131 - 22,081,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha422,139,026 - 22,219,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0422,280,582 - 22,358,557 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,280,284 - 22,357,950 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,178,248 - 22,258,859 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,383,898 - 22,464,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,736,647 - 22,817,352 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
UNC5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,003,131 - 22,084,107 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,003,131 - 22,081,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha422,139,026 - 22,219,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0422,280,582 - 22,358,557 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,280,284 - 22,357,950 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,178,248 - 22,258,859 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,383,898 - 22,464,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,736,647 - 22,817,352 (+)NCBIUU_Cfam_GSD_1.0
UNC5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381071,212,570 - 71,302,864 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1071,212,570 - 71,302,864 (+)EnsemblGRCh38hg38GRCh38
GRCh371072,972,327 - 73,062,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,642,353 - 72,729,722 (+)NCBINCBI36Build 36hg18NCBI36
Build 341072,642,354 - 72,729,714NCBI
Celera1066,254,788 - 66,343,547 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,966,129 - 67,056,670 (+)NCBIHuRef
CHM1_11073,254,992 - 73,345,299 (+)NCBICHM1_1
T2T-CHM13v2.01072,082,200 - 72,172,412 (+)NCBIT2T-CHM13v2.0
Unc5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,598,373 - 60,667,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,598,372 - 60,667,360 (-)EnsemblGRCm39 Ensembl
GRCm381060,762,594 - 60,831,581 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,762,593 - 60,831,581 (-)EnsemblGRCm38mm10GRCm38
MGSCv371060,225,343 - 60,294,329 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,157,952 - 60,226,938 (-)NCBIMGSCv36mm8
Celera1061,863,405 - 61,932,538 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1031.52NCBI
Unc5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,240,639 - 29,307,270 (-)NCBIGRCr8
mRatBN7.22028,697,726 - 28,764,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,697,726 - 28,764,537 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2029,713,216 - 29,779,955 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,099,533 - 29,166,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,842,007 - 29,908,740 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,339,680 - 30,406,593 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,339,673 - 30,406,295 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,148,315 - 32,215,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,095,243 - 28,162,204 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,109,042 - 28,176,004 (-)NCBI
Celera2030,138,282 - 30,201,182 (-)NCBICelera
Cytogenetic Map20q11NCBI
Unc5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,120,946 - 20,199,877 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,120,996 - 20,199,877 (-)NCBIChiLan1.0ChiLan1.0
UNC5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2883,362,648 - 83,453,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11083,367,973 - 83,458,343 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,682,415 - 67,772,760 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11070,207,998 - 70,298,038 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,207,998 - 70,298,038 (+)Ensemblpanpan1.1panPan2
Unc5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721358,980,118 - 59,055,010 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365217,470,663 - 7,547,793 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365217,472,788 - 7,547,408 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1474,120,050 - 74,205,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11474,120,055 - 74,208,055 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21480,011,267 - 80,098,887 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UNC5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,995,997 - 60,086,663 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604820,718,376 - 20,809,131 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247545,204,855 - 5,282,170 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247545,204,875 - 5,280,479 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UNC5B
1153 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000022760   ⟹   ENSCAFP00000021140
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl422,046,638 - 22,080,703 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000064110   ⟹   ENSCAFP00000047475
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl422,003,131 - 22,080,703 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000067386   ⟹   ENSCAFP00000058713
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl422,003,131 - 22,081,744 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845007984   ⟹   ENSCAFP00845006284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl422,280,284 - 22,357,950 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845008009   ⟹   ENSCAFP00845006302
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl422,280,284 - 22,357,950 (+)Ensembl
RefSeq Acc Id: XM_003638992   ⟹   XP_003639040
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1422,003,131 - 22,084,107 (+)NCBI
Dog10K_Boxer_Tasha422,139,026 - 22,219,691 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038473189   ⟹   XP_038329117
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1422,178,248 - 22,258,859 (+)NCBI
RefSeq Acc Id: XM_038473190   ⟹   XP_038329118
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1422,178,248 - 22,258,859 (+)NCBI
RefSeq Acc Id: XM_038534250   ⟹   XP_038390178
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0422,736,647 - 22,817,352 (+)NCBI
RefSeq Acc Id: XM_038534251   ⟹   XP_038390179
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0422,736,647 - 22,817,352 (+)NCBI
RefSeq Acc Id: XM_038598566   ⟹   XP_038454494
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0422,383,898 - 22,464,744 (+)NCBI
RefSeq Acc Id: XM_038662836   ⟹   XP_038518764
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0422,280,582 - 22,358,557 (+)NCBI
RefSeq Acc Id: XM_038662837   ⟹   XP_038518765
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0422,280,582 - 22,358,557 (+)NCBI
RefSeq Acc Id: XM_845335   ⟹   XP_850428
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1422,003,131 - 22,084,107 (+)NCBI
Dog10K_Boxer_Tasha422,139,026 - 22,219,691 (+)NCBI
Sequence:
RefSeq Acc Id: XP_850428   ⟸   XM_845335
- Peptide Label: isoform X2
- UniProtKB: A0A8C0N5Y9 (UniProtKB/TrEMBL),   A0A8I3MS99 (UniProtKB/TrEMBL),   A0A8C0LPB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003639040   ⟸   XM_003638992
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PT81 (UniProtKB/TrEMBL),   A0A8I3RTJ0 (UniProtKB/TrEMBL),   A0A8C0LPB0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000047475   ⟸   ENSCAFT00000064110
Ensembl Acc Id: ENSCAFP00000058713   ⟸   ENSCAFT00000067386
Ensembl Acc Id: ENSCAFP00000021140   ⟸   ENSCAFT00000022760
RefSeq Acc Id: XP_038329117   ⟸   XM_038473189
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038329118   ⟸   XM_038473190
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038454494   ⟸   XM_038598566
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038518764   ⟸   XM_038662836
- Peptide Label: isoform X2
- UniProtKB: A0A8C0N5Y9 (UniProtKB/TrEMBL),   A0A8I3MS99 (UniProtKB/TrEMBL),   A0A8C0LPB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038518765   ⟸   XM_038662837
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PT81 (UniProtKB/TrEMBL),   A0A8I3RTJ0 (UniProtKB/TrEMBL),   A0A8C0LPB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390178   ⟸   XM_038534250
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LPB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390179   ⟸   XM_038534251
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LPB0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845006302   ⟸   ENSCAFT00845008009
Ensembl Acc Id: ENSCAFP00845006284   ⟸   ENSCAFT00845007984
Protein Domains
Ig-like   ZU5

Promoters
RGD ID:13682912
Promoter ID:EPDNEW_C980
Type:multiple initiation site
Name:UNC5B_1
Description:unc-5 netrin receptor B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1422,003,504 - 22,003,564EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014319 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012897 UniProtKB/TrEMBL
  ENSCAFG00040000081 UniProtKB/TrEMBL
  ENSCAFG00845004449 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022760.5 UniProtKB/TrEMBL
  ENSCAFT00000064110.2 UniProtKB/TrEMBL
  ENSCAFT00030023823.1 UniProtKB/TrEMBL
  ENSCAFT00030023973.1 UniProtKB/TrEMBL
  ENSCAFT00030024102.1 UniProtKB/TrEMBL
  ENSCAFT00040000128.1 UniProtKB/TrEMBL
  ENSCAFT00040000174.1 UniProtKB/TrEMBL
  ENSCAFT00845007984 ENTREZGENE
  ENSCAFT00845007984.1 UniProtKB/TrEMBL
  ENSCAFT00845008009 ENTREZGENE
  ENSCAFT00845008009.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.20.100.10 UniProtKB/TrEMBL
  2.60.220.30 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  Death_UNC5B UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
  UNC5 UniProtKB/TrEMBL
  UPA UniProtKB/TrEMBL
  ZU5_dom UniProtKB/TrEMBL
NCBI Gene UNC5B ENTREZGENE
PANTHER NETRIN RECEPTOR UNC5B UniProtKB/TrEMBL
  PTHR12582 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
  UPA UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
PRINTS TSP1REPEAT UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A8C0LPB0 ENTREZGENE
  A0A8C0N5Y9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0N8J2_CANLF UniProtKB/TrEMBL
  A0A8C0N8U8_CANLF UniProtKB/TrEMBL
  A0A8C0PT81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MS99 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTJ0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48140 ENTREZGENE