ACSL5 (acyl-CoA synthetase long chain family member 5) - Rat Genome Database

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Gene: ACSL5 (acyl-CoA synthetase long chain family member 5) Canis lupus familiaris
Analyze
Symbol: ACSL5
Name: acyl-CoA synthetase long chain family member 5
RGD ID: 12266249
Description: ENCODES a protein that exhibits long-chain fatty acid-CoA ligase activity (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); fatty acid transport (ortholog); long-chain fatty-acyl-CoA biosynthetic process (ortholog); PARTICIPATES IN fatty acid beta degradation pathway; ASSOCIATED WITH Experimental Arthritis (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acyl-CoA synthetase long-chain family member 5; long-chain-fatty-acid--CoA ligase 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12823,437,838 - 23,478,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2823,440,387 - 23,478,762 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2823,589,635 - 23,630,543 (+)NCBI
ROS_Cfam_1.02823,970,117 - 24,011,237 (+)NCBI
ROS_Cfam_1.0 Ensembl2823,971,931 - 24,069,062 (+)Ensembl
UMICH_Zoey_3.12823,527,397 - 23,568,302 (+)NCBI
UNSW_CanFamBas_1.02823,538,540 - 23,579,462 (+)NCBI
UU_Cfam_GSD_1.02823,737,237 - 23,775,914 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:33106515  


Genomics

Comparative Map Data
ACSL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12823,437,838 - 23,478,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2823,440,387 - 23,478,762 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2823,589,635 - 23,630,543 (+)NCBI
ROS_Cfam_1.02823,970,117 - 24,011,237 (+)NCBI
ROS_Cfam_1.0 Ensembl2823,971,931 - 24,069,062 (+)Ensembl
UMICH_Zoey_3.12823,527,397 - 23,568,302 (+)NCBI
UNSW_CanFamBas_1.02823,538,540 - 23,579,462 (+)NCBI
UU_Cfam_GSD_1.02823,737,237 - 23,775,914 (+)NCBI
ACSL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810112,374,116 - 112,428,376 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10112,374,116 - 112,428,379 (+)EnsemblGRCh38hg38GRCh38
GRCh3710114,133,874 - 114,188,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,123,906 - 114,178,128 (+)NCBINCBI36hg18NCBI36
Celera10107,861,444 - 107,915,662 (+)NCBI
Cytogenetic Map10q25.2NCBI
HuRef10107,761,898 - 107,815,784 (+)NCBIHuRef
CHM1_110114,415,634 - 114,469,870 (+)NCBICHM1_1
T2T-CHM13v2.010113,265,142 - 113,319,056 (+)NCBI
Acsl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391955,240,298 - 55,285,060 (+)NCBIGRCm39mm39
GRCm39 Ensembl1955,240,370 - 55,286,152 (+)Ensembl
GRCm381955,251,861 - 55,296,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1955,251,938 - 55,297,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv371955,327,859 - 55,371,118 (+)NCBIGRCm37mm9NCBIm37
MGSCv361955,306,619 - 55,349,878 (+)NCBImm8
Celera1957,444,332 - 57,487,767 (+)NCBICelera
Cytogenetic Map19D2NCBI
Acsl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21254,289,513 - 254,336,608 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1254,292,521 - 254,336,607 (+)Ensembl
Rnor_6.01276,240,703 - 276,290,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,240,703 - 276,290,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01283,637,899 - 283,685,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41261,554,383 - 261,599,373 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11261,765,427 - 261,810,418 (+)NCBI
Celera1249,999,118 - 250,043,312 (+)NCBICelera
Cytogenetic Map1q55NCBI
Acsl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543117,477,086 - 17,524,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543117,477,113 - 17,524,539 (+)NCBIChiLan1.0ChiLan1.0
ACSL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110112,405,069 - 112,457,892 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10112,407,161 - 112,457,892 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010108,965,559 - 109,019,240 (+)NCBIMhudiblu_PPA_v0panPan3
Acsl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721322,569,123 - 22,610,342 (-)NCBI
SpeTri2.0NW_0049364862,952,379 - 2,992,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14122,777,130 - 122,828,052 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114122,777,135 - 122,828,054 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214133,689,844 - 133,751,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19105,259,546 - 105,311,500 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl9105,257,429 - 105,311,690 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604866,462,251 - 66,514,618 (+)NCBIVero_WHO_p1.0
Acsl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473734,038,518 - 34,091,661 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473734,038,610 - 34,091,579 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 15 6 6 6 5 4 8 10 6
Low 1 5 7 1 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005637729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005637730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005637731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022411794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038440559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038440560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038440561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038440562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038515185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038515186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038515187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038515188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038578793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038642971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038642972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038642973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038642974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000012348   ⟹   ENSCAFP00000011446
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2823,440,387 - 23,478,762 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000017419   ⟹   ENSCAFP00000016128
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2823,440,387 - 23,477,765 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845052633   ⟹   ENSCAFP00845041306
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2823,971,931 - 24,069,062 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845052694   ⟹   ENSCAFP00845041361
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2823,972,623 - 24,011,205 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845052714   ⟹   ENSCAFP00845041377
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2823,972,656 - 24,010,239 (+)Ensembl
RefSeq Acc Id: XM_005637729   ⟹   XP_005637786
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12823,453,666 - 23,478,763 (+)NCBI
Dog10K_Boxer_Tasha2823,605,440 - 23,630,543 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005637730   ⟹   XP_005637787
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12823,437,838 - 23,478,763 (+)NCBI
Dog10K_Boxer_Tasha2823,589,635 - 23,630,543 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005637731   ⟹   XP_005637788
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12823,440,341 - 23,478,763 (+)NCBI
Dog10K_Boxer_Tasha2823,592,110 - 23,630,543 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022411794   ⟹   XP_022267502
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12823,452,397 - 23,478,763 (+)NCBI
Dog10K_Boxer_Tasha2823,604,176 - 23,630,543 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038440559   ⟹   XP_038296487
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02823,972,591 - 24,011,237 (+)NCBI
RefSeq Acc Id: XM_038440560   ⟹   XP_038296488
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02823,970,117 - 24,011,237 (+)NCBI
RefSeq Acc Id: XM_038440561   ⟹   XP_038296489
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02823,985,918 - 24,011,237 (+)NCBI
RefSeq Acc Id: XM_038440562   ⟹   XP_038296490
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02823,984,654 - 24,011,237 (+)NCBI
RefSeq Acc Id: XM_038515185   ⟹   XP_038371113
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12823,529,871 - 23,568,302 (+)NCBI
RefSeq Acc Id: XM_038515186   ⟹   XP_038371114
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12823,527,397 - 23,568,302 (+)NCBI
RefSeq Acc Id: XM_038515187   ⟹   XP_038371115
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12823,543,207 - 23,568,302 (+)NCBI
RefSeq Acc Id: XM_038515188   ⟹   XP_038371116
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12823,541,943 - 23,568,302 (+)NCBI
RefSeq Acc Id: XM_038578793   ⟹   XP_038434721
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02823,737,237 - 23,775,914 (+)NCBI
RefSeq Acc Id: XM_038642971   ⟹   XP_038498899
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02823,541,015 - 23,579,462 (+)NCBI
RefSeq Acc Id: XM_038642972   ⟹   XP_038498900
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02823,538,540 - 23,579,462 (+)NCBI
RefSeq Acc Id: XM_038642973   ⟹   XP_038498901
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02823,554,357 - 23,579,462 (+)NCBI
RefSeq Acc Id: XM_038642974   ⟹   XP_038498902
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02823,553,093 - 23,579,462 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005637787   ⟸   XM_005637730
- UniProtKB: F1Q0U3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005637788   ⟸   XM_005637731
- UniProtKB: F1Q0U3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005637786   ⟸   XM_005637729
- UniProtKB: F1Q0U3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022267502   ⟸   XM_022411794
- Sequence:
RefSeq Acc Id: ENSCAFP00000016128   ⟸   ENSCAFT00000017419
RefSeq Acc Id: ENSCAFP00000011446   ⟸   ENSCAFT00000012348
RefSeq Acc Id: XP_038371114   ⟸   XM_038515186
RefSeq Acc Id: XP_038371113   ⟸   XM_038515185
RefSeq Acc Id: XP_038371116   ⟸   XM_038515188
RefSeq Acc Id: XP_038371115   ⟸   XM_038515187
RefSeq Acc Id: XP_038498900   ⟸   XM_038642972
RefSeq Acc Id: XP_038498899   ⟸   XM_038642971
RefSeq Acc Id: XP_038498902   ⟸   XM_038642974
RefSeq Acc Id: XP_038498901   ⟸   XM_038642973
RefSeq Acc Id: XP_038296488   ⟸   XM_038440560
RefSeq Acc Id: XP_038296487   ⟸   XM_038440559
RefSeq Acc Id: XP_038296490   ⟸   XM_038440562
RefSeq Acc Id: XP_038296489   ⟸   XM_038440561
RefSeq Acc Id: XP_038434721   ⟸   XM_038578793
RefSeq Acc Id: ENSCAFP00845041306   ⟸   ENSCAFT00845052633
RefSeq Acc Id: ENSCAFP00845041361   ⟸   ENSCAFT00845052694
RefSeq Acc Id: ENSCAFP00845041377   ⟸   ENSCAFT00845052714
Protein Domains
AMP-binding   AMP-binding_C

Promoters
RGD ID:13688339
Promoter ID:EPDNEW_C6406
Type:multiple initiation site
Name:ACSL5_1
Description:acyl-CoA synthetase long chain family member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12823,453,683 - 23,453,743EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
28 23461471 23461472 C A snv German Shepherd/Mixed breed (DS042), German Shepherd/Mixed breed (DS041)
28 23465423 23465424 T C snv Malinois (MA008), Malinois (MA152), Shetland Sheepdog (SS004), Eurasier (EU035), Doberman Pinscher (DO263), Weimaraner (WE006)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010928 Ensembl
  ENSCAFG00030018834 UniProtKB/TrEMBL
  ENSCAFG00040020540 UniProtKB/TrEMBL
  ENSCAFG00845029720 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030030247.1 UniProtKB/TrEMBL
  ENSCAFP00030030349.1 UniProtKB/TrEMBL
  ENSCAFP00040033122 UniProtKB/TrEMBL
  ENSCAFP00040033138 UniProtKB/TrEMBL
  ENSCAFP00845041306.1 UniProtKB/TrEMBL
  ENSCAFP00845041361 ENTREZGENE
  ENSCAFP00845041361.1 UniProtKB/TrEMBL
  ENSCAFP00845041377.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030034684.1 UniProtKB/TrEMBL
  ENSCAFT00030034803.1 UniProtKB/TrEMBL
  ENSCAFT00040037998 UniProtKB/TrEMBL
  ENSCAFT00040038015 UniProtKB/TrEMBL
  ENSCAFT00845052633.1 UniProtKB/TrEMBL
  ENSCAFT00845052694 ENTREZGENE
  ENSCAFT00845052694.1 UniProtKB/TrEMBL
  ENSCAFT00845052714.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12780 UniProtKB/TrEMBL
InterPro AMP-bd_C UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/TrEMBL
  ANL_N_sf UniProtKB/TrEMBL
  LC-FACS_euk UniProtKB/TrEMBL
NCBI Gene ACSL5 ENTREZGENE
Pfam AMP-binding UniProtKB/TrEMBL
  AMP-binding_C UniProtKB/TrEMBL
PROSITE AMP_BINDING UniProtKB/TrEMBL
UniProt A0A8C0NSC4_CANLF UniProtKB/TrEMBL
  A0A8C0TA81_CANLF UniProtKB/TrEMBL
  A0A8I3Q1U2_CANLF UniProtKB/TrEMBL
  A0A8I3S7A1_CANLF UniProtKB/TrEMBL
  A0A8I3SCF4_CANLF UniProtKB/TrEMBL
  F1Q0U3 ENTREZGENE
VGNC ID VGNC:37535 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 ACSL5  acyl-CoA synthetase long chain family member 5    acyl-CoA synthetase long-chain family member 5  Symbol and/or name change 5135510 APPROVED