FBXO3 (F-box protein 3) - Rat Genome Database

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Gene: FBXO3 (F-box protein 3) Canis lupus familiaris
Analyze
Symbol: FBXO3
Name: F-box protein 3
RGD ID: 12266234
Description: ENCODES a protein that exhibits ubiquitin ligase-substrate adaptor activity (inferred); INVOLVED IN response to lipopolysaccharide (inferred); SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-box only protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11833,944,441 - 33,974,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1833,944,451 - 33,973,968 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1833,550,035 - 33,580,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01834,555,537 - 34,586,084 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1834,555,537 - 34,594,140 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11834,114,297 - 34,144,819 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01833,707,460 - 33,737,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01834,343,094 - 34,373,628 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
FBXO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11833,944,441 - 33,974,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1833,944,451 - 33,973,968 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1833,550,035 - 33,580,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01834,555,537 - 34,586,084 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1834,555,537 - 34,594,140 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11834,114,297 - 34,144,819 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01833,707,460 - 33,737,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01834,343,094 - 34,373,628 (+)NCBIUU_Cfam_GSD_1.0
FBXO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381133,740,944 - 33,774,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1133,740,939 - 33,774,543 (-)EnsemblGRCh38hg38GRCh38
GRCh371133,762,490 - 33,796,066 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361133,719,066 - 33,752,647 (-)NCBINCBI36Build 36hg18NCBI36
Build 341133,724,868 - 33,752,647NCBI
Celera1133,909,992 - 33,943,582 (-)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1133,458,657 - 33,492,237 (-)NCBIHuRef
CHM1_11133,762,004 - 33,795,579 (-)NCBICHM1_1
T2T-CHM13v2.01133,877,954 - 33,911,529 (-)NCBIT2T-CHM13v2.0
Fbxo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392103,858,144 - 103,893,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2103,858,066 - 103,893,585 (+)EnsemblGRCm39 Ensembl
GRCm382104,027,799 - 104,063,237 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2104,027,721 - 104,063,240 (+)EnsemblGRCm38mm10GRCm38
MGSCv372103,867,956 - 103,903,394 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362103,828,638 - 103,864,076 (+)NCBIMGSCv36mm8
Celera2105,265,922 - 105,300,910 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map254.49NCBI
Fbxo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83110,872,185 - 110,904,479 (+)NCBIGRCr8
mRatBN7.2390,417,262 - 90,449,557 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl390,417,297 - 90,449,557 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx393,910,311 - 93,942,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03102,509,388 - 102,541,746 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03100,339,746 - 100,372,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0393,968,827 - 94,000,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl393,968,855 - 94,000,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03100,608,746 - 100,640,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4389,446,724 - 89,479,650 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera389,478,591 - 89,510,807 (+)NCBICelera
Cytogenetic Map3q32NCBI
Fbxo3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542212,461,858 - 12,494,553 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542212,462,329 - 12,492,030 (+)NCBIChiLan1.0ChiLan1.0
FBXO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2935,960,609 - 35,994,171 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11135,965,323 - 35,998,916 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01133,713,147 - 33,746,730 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,594,854 - 33,628,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,594,854 - 33,628,399 (-)Ensemblpanpan1.1panPan2
Fbxo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494731,075,996 - 31,108,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365334,200,757 - 4,234,145 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365334,200,791 - 4,232,929 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl227,146,444 - 27,184,181 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1227,146,407 - 27,183,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2229,513,804 - 29,539,556 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1131,509,950 - 31,543,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl131,509,956 - 31,543,611 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038128,605,747 - 128,639,998 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476713,379,895 - 13,410,210 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476713,382,187 - 13,410,143 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FBXO3
226 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 4 6 6 6 12 8 10 6
Low 2
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000011480   ⟹   ENSCAFP00000010637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1833,944,451 - 33,973,968 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044104   ⟹   ENSCAFP00845034558
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1834,555,537 - 34,583,188 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044220   ⟹   ENSCAFP00845034654
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1834,555,566 - 34,594,140 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044341   ⟹   ENSCAFP00845034745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1834,555,587 - 34,586,068 (+)Ensembl
RefSeq Acc Id: XM_038424138   ⟹   XP_038280066
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01834,555,537 - 34,586,084 (+)NCBI
RefSeq Acc Id: XM_038500485   ⟹   XP_038356413
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11834,114,297 - 34,144,819 (+)NCBI
RefSeq Acc Id: XM_038563057   ⟹   XP_038418985
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01834,343,094 - 34,373,628 (+)NCBI
RefSeq Acc Id: XM_038627180   ⟹   XP_038483108
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01833,707,460 - 33,737,980 (+)NCBI
RefSeq Acc Id: XM_844163   ⟹   XP_849256
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11833,944,441 - 33,974,944 (+)NCBI
Dog10K_Boxer_Tasha1833,550,035 - 33,580,545 (+)NCBI
Sequence:
RefSeq Acc Id: XP_849256   ⟸   XM_844163
- UniProtKB: A0A8C0PGM0 (UniProtKB/TrEMBL),   A0A8I3PT61 (UniProtKB/TrEMBL),   A0A8I3PSW7 (UniProtKB/TrEMBL),   A0A8P0PJZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010637   ⟸   ENSCAFT00000011480
RefSeq Acc Id: XP_038356413   ⟸   XM_038500485
RefSeq Acc Id: XP_038483108   ⟸   XM_038627180
RefSeq Acc Id: XP_038280066   ⟸   XM_038424138
- UniProtKB: A0A8C0PGM0 (UniProtKB/TrEMBL),   A0A8I3PT61 (UniProtKB/TrEMBL),   A0A8I3PSW7 (UniProtKB/TrEMBL),   A0A8P0PJZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418985   ⟸   XM_038563057
- UniProtKB: A0A8C0PGM0 (UniProtKB/TrEMBL),   A0A8I3PSW7 (UniProtKB/TrEMBL),   A0A8I3PT61 (UniProtKB/TrEMBL),   A0A8P0PJZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845034745   ⟸   ENSCAFT00845044341
RefSeq Acc Id: ENSCAFP00845034558   ⟸   ENSCAFT00845044104
RefSeq Acc Id: ENSCAFP00845034654   ⟸   ENSCAFT00845044220
Protein Domains
ApaG   F-box

Promoters
RGD ID:13686485
Promoter ID:EPDNEW_C4553
Type:multiple initiation site
Name:FBXO3_1
Description:F-box protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11833,944,475 - 33,944,535EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007148 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022641 UniProtKB/TrEMBL
  ENSCAFG00040018115 UniProtKB/TrEMBL
  ENSCAFG00845024924 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011480.5 UniProtKB/TrEMBL
  ENSCAFT00000095167.1 UniProtKB/TrEMBL
  ENSCAFT00030041670.1 UniProtKB/TrEMBL
  ENSCAFT00040033540.1 UniProtKB/TrEMBL
  ENSCAFT00845044104.1 UniProtKB/TrEMBL
  ENSCAFT00845044220 ENTREZGENE
  ENSCAFT00845044220.1 UniProtKB/TrEMBL
  ENSCAFT00845044341.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.60.40.1470 UniProtKB/TrEMBL
  3.40.1580.10 UniProtKB/TrEMBL
InterPro ApaG_domain UniProtKB/TrEMBL
  ApaG_sf UniProtKB/TrEMBL
  F-box-like_dom_sf UniProtKB/TrEMBL
  F-box_dom UniProtKB/TrEMBL
  Knr4/Smi1-like_dom UniProtKB/TrEMBL
  Knr4/Smi1-like_sf UniProtKB/TrEMBL
KEGG Report cfa:475944 UniProtKB/TrEMBL
NCBI Gene FBXO3 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 3 UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 3 UniProtKB/TrEMBL
Pfam DUF525 UniProtKB/TrEMBL
  F-box-like UniProtKB/TrEMBL
  SMI1_KNR4 UniProtKB/TrEMBL
PROSITE APAG UniProtKB/TrEMBL
  FBOX UniProtKB/TrEMBL
SMART FBOX UniProtKB/TrEMBL
  SMI1_KNR4 UniProtKB/TrEMBL
Superfamily-SCOP SSF110069 UniProtKB/TrEMBL
  SSF160631 UniProtKB/TrEMBL
  SSF81383 UniProtKB/TrEMBL
UniProt A0A8C0PGM0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PSW7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PT61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PTK8_CANLF UniProtKB/TrEMBL
  A0A8P0PJZ5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40771 ENTREZGENE