KLHL6 (kelch like family member 6) - Rat Genome Database

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Gene: KLHL6 (kelch like family member 6) Canis lupus familiaris
Analyze
Symbol: KLHL6
Name: kelch like family member 6
RGD ID: 12265855
Description: INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH 3-Methylcrotonyl-CoA carboxylase 1 deficiency (ortholog); congenital disorder of glycosylation Id (ortholog); Currarino syndrome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 6; kelch-like protein 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,443,282 - 16,556,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3416,446,944 - 16,504,549 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,531,581 - 20,645,243 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,351,275 - 16,464,989 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,351,275 - 16,472,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13416,390,376 - 16,503,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,376,664 - 16,438,114 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03416,614,814 - 16,728,495 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,443,282 - 16,556,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3416,446,944 - 16,504,549 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,531,581 - 20,645,243 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,351,275 - 16,464,989 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,351,275 - 16,472,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13416,390,376 - 16,503,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,376,664 - 16,438,114 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03416,614,814 - 16,728,495 (-)NCBIUU_Cfam_GSD_1.0
KLHL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383183,487,551 - 183,555,706 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3183,487,551 - 183,555,706 (-)EnsemblGRCh38hg38GRCh38
GRCh373183,205,339 - 183,273,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363184,688,013 - 184,756,193 (-)NCBINCBI36Build 36hg18NCBI36
Build 343184,688,040 - 184,756,110NCBI
Celera3181,641,698 - 181,709,843 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3180,611,770 - 180,679,998 (-)NCBIHuRef
CHM1_13183,168,972 - 183,237,150 (-)NCBICHM1_1
T2T-CHM13v2.03186,295,709 - 186,363,954 (-)NCBIT2T-CHM13v2.0
Klhl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391619,765,242 - 19,801,766 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1619,765,246 - 19,801,787 (-)EnsemblGRCm39 Ensembl
GRCm381619,946,492 - 19,983,049 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1619,946,496 - 19,983,037 (-)EnsemblGRCm38mm10GRCm38
MGSCv371619,946,586 - 19,983,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361619,860,060 - 19,896,520 (-)NCBIMGSCv36mm8
Celera1620,509,929 - 20,546,858 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.32NCBI
Klhl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,475,262 - 94,514,653 (+)NCBIGRCr8
mRatBN7.21180,970,917 - 81,010,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,970,917 - 81,009,677 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,698,651 - 89,745,379 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,352,005 - 82,398,737 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,413,148 - 81,459,874 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,745,958 - 84,785,315 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,745,904 - 84,785,893 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,808,385 - 87,847,742 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41183,221,776 - 83,260,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11183,279,726 - 83,318,448 (+)NCBI
Celera1179,806,183 - 79,844,910 (+)NCBICelera
Cytogenetic Map11q23NCBI
Klhl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542023,813,482 - 23,877,886 (+)NCBIChiLan1.0ChiLan1.0
KLHL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22181,362,659 - 181,427,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13181,367,374 - 181,432,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03180,523,141 - 180,591,218 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13188,692,193 - 188,760,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3188,692,200 - 188,760,926 (-)Ensemblpanpan1.1panPan2
Klhl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602120,134,597 - 120,194,353 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365786,226,495 - 6,284,293 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365786,226,533 - 6,284,343 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113121,426,618 - 121,487,260 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213130,829,174 - 130,850,400 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,844,728 - 5,912,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,845,721 - 5,913,734 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606314,630,818 - 14,705,887 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473072,916,601 - 72,972,204 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLHL6
1201 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 3 12 5 6 5 6 2 3 8 6 6
Below cutoff 2 10 1 1 4 9 4

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022414172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038462804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_545220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000018788   ⟹   ENSCAFP00000017408
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3416,446,944 - 16,504,549 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845039858   ⟹   ENSCAFP00845031216
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3416,351,275 - 16,472,437 (-)Ensembl
RefSeq Acc Id: XM_022414172   ⟹   XP_022269880
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13416,443,282 - 16,556,991 (-)NCBI
Dog10K_Boxer_Tasha3420,531,581 - 20,645,243 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022414173   ⟹   XP_022269881
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13416,448,943 - 16,504,809 (-)NCBI
Dog10K_Boxer_Tasha3420,537,244 - 20,592,993 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038445676   ⟹   XP_038301604
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03416,351,275 - 16,412,669 (-)NCBI
RefSeq Acc Id: XM_038445677   ⟹   XP_038301605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03416,351,275 - 16,464,989 (-)NCBI
RefSeq Acc Id: XM_038445678   ⟹   XP_038301606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03416,351,275 - 16,425,560 (-)NCBI
RefSeq Acc Id: XM_038445679   ⟹   XP_038301607
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03416,356,938 - 16,412,694 (-)NCBI
RefSeq Acc Id: XM_038462804   ⟹   XP_038318732
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3420,531,581 - 20,605,836 (-)NCBI
RefSeq Acc Id: XM_038519863   ⟹   XP_038375791
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13416,390,376 - 16,451,757 (-)NCBI
RefSeq Acc Id: XM_038519864   ⟹   XP_038375792
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13416,390,376 - 16,503,817 (-)NCBI
RefSeq Acc Id: XM_038519865   ⟹   XP_038375793
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13416,390,376 - 16,464,633 (-)NCBI
RefSeq Acc Id: XM_038519866   ⟹   XP_038375794
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13416,396,038 - 16,451,782 (-)NCBI
RefSeq Acc Id: XM_038583502   ⟹   XP_038439430
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03416,614,814 - 16,676,204 (-)NCBI
RefSeq Acc Id: XM_038583503   ⟹   XP_038439431
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03416,614,814 - 16,728,495 (-)NCBI
RefSeq Acc Id: XM_038583504   ⟹   XP_038439432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03416,614,814 - 16,689,091 (-)NCBI
RefSeq Acc Id: XM_038583505   ⟹   XP_038439433
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03416,620,477 - 16,676,229 (-)NCBI
RefSeq Acc Id: XM_038647911   ⟹   XP_038503839
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03416,376,664 - 16,438,089 (-)NCBI
RefSeq Acc Id: XM_038647912   ⟹   XP_038503840
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03416,382,327 - 16,438,114 (-)NCBI
RefSeq Acc Id: XM_545220   ⟹   XP_545220
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13416,443,282 - 16,504,773 (-)NCBI
Dog10K_Boxer_Tasha3420,531,581 - 20,592,968 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_545220   ⟸   XM_545220
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JJS1 (UniProtKB/TrEMBL),   A0A8C0TIA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022269880   ⟸   XM_022414172
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TJD4 (UniProtKB/TrEMBL),   A0A8I3PFF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022269881   ⟸   XM_022414173
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000017408   ⟸   ENSCAFT00000018788
RefSeq Acc Id: XP_038375792   ⟸   XM_038519864
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038375793   ⟸   XM_038519865
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038375791   ⟸   XM_038519863
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038375794   ⟸   XM_038519866
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038503839   ⟸   XM_038647911
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038503840   ⟸   XM_038647912
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038301605   ⟸   XM_038445677
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TJD4 (UniProtKB/TrEMBL),   A0A8I3PFF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038301606   ⟸   XM_038445678
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TJD4 (UniProtKB/TrEMBL),   A0A8I3PFF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038301604   ⟸   XM_038445676
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JJS1 (UniProtKB/TrEMBL),   A0A8C0TIA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038301607   ⟸   XM_038445679
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038318732   ⟸   XM_038462804
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TJD4 (UniProtKB/TrEMBL),   A0A8I3PFF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439431   ⟸   XM_038583503
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TJD4 (UniProtKB/TrEMBL),   A0A8I3PFF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439432   ⟸   XM_038583504
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TJD4 (UniProtKB/TrEMBL),   A0A8I3PFF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439430   ⟸   XM_038583502
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JJS1 (UniProtKB/TrEMBL),   A0A8C0TIA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439433   ⟸   XM_038583505
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCAFP00845031216   ⟸   ENSCAFT00845039858
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011828 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013849 UniProtKB/TrEMBL
  ENSCAFG00040022516 UniProtKB/TrEMBL
  ENSCAFG00845022563 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018788.5 UniProtKB/TrEMBL
  ENSCAFT00030025738.1 UniProtKB/TrEMBL
  ENSCAFT00030025825.1 UniProtKB/TrEMBL
  ENSCAFT00040041816.1 UniProtKB/TrEMBL
  ENSCAFT00040041860.1 UniProtKB/TrEMBL
  ENSCAFT00845039858 ENTREZGENE
  ENSCAFT00845039858.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  BTB_POZ_KLHL6 UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene KLHL6 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  PTHR24412:SF428 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A8C0JJS1 ENTREZGENE
  A0A8C0TIA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TJD4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PFF2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42475 ENTREZGENE