CA8 (carbonic anhydrase 8) - Rat Genome Database

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Gene: CA8 (carbonic anhydrase 8) Canis lupus familiaris
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Symbol: CA8
Name: carbonic anhydrase 8
RGD ID: 12263069
Description: ENCODES a protein that exhibits carbonate dehydratase activity (inferred); zinc ion binding (inferred); INVOLVED IN phosphatidylinositol-mediated signaling (ortholog); ASSOCIATED WITH Cerebellar Ataxia, Mental Retardation, and Dysequilibrium Syndrome 3 (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: carbonic anhydrase-related protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12910,678,122 - 10,763,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2910,679,038 - 10,764,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2910,989,287 - 11,075,445 (-)NCBI
ROS_Cfam_1.02910,763,585 - 10,849,785 (-)NCBI
UMICH_Zoey_3.12910,765,703 - 10,851,540 (-)NCBI
UNSW_CanFamBas_1.02910,899,217 - 10,985,514 (-)NCBI
UU_Cfam_GSD_1.02911,167,585 - 11,253,944 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

Genomics

Comparative Map Data
CA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12910,678,122 - 10,763,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2910,679,038 - 10,764,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2910,989,287 - 11,075,445 (-)NCBI
ROS_Cfam_1.02910,763,585 - 10,849,785 (-)NCBI
UMICH_Zoey_3.12910,765,703 - 10,851,540 (-)NCBI
UNSW_CanFamBas_1.02910,899,217 - 10,985,514 (-)NCBI
UU_Cfam_GSD_1.02911,167,585 - 11,253,944 (-)NCBI
CA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl860,185,412 - 60,281,400 (-)EnsemblGRCh38hg38GRCh38
GRCh38860,185,412 - 60,281,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37861,097,971 - 61,193,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36861,263,977 - 61,356,508 (-)NCBINCBI36hg18NCBI36
Build 34861,263,976 - 61,356,508NCBI
Celera857,092,480 - 57,182,989 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef856,589,359 - 56,681,767 (-)NCBIHuRef
CHM1_1861,150,010 - 61,246,037 (-)NCBICHM1_1
Car8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3948,141,493 - 8,239,226 (-)NCBIGRCm39mm39
GRCm39 Ensembl48,143,362 - 8,239,041 (-)Ensembl
GRCm3848,141,493 - 8,239,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl48,143,362 - 8,239,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv3748,068,640 - 8,166,188 (-)NCBIGRCm37mm9NCBIm37
MGSCv3647,613,848 - 7,709,581 (-)NCBImm8
MGSCv3648,068,640 - 8,166,188 (-)NCBImm8
Celera48,024,484 - 8,115,866 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map43.53NCBI
Ca8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2521,302,940 - 21,402,395 (-)NCBI
Rnor_6.0 Ensembl521,249,020 - 21,345,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0521,249,018 - 21,345,810 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0526,010,374 - 26,106,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4521,951,255 - 22,049,427 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1521,951,256 - 22,049,427 (-)NCBI
Celera520,578,323 - 20,675,389 (-)NCBICelera
Cytogenetic Map5q13NCBI
Ca8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544418,413,958 - 18,512,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544418,414,006 - 18,510,800 (+)NCBIChiLan1.0ChiLan1.0
CA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1858,273,696 - 58,367,615 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl858,273,696 - 58,367,615 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0856,606,454 - 56,702,357 (-)NCBIMhudiblu_PPA_v0panPan3
Ca8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530361,800,602 - 61,889,623 (-)NCBI
SpeTri2.0NW_00493649612,895,858 - 12,984,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl473,047,847 - 73,141,991 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1473,047,867 - 73,172,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2479,510,120 - 79,573,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1856,111,149 - 56,203,797 (-)NCBI
ChlSab1.1 Ensembl856,131,599 - 56,203,336 (-)Ensembl
Ca8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474431,659,318 - 31,777,409 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 11 6 6 4 5
Low 5 11 6 6 5 8 5
Below cutoff 1 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011451   ⟹   ENSCAFP00000010611
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2910,698,640 - 10,764,193 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000075062   ⟹   ENSCAFP00000063044
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2910,679,038 - 10,764,193 (-)Ensembl
RefSeq Acc Id: XM_038441234   ⟹   XP_038297162
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02910,763,585 - 10,849,785 (-)NCBI
RefSeq Acc Id: XM_038515811   ⟹   XP_038371739
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12910,765,703 - 10,851,540 (-)NCBI
RefSeq Acc Id: XM_038579375   ⟹   XP_038435303
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02911,167,585 - 11,253,944 (-)NCBI
RefSeq Acc Id: XM_038643623   ⟹   XP_038499551
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02910,899,217 - 10,985,514 (-)NCBI
RefSeq Acc Id: XM_038643624   ⟹   XP_038499552
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02910,899,217 - 10,984,950 (-)NCBI
RefSeq Acc Id: XM_544094   ⟹   XP_544094
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12910,678,122 - 10,763,361 (-)NCBI
Dog10K_Boxer_Tasha2910,989,287 - 11,075,445 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_544094   ⟸   XM_544094
- Peptide Label: isoform X1
- UniProtKB: F1PWG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010611   ⟸   ENSCAFT00000011451
RefSeq Acc Id: ENSCAFP00000063044   ⟸   ENSCAFT00000075062
RefSeq Acc Id: XP_038371739   ⟸   XM_038515811
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038499551   ⟸   XM_038643623
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038499552   ⟸   XM_038643624
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038297162   ⟸   XM_038441234
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038435303   ⟸   XM_038579375
- Peptide Label: isoform X1
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:13688406
Promoter ID:EPDNEW_C6471
Type:single initiation site
Name:CA8_1
Description:carbonic anhydrase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12910,763,490 - 10,763,550EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007141 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000010611 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000063044 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011451 UniProtKB/TrEMBL
  ENSCAFT00000075062 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/TrEMBL
InterPro Carbonic_anhydrase_a UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/TrEMBL
  Carbonic_anhydrase_a_sf UniProtKB/TrEMBL
  CARP_VIII UniProtKB/TrEMBL
KEGG Report cfa:486965 UniProtKB/TrEMBL
NCBI Gene CA8 ENTREZGENE
PANTHER PTHR18952 UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
PROSITE ALPHA_CA_1 UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/TrEMBL
UniProt A0A5F4DB84_CANLF UniProtKB/TrEMBL
  F1PWG5 ENTREZGENE, UniProtKB/TrEMBL
  Q6JDM5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38616 ENTREZGENE