CTNS (cystinosin, lysosomal cystine transporter) - Rat Genome Database

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Gene: CTNS (cystinosin, lysosomal cystine transporter) Canis lupus familiaris
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Symbol: CTNS
Name: cystinosin, lysosomal cystine transporter
RGD ID: 12262691
Description: ENCODES a protein that exhibits solute:proton symporter activity (ortholog); INVOLVED IN adult walking behavior (ortholog); ATP metabolic process (ortholog); brain development (ortholog); PARTICIPATES IN cysteine metabolic pathway; mercaptolactate-cysteine disulfiduria pathway; ocular nonnephropathic cystinosis pathway; ASSOCIATED WITH Abderhalden-Kaufmann-Lignac Syndrome (ortholog); Canavan disease (ortholog); cystinosis (ortholog); FOUND IN early endosome (ortholog); intermediate filament cytoskeleton (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cystinosin; cystinosis, nephropathic
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1947,474,488 - 47,490,951 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl947,473,901 - 47,490,252 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha946,636,879 - 46,653,680 (+)NCBI
ROS_Cfam_1.0948,319,984 - 48,336,779 (+)NCBI
UMICH_Zoey_3.1947,097,771 - 47,114,551 (+)NCBI
UNSW_CanFamBas_1.0947,386,873 - 47,403,672 (+)NCBI
UU_Cfam_GSD_1.0947,442,508 - 47,459,300 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
CTNS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1947,474,488 - 47,490,951 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl947,473,901 - 47,490,252 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha946,636,879 - 46,653,680 (+)NCBI
ROS_Cfam_1.0948,319,984 - 48,336,779 (+)NCBI
UMICH_Zoey_3.1947,097,771 - 47,114,551 (+)NCBI
UNSW_CanFamBas_1.0947,386,873 - 47,403,672 (+)NCBI
UU_Cfam_GSD_1.0947,442,508 - 47,459,300 (+)NCBI
CTNS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl173,636,459 - 3,663,103 (+)EnsemblGRCh38hg38GRCh38
GRCh38173,636,459 - 3,663,103 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37173,539,753 - 3,566,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36173,486,511 - 3,513,146 (+)NCBINCBI36hg18NCBI36
Build 34173,486,764 - 3,511,581NCBI
Celera173,553,503 - 3,580,136 (+)NCBI
Cytogenetic Map17p13.2NCBI
HuRef173,431,470 - 3,458,104 (+)NCBIHuRef
CHM1_1173,550,519 - 3,577,033 (+)NCBICHM1_1
Ctns
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,073,959 - 73,089,869 (-)NCBIGRCm39mm39
GRCm39 Ensembl1173,074,422 - 73,089,868 (-)Ensembl
GRCm381173,183,133 - 73,199,115 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,183,596 - 73,199,042 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,996,635 - 73,012,521 (-)NCBIGRCm37mm9NCBIm37
MGSCv361172,999,328 - 73,015,214 (-)NCBImm8
Celera1180,720,225 - 80,736,105 (-)NCBICelera
Cytogenetic Map11B4NCBI
Ctns
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21057,801,551 - 57,817,213 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1057,801,456 - 57,817,120 (-)Ensembl
Rnor_6.01059,749,250 - 59,772,475 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,749,256 - 59,764,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01059,488,895 - 59,503,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41060,060,254 - 60,075,352 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11060,074,699 - 60,089,377 (-)NCBI
Celera1056,924,889 - 56,939,979 (-)NCBICelera
Cytogenetic Map10q24NCBI
Ctns
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546713,151,957 - 13,168,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546713,151,663 - 13,169,005 (-)NCBIChiLan1.0ChiLan1.0
CTNS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1173,683,562 - 3,708,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl173,683,575 - 3,708,253 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0173,686,903 - 3,711,857 (+)NCBIMhudiblu_PPA_v0panPan3
Ctns
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560255,540,083 - 55,557,805 (-)NCBI
SpeTri2.0NW_004936677342,964 - 360,890 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTNS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1249,730,955 - 49,753,208 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11249,730,741 - 49,754,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21251,592,126 - 51,613,331 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242158
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,138,716 - 3,164,512 (+)NCBI
ChlSab1.1 Ensembl163,138,734 - 3,164,625 (+)Ensembl
Vero_WHO_p1.0NW_02366605918,663,688 - 18,691,499 (-)NCBI
Ctns
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247866,296,975 - 6,318,266 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 19 3 6 3 6 10 8 10 6
Low 5 3 3 3 6 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000030743   ⟹   ENSCAFP00000028577
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl947,474,524 - 47,490,113 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060604   ⟹   ENSCAFP00000061625
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl947,474,524 - 47,490,252 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000079479   ⟹   ENSCAFP00000060649
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl947,473,901 - 47,490,252 (+)Ensembl
RefSeq Acc Id: XM_014116852   ⟹   XP_013972327
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1947,474,488 - 47,490,945 (+)NCBI
Dog10K_Boxer_Tasha946,636,879 - 46,653,680 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022423484   ⟹   XP_022279192
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1947,479,869 - 47,490,951 (+)NCBI
Dog10K_Boxer_Tasha946,642,578 - 46,653,680 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038486689   ⟹   XP_038342617
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1947,097,771 - 47,114,551 (+)NCBI
RefSeq Acc Id: XM_038486690   ⟹   XP_038342618
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1947,103,458 - 47,114,551 (+)NCBI
RefSeq Acc Id: XM_038548556   ⟹   XP_038404484
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0947,442,508 - 47,459,300 (+)NCBI
RefSeq Acc Id: XM_038548557   ⟹   XP_038404485
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0947,448,207 - 47,459,300 (+)NCBI
RefSeq Acc Id: XM_038612497   ⟹   XP_038468425
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0947,386,873 - 47,403,672 (+)NCBI
RefSeq Acc Id: XM_038612498   ⟹   XP_038468426
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0947,392,572 - 47,403,672 (+)NCBI
RefSeq Acc Id: XM_038677773   ⟹   XP_038533701
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0948,319,984 - 48,336,779 (+)NCBI
RefSeq Acc Id: XM_038677774   ⟹   XP_038533702
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0948,325,682 - 48,336,779 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_013972327   ⟸   XM_014116852
- Peptide Label: isoform X1
- UniProtKB: E2R8H4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022279192   ⟸   XM_022423484
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000028577   ⟸   ENSCAFT00000030743
RefSeq Acc Id: ENSCAFP00000061625   ⟸   ENSCAFT00000060604
RefSeq Acc Id: ENSCAFP00000060649   ⟸   ENSCAFT00000079479
RefSeq Acc Id: XP_038342617   ⟸   XM_038486689
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038342618   ⟸   XM_038486690
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038468425   ⟸   XM_038612497
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038468426   ⟸   XM_038612498
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038533701   ⟸   XM_038677773
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038533702   ⟸   XM_038677774
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038404484   ⟸   XM_038548556
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038404485   ⟸   XM_038548557
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019345 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000028577 ENTREZGENE
NCBI Gene CTNS ENTREZGENE
UniProt E2R8H4 ENTREZGENE
VGNC ID VGNC:39703 ENTREZGENE