SPARC (secreted protein acidic and cysteine rich) - Rat Genome Database

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Gene: SPARC (secreted protein acidic and cysteine rich) Canis lupus familiaris
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Symbol: SPARC
Name: secreted protein acidic and cysteine rich
RGD ID: 12259319
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN bone development (ortholog); cellular response to growth factor stimulus (ortholog); heart development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); adrenocortical carcinoma (ortholog); Brain Injuries (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: secreted protein, acidic, cysteine-rich (osteonectin)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,659,541 - 57,682,147 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,659,650 - 57,681,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,479,010 - 57,501,597 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,102,077 - 58,124,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,101,302 - 58,124,748 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1457,918,069 - 57,940,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,016,600 - 58,039,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,519,992 - 58,542,658 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SPARC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,659,541 - 57,682,147 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,659,650 - 57,681,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,479,010 - 57,501,597 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,102,077 - 58,124,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,101,302 - 58,124,748 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1457,918,069 - 57,940,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,016,600 - 58,039,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,519,992 - 58,542,658 (+)NCBIUU_Cfam_GSD_1.0
SPARC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,661,096 - 151,686,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,661,096 - 151,686,975 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,040,657 - 151,066,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,021,201 - 151,046,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 345151,021,203 - 151,046,710NCBI
Celera5147,122,406 - 147,147,929 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,186,043 - 146,212,010 (-)NCBIHuRef
CHM1_15150,473,070 - 150,499,042 (-)NCBICHM1_1
T2T-CHM13v2.05152,200,073 - 152,225,896 (-)NCBIT2T-CHM13v2.0
Sparc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,284,985 - 55,310,906 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,285,326 - 55,314,009 (-)EnsemblGRCm39 Ensembl
GRCm381155,394,159 - 55,420,080 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,394,500 - 55,423,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,208,003 - 55,233,582 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,237,924 - 55,263,289 (-)NCBIMGSCv36mm8
Celera1159,982,920 - 59,995,424 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1133.04NCBI
Sparc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,017,065 - 40,038,816 (-)NCBIGRCr8
mRatBN7.21039,516,394 - 39,538,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,200,679 - 44,221,761 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,690,774 - 43,711,860 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,194,463 - 39,215,539 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,742,390 - 40,764,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,573,510 - 40,595,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,809,730 - 40,831,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,823,352 - 40,845,104 (-)NCBI
Celera1038,848,158 - 38,869,906 (-)NCBICelera
RH 3.4 Map10414.6RGD
Cytogenetic Map10q22NCBI
Sparc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,099,003 - 6,122,459 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554086,100,123 - 6,122,460 (-)NCBIChiLan1.0ChiLan1.0
SPARC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,892,751 - 146,917,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15145,032,296 - 145,057,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05147,087,903 - 147,112,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15153,091,160 - 153,115,745 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,090,181 - 153,115,750 (-)Ensemblpanpan1.1panPan2
Sparc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,576,762 - 112,597,465 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651511,025,724 - 11,046,849 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651511,026,156 - 11,046,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPARC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,357,586 - 71,381,161 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,368,164 - 71,380,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,576,864 - 77,584,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPARC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,224,003 - 54,248,869 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,222,838 - 54,238,006 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603423,456,066 - 23,481,034 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sparc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,338,284 - 37,369,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,348,993 - 37,369,804 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SPARC
357 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 3 3 5 4
Medium 5 5 22 6 6 6 3 6 9 8 5 2
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000028332   ⟹   ENSCAFP00000026348
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl457,659,650 - 57,680,990 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000081564   ⟹   ENSCAFP00000060949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl457,659,650 - 57,681,029 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089469   ⟹   ENSCAFP00000065364
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl457,659,650 - 57,681,711 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845009245   ⟹   ENSCAFP00845007270
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl458,101,302 - 58,124,748 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845009260   ⟹   ENSCAFP00845007282
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl458,102,164 - 58,124,727 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845009262   ⟹   ENSCAFP00845007284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl458,107,769 - 58,124,739 (+)Ensembl
RefSeq Acc Id: XM_005619272   ⟹   XP_005619329
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1457,659,541 - 57,682,147 (+)NCBI
Dog10K_Boxer_Tasha457,479,010 - 57,501,597 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014113053   ⟹   XP_013968528
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1457,665,214 - 57,682,147 (+)NCBI
Dog10K_Boxer_Tasha457,484,666 - 57,501,597 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038473882   ⟹   XP_038329810
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1457,918,069 - 57,940,655 (+)NCBI
RefSeq Acc Id: XM_038473883   ⟹   XP_038329811
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1457,923,725 - 57,940,655 (+)NCBI
RefSeq Acc Id: XM_038534972   ⟹   XP_038390900
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0458,519,992 - 58,542,658 (+)NCBI
RefSeq Acc Id: XM_038534973   ⟹   XP_038390901
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0458,525,712 - 58,542,658 (+)NCBI
RefSeq Acc Id: XM_038599272   ⟹   XP_038455200
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0458,016,600 - 58,039,187 (+)NCBI
RefSeq Acc Id: XM_038599274   ⟹   XP_038455202
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0458,022,256 - 58,039,187 (+)NCBI
RefSeq Acc Id: XM_038663578   ⟹   XP_038519506
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0458,102,077 - 58,124,747 (+)NCBI
RefSeq Acc Id: XM_038663579   ⟹   XP_038519507
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0458,107,801 - 58,124,747 (+)NCBI
RefSeq Acc Id: XP_005619329   ⟸   XM_005619272
- UniProtKB: A0A8C0LID1 (UniProtKB/TrEMBL),   A0A8C0QBH2 (UniProtKB/TrEMBL),   A0A8I3MV86 (UniProtKB/TrEMBL),   A0A8P0TGU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013968528   ⟸   XM_014113053
- UniProtKB: A0A8C0LID1 (UniProtKB/TrEMBL),   A0A8C0QBH2 (UniProtKB/TrEMBL),   A0A8I3MV86 (UniProtKB/TrEMBL),   A0A8P0TGU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000026348   ⟸   ENSCAFT00000028332
RefSeq Acc Id: ENSCAFP00000065364   ⟸   ENSCAFT00000089469
RefSeq Acc Id: ENSCAFP00000060949   ⟸   ENSCAFT00000081564
RefSeq Acc Id: XP_038329810   ⟸   XM_038473882
RefSeq Acc Id: XP_038329811   ⟸   XM_038473883
RefSeq Acc Id: XP_038455200   ⟸   XM_038599272
RefSeq Acc Id: XP_038455202   ⟸   XM_038599274
RefSeq Acc Id: XP_038519506   ⟸   XM_038663578
- UniProtKB: A0A8C0LID1 (UniProtKB/TrEMBL),   A0A8C0QBH2 (UniProtKB/TrEMBL),   A0A8I3MV86 (UniProtKB/TrEMBL),   A0A8P0TGU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519507   ⟸   XM_038663579
- UniProtKB: A0A8C0LID1 (UniProtKB/TrEMBL),   A0A8C0QBH2 (UniProtKB/TrEMBL),   A0A8I3MV86 (UniProtKB/TrEMBL),   A0A8P0TGU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390900   ⟸   XM_038534972
- UniProtKB: A0A8C0LID1 (UniProtKB/TrEMBL),   A0A8C0QBH2 (UniProtKB/TrEMBL),   A0A8I3MV86 (UniProtKB/TrEMBL),   A0A8P0TGU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390901   ⟸   XM_038534973
- UniProtKB: A0A8C0LID1 (UniProtKB/TrEMBL),   A0A8C0QBH2 (UniProtKB/TrEMBL),   A0A8I3MV86 (UniProtKB/TrEMBL),   A0A8P0TGU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007282   ⟸   ENSCAFT00845009260
RefSeq Acc Id: ENSCAFP00845007284   ⟸   ENSCAFT00845009262
RefSeq Acc Id: ENSCAFP00845007270   ⟸   ENSCAFT00845009245
Protein Domains
Kazal-like

Promoters
RGD ID:13683013
Promoter ID:EPDNEW_C1081
Type:initiation region
Name:SPARC_1
Description:secreted protein acidic and cysteine rich
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1457,659,636 - 57,659,696EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017855 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003814 UniProtKB/TrEMBL
  ENSCAFG00040007293 UniProtKB/TrEMBL
  ENSCAFG00845005166 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028332.5 UniProtKB/TrEMBL
  ENSCAFT00000089469.2 UniProtKB/TrEMBL
  ENSCAFT00030007097.1 UniProtKB/TrEMBL
  ENSCAFT00030007194.1 UniProtKB/TrEMBL
  ENSCAFT00040013565.1 UniProtKB/TrEMBL
  ENSCAFT00040013610.1 UniProtKB/TrEMBL
  ENSCAFT00040013649.1 UniProtKB/TrEMBL
  ENSCAFT00845009245.1 UniProtKB/TrEMBL
  ENSCAFT00845009260 ENTREZGENE
  ENSCAFT00845009260.1 UniProtKB/TrEMBL
  ENSCAFT00845009262 ENTREZGENE
  ENSCAFT00845009262.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  Fol_N UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  Osteonectin_CS UniProtKB/TrEMBL
  SPARC UniProtKB/TrEMBL
  SPARC/Testican_Ca-bd-dom UniProtKB/TrEMBL
KEGG Report cfa:100855736 UniProtKB/TrEMBL
NCBI Gene SPARC ENTREZGENE
PANTHER PTHR13866:SF6 UniProtKB/TrEMBL
  SPARC OSTEONECTIN UniProtKB/TrEMBL
Pfam FOLN UniProtKB/TrEMBL
  Kazal_1 UniProtKB/TrEMBL
  SPARC_Ca_bdg UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
  OSTEONECTIN_1 UniProtKB/TrEMBL
  OSTEONECTIN_2 UniProtKB/TrEMBL
SMART FOLN UniProtKB/TrEMBL
  KAZAL UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF100895 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt A0A8C0LID1 ENTREZGENE
  A0A8C0QBE3_CANLF UniProtKB/TrEMBL
  A0A8C0QBH2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S006_CANLF UniProtKB/TrEMBL
  A0A8I3MV86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MWE5_CANLF UniProtKB/TrEMBL
  A0A8I3MWF4_CANLF UniProtKB/TrEMBL
  A0A8P0SM70_CANLF UniProtKB/TrEMBL
  A0A8P0TGU7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46701 ENTREZGENE