LOC480667 (endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase) - Rat Genome Database

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Gene: LOC480667 (endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase) Canis lupus familiaris
Analyze
Symbol: LOC480667 (Ensembl: MAN1B1)
Name: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
RGD ID: 12257439
Description: ENCODES a protein that exhibits alpha-mannosidase activity (inferred); calcium ion binding (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN ERAD pathway (ortholog); mannoprotein catabolic process (ortholog); ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN cytoplasmic vesicle (ortholog); endoplasmic reticulum quality control compartment (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like; LOC607002; LOC608032; MAN1B1; mannosidase, alpha, class 1B, member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,533,962 - 48,545,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,533,962 - 48,545,344 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,726,966 - 47,738,670 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,401,870 - 49,413,599 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1948,178,182 - 48,189,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,476,984 - 48,488,658 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,524,211 - 48,535,917 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC480667
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,533,962 - 48,545,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,533,962 - 48,545,344 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,726,966 - 47,738,670 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,401,870 - 49,413,599 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1948,178,182 - 48,189,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,476,984 - 48,488,658 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,524,211 - 48,535,917 (+)NCBIUU_Cfam_GSD_1.0
MAN1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,086,985 - 137,109,183 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,086,857 - 137,109,189 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,981,437 - 140,003,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,101,200 - 139,123,460 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,257,215 - 137,279,476NCBI
Celera9110,494,869 - 110,517,868 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,441,072 - 109,464,974 (+)NCBIHuRef
CHM1_19140,130,181 - 140,152,419 (+)NCBICHM1_1
T2T-CHM13v2.09149,322,873 - 149,347,137 (+)NCBIT2T-CHM13v2.0
Man1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,222,742 - 25,242,225 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,222,350 - 25,242,224 (+)EnsemblGRCm39 Ensembl
GRCm38225,332,730 - 25,352,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,332,338 - 25,352,212 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,188,263 - 25,207,733 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,154,765 - 25,174,221 (+)NCBIMGSCv36mm8
Celera225,060,285 - 25,079,751 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.17NCBI
Man1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,539,778 - 28,563,155 (+)NCBIGRCr8
mRatBN7.238,143,877 - 8,165,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,143,381 - 8,165,006 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,248,895 - 11,270,140 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,835,125 - 19,856,370 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,024,968 - 18,046,213 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,547,259 - 2,569,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,547,986 - 2,569,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,528,747 - 2,550,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,493,476 - 3,514,884 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera32,970,480 - 2,991,187 (+)NCBICelera
Cytogenetic Map3p13NCBI
Man1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,111,046 - 5,122,442 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,109,651 - 5,122,568 (-)NCBIChiLan1.0ChiLan1.0
MAN1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,290,146 - 2,312,954 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,292,479 - 2,313,502 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,148,020 - 108,168,931 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,117,150 - 137,139,066 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,118,361 - 137,139,066 (+)Ensemblpanpan1.1panPan2
Man1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,507,291 - 202,519,741 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669855,340 - 871,516 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669855,349 - 867,763 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110258087
(Sus scrofa - pig)		 No map positions available.
MAN1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,080,492 - 1,104,981 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,080,305 - 1,105,027 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,199,294 - 4,223,592 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Man1b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760813,045 - 825,153 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760813,657 - 826,020 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LOC480667
165 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 22 6 6 6 6 12 10 6
Low 5 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000031023   ⟹   ENSCAFP00000028856
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,533,962 - 48,545,344 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000084367   ⟹   ENSCAFP00000047282
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,533,962 - 48,544,991 (+)Ensembl
RefSeq Acc Id: XM_038486817   ⟹   XP_038342745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1948,178,182 - 48,189,888 (+)NCBI
RefSeq Acc Id: XM_038548686   ⟹   XP_038404614
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0948,524,211 - 48,535,917 (+)NCBI
RefSeq Acc Id: XM_038612622   ⟹   XP_038468550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0948,476,984 - 48,488,658 (+)NCBI
RefSeq Acc Id: XM_038677908   ⟹   XP_038533836
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,401,870 - 49,413,599 (+)NCBI
RefSeq Acc Id: XM_537786   ⟹   XP_537786
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,533,962 - 48,545,514 (+)NCBI
Dog10K_Boxer_Tasha947,726,966 - 47,738,670 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_537786   ⟸   XM_537786
- Peptide Label: isoform X1
- UniProtKB: A0A8C0YX74 (UniProtKB/TrEMBL),   A0A8P0SNJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000047282   ⟸   ENSCAFT00000084367
RefSeq Acc Id: ENSCAFP00000028856   ⟸   ENSCAFT00000031023
RefSeq Acc Id: XP_038342745   ⟸   XM_038486817
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038468550   ⟸   XM_038612622
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038533836   ⟸   XM_038677908
- Peptide Label: isoform X1
- UniProtKB: A0A8C0YX74 (UniProtKB/TrEMBL),   A0A8P0SNJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404614   ⟸   XM_038548686
- Peptide Label: isoform X1
- UniProtKB: A0A8C0YX74 (UniProtKB/TrEMBL),   A0A8P0SNJ1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019517 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005107 UniProtKB/TrEMBL
  ENSCAFG00030005259 UniProtKB/TrEMBL
  ENSCAFG00040012814 UniProtKB/TrEMBL
  ENSCAFG00845024757 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031023.5 UniProtKB/TrEMBL
  ENSCAFT00000084367.2 UniProtKB/TrEMBL
  ENSCAFT00000105909.1 UniProtKB/TrEMBL
  ENSCAFT00030009371.1 UniProtKB/TrEMBL
  ENSCAFT00030009421.1 UniProtKB/TrEMBL
  ENSCAFT00030009605.1 UniProtKB/TrEMBL
  ENSCAFT00040023617.1 UniProtKB/TrEMBL
  ENSCAFT00040023686.1 UniProtKB/TrEMBL
  ENSCAFT00040023775.1 UniProtKB/TrEMBL
  ENSCAFT00845043679 ENTREZGENE
  ENSCAFT00845043679.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  Glyco_hydro_47 UniProtKB/TrEMBL
  Seven-hairpin_glycosidases UniProtKB/TrEMBL
KEGG Report cfa:480667 UniProtKB/TrEMBL
NCBI Gene LOC480667 ENTREZGENE
PANTHER ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE UniProtKB/TrEMBL
  MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED UniProtKB/TrEMBL
Pfam Glyco_hydro_47 UniProtKB/TrEMBL
PRINTS GLYHDRLASE47 UniProtKB/TrEMBL
Superfamily-SCOP SSF48225 UniProtKB/TrEMBL
UniProt A0A8C0MEJ9_CANLF UniProtKB/TrEMBL
  A0A8C0SEY8_CANLF UniProtKB/TrEMBL
  A0A8C0SH60_CANLF UniProtKB/TrEMBL
  A0A8C0YX74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q4Z8_CANLF UniProtKB/TrEMBL
  A0A8P0SNJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0T0B6_CANLF UniProtKB/TrEMBL
  A0A8P0TUU8_CANLF UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 LOC480667  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase  LOC607002  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like  Data merged from RGD:12313813 737654 PROVISIONAL
2021-01-14 LOC480667  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase  LOC608032  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like  Data merged from RGD:12331434 737654 PROVISIONAL