DNA2 (DNA replication helicase/nuclease 2) - Rat Genome Database

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Gene: DNA2 (DNA replication helicase/nuclease 2) Canis lupus familiaris
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Symbol: DNA2
Name: DNA replication helicase/nuclease 2
RGD ID: 12265949
Description: ENCODES a protein that exhibits 5'-3' DNA helicase activity (ortholog); 5'-flap endonuclease activity (ortholog); DNA binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA double-strand break processing (ortholog); DNA replication (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 (ortholog); congenital myopathy (ortholog); genetic disease (ortholog); FOUND IN chromosome, telomeric region (ortholog); gamma DNA polymerase complex (ortholog); mitochondrial nucleoid (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA2L
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,626,001 - 19,683,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,626,977 - 19,684,660 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,758,312 - 19,814,534 (-)NCBI
ROS_Cfam_1.0419,896,502 - 19,954,684 (-)NCBI
UMICH_Zoey_3.1419,798,388 - 19,856,607 (-)NCBI
UNSW_CanFamBas_1.0420,000,469 - 20,058,335 (-)NCBI
UU_Cfam_GSD_1.0420,343,723 - 20,401,576 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
DNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,626,001 - 19,683,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,626,977 - 19,684,660 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,758,312 - 19,814,534 (-)NCBI
ROS_Cfam_1.0419,896,502 - 19,954,684 (-)NCBI
UMICH_Zoey_3.1419,798,388 - 19,856,607 (-)NCBI
UNSW_CanFamBas_1.0420,000,469 - 20,058,335 (-)NCBI
UU_Cfam_GSD_1.0420,343,723 - 20,401,576 (-)NCBI
DNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1068,414,064 - 68,472,121 (-)EnsemblGRCh38hg38GRCh38
GRCh381068,414,064 - 68,472,521 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371070,173,821 - 70,231,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,843,827 - 69,901,885 (-)NCBINCBI36hg18NCBI36
Build 341069,843,827 - 69,901,678NCBI
Celera1063,449,181 - 63,507,264 (-)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1064,173,263 - 64,231,457 (-)NCBIHuRef
CHM1_11070,455,594 - 70,514,126 (-)NCBICHM1_1
Dna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,782,762 - 62,809,967 (+)NCBIGRCm39mm39
GRCm39 Ensembl1062,782,805 - 62,809,964 (+)Ensembl
GRCm381062,946,983 - 62,974,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,947,026 - 62,974,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv371062,409,777 - 62,436,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv361062,342,410 - 62,369,534 (+)NCBImm8
Celera1064,048,162 - 64,075,318 (+)NCBICelera
Cytogenetic Map10B4NCBI
Dna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22025,661,652 - 25,690,598 (-)NCBImRatBN7.2
Rnor_5.02029,093,620 - 29,123,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,288,326 - 25,316,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12025,302,172 - 25,363,960 (+)NCBI
Celera2026,956,734 - 26,986,153 (-)NCBICelera
Cytogenetic Map20p11NCBI
Dna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,661,727 - 20,702,754 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,664,412 - 20,705,070 (-)NCBIChiLan1.0ChiLan1.0
DNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11067,207,261 - 67,264,257 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1067,207,261 - 67,264,257 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01064,898,024 - 64,956,541 (-)NCBIMhudiblu_PPA_v0panPan3
Dna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,351,058 - 61,392,148 (+)NCBI
SpeTri2.0NW_0049365219,843,867 - 9,884,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,549,815 - 71,651,089 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,550,405 - 71,607,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,609,353 - 77,643,988 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,926,221 - 62,985,843 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl962,926,674 - 62,985,842 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604823,687,256 - 23,749,223 (+)NCBIVero_WHO_p1.0
Dna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247542,746,912 - 2,791,560 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 4 8 6 6 10 8 4
Below cutoff 1 5 14 6 6 4 2 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000021752   ⟹   ENSCAFP00000020204
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl419,626,977 - 19,684,660 (-)Ensembl
RefSeq Acc Id: XM_038473085   ⟹   XP_038329013
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1419,798,388 - 19,856,607 (-)NCBI
RefSeq Acc Id: XM_038489995   ⟹   XP_038345923
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha419,758,312 - 19,814,534 (-)NCBI
RefSeq Acc Id: XM_038534133   ⟹   XP_038390061
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0420,343,723 - 20,401,576 (-)NCBI
RefSeq Acc Id: XM_038598451   ⟹   XP_038454379
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0420,000,469 - 20,058,335 (-)NCBI
RefSeq Acc Id: XM_038662754   ⟹   XP_038518682
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0419,896,502 - 19,954,684 (-)NCBI
Reference Sequences
RefSeq Acc Id: ENSCAFP00000020204   ⟸   ENSCAFT00000021752
RefSeq Acc Id: XP_038329013   ⟸   XM_038473085
RefSeq Acc Id: XP_038454379   ⟸   XM_038598451
RefSeq Acc Id: XP_038518682   ⟸   XM_038662754
RefSeq Acc Id: XP_038345923   ⟸   XM_038489995
RefSeq Acc Id: XP_038390061   ⟸   XM_038534133


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013710 Ensembl
NCBI Gene DNA2 ENTREZGENE
VGNC ID VGNC:40008 ENTREZGENE