AGO4 (argonaute RISC component 4) - Rat Genome Database

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Gene: AGO4 (argonaute RISC component 4) Canis lupus familiaris
Analyze
Symbol: AGO4 (Ensembl: AGO3)
Name: argonaute RISC component 4 (Ensembl:argonaute RISC catalytic component 3)
RGD ID: 12251798
Description: ENCODES a protein that exhibits double-stranded RNA binding (ortholog); INVOLVED IN male gonad development (ortholog); male meiotic nuclear division (ortholog); miRNA metabolic process (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); FOUND IN cytoplasmic ribonucleoprotein granule (ortholog); cytosol (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4; EIF2C4; eukaryotic translation initiation factor 2C, 4; protein argonaute-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,325,899 - 6,351,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,329,413 - 6,356,676 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,569,069 - 6,608,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,462,261 - 6,501,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,281,474 - 6,502,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,315,003 - 6,354,575 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,383,741 - 6,423,313 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,398,098 - 6,437,686 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
AGO4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,325,899 - 6,351,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,329,413 - 6,356,676 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,569,069 - 6,608,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,462,261 - 6,501,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,281,474 - 6,502,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,315,003 - 6,354,575 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,383,741 - 6,423,313 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,398,098 - 6,437,686 (-)NCBIUU_Cfam_GSD_1.0
AGO4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,807,636 - 35,857,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,808,016 - 35,857,890 (+)EnsemblGRCh38hg38GRCh38
GRCh37136,273,237 - 36,323,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,046,415 - 36,093,775 (+)NCBINCBI36Build 36hg18NCBI36
Build 34135,942,920 - 35,990,281NCBI
Celera134,548,288 - 34,595,633 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,391,417 - 34,441,140 (+)NCBIHuRef
CHM1_1136,390,239 - 36,439,851 (+)NCBICHM1_1
T2T-CHM13v2.0135,670,525 - 35,720,783 (+)NCBIT2T-CHM13v2.0
Ago4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,383,280 - 126,427,379 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,383,334 - 126,427,265 (-)EnsemblGRCm39 Ensembl
GRCm384126,489,487 - 126,533,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,489,541 - 126,533,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,166,785 - 126,210,702 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,994,456 - 126,035,544 (-)NCBIMGSCv36mm8
Celera4124,826,342 - 124,870,087 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.9NCBI
Ago4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,064,949 - 144,110,422 (-)NCBIGRCr8
mRatBN7.25138,780,446 - 138,825,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,783,069 - 138,825,632 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,477,953 - 141,523,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,247,944 - 143,293,406 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,248,730 - 143,294,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,501,875 - 144,557,165 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,504,938 - 144,556,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,269,991 - 148,328,500 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,857,594 - 145,902,950 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,866,645 - 145,932,628 (-)NCBI
Celera5137,279,250 - 137,322,143 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ago4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,882,416 - 13,922,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,882,416 - 13,922,590 (+)NCBIChiLan1.0ChiLan1.0
LOC100977537
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,990,660 - 191,040,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,111,850 - 190,161,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,072,045 - 35,122,418 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,249,040 - 36,299,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,249,038 - 36,299,259 (+)Ensemblpanpan1.1panPan2
Ago4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505852,510,754 - 52,548,926 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647418,335,531 - 18,370,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647418,335,536 - 18,371,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGO4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,973,119 - 92,012,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1691,967,499 - 92,013,030 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2685,255,835 - 85,296,920 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGO4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12097,001,484 - 97,056,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2097,003,566 - 97,056,051 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603319,672,650 - 19,725,326 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,838,920 - 18,883,894 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,838,887 - 18,883,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AGO4
115 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 4 5 4 2 5
Low 4 5 18 6 1 6 2 6 10 8 5 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022427854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038451698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038451699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038495572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038495573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038557924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038557925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038621797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038621798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000005657   ⟹   ENSCAFP00000005237
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl156,329,413 - 6,356,676 (-)Ensembl
RefSeq Acc Id: XM_038451698   ⟹   XP_038307626
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha156,569,069 - 6,608,633 (-)NCBI
RefSeq Acc Id: XM_038451699   ⟹   XP_038307627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha156,569,069 - 6,599,784 (-)NCBI
RefSeq Acc Id: XM_038495572   ⟹   XP_038351500
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1156,315,003 - 6,354,575 (-)NCBI
RefSeq Acc Id: XM_038495573   ⟹   XP_038351501
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1156,315,003 - 6,345,739 (-)NCBI
RefSeq Acc Id: XM_038557924   ⟹   XP_038413852
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0156,398,098 - 6,437,686 (-)NCBI
RefSeq Acc Id: XM_038557925   ⟹   XP_038413853
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0156,398,098 - 6,428,819 (-)NCBI
RefSeq Acc Id: XM_038621797   ⟹   XP_038477725
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0156,383,741 - 6,423,313 (-)NCBI
RefSeq Acc Id: XM_038621798   ⟹   XP_038477726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0156,383,741 - 6,414,478 (-)NCBI
RefSeq Acc Id: XM_038687564   ⟹   XP_038543492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0156,462,261 - 6,501,884 (-)NCBI
RefSeq Acc Id: XM_038687565   ⟹   XP_038543493
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0156,462,261 - 6,493,011 (-)NCBI
RefSeq Acc Id: ENSCAFP00000005237   ⟸   ENSCAFT00000005657
RefSeq Acc Id: XP_038351500   ⟸   XM_038495572
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038351501   ⟸   XM_038495573
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038477725   ⟸   XM_038621797
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038477726   ⟸   XM_038621798
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038543492   ⟸   XM_038687564
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QCJ7 (UniProtKB/TrEMBL),   A0A8C0QI45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543493   ⟸   XM_038687565
- Peptide Label: isoform X2
- UniProtKB: A0A8I3Q8A7 (UniProtKB/TrEMBL),   A0A8P0S983 (UniProtKB/TrEMBL),   A0A8C0QI45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038307626   ⟸   XM_038451698
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QCJ7 (UniProtKB/TrEMBL),   A0A8C0QI45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038307627   ⟸   XM_038451699
- Peptide Label: isoform X2
- UniProtKB: A0A8I3Q8A7 (UniProtKB/TrEMBL),   A0A8P0S983 (UniProtKB/TrEMBL),   A0A8C0QI45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038413852   ⟸   XM_038557924
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QCJ7 (UniProtKB/TrEMBL),   A0A8C0QI45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038413853   ⟸   XM_038557925
- Peptide Label: isoform X2
- UniProtKB: A0A8C0QI45 (UniProtKB/TrEMBL),   A0A8I3Q8A7 (UniProtKB/TrEMBL),   A0A8P0S983 (UniProtKB/TrEMBL)
Protein Domains
PAZ   Piwi


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000024306 Ensembl
  ENSCAFG00000024682 UniProtKB/TrEMBL
  ENSCAFG00030017465 UniProtKB/TrEMBL
  ENSCAFG00040006996 UniProtKB/TrEMBL
  ENSCAFG00845030956 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005657.6 UniProtKB/TrEMBL
  ENSCAFT00030032265.1 UniProtKB/TrEMBL
  ENSCAFT00040012984.1 UniProtKB/TrEMBL
  ENSCAFT00040013582.1 UniProtKB/TrEMBL
  ENSCAFT00845055019.1 UniProtKB/TrEMBL
  ENSCAFT00845055046.1 UniProtKB/TrEMBL
  ENSCAFT00845055066.1 UniProtKB/TrEMBL
  ENSCAFT00845055070 ENTREZGENE
  ENSCAFT00845055070.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  paz domain UniProtKB/TrEMBL
InterPro AGO4 UniProtKB/TrEMBL
  ArgoL1 UniProtKB/TrEMBL
  ArgoL2 UniProtKB/TrEMBL
  Argonaute_Mid_dom UniProtKB/TrEMBL
  Argonaute_N UniProtKB/TrEMBL
  PAZ_dom UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
  Piwi_ago-like UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
NCBI Gene AGO4 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/TrEMBL
  PROTEIN ARGONAUTE-3 UniProtKB/TrEMBL
  PROTEIN ARGONAUTE-4 UniProtKB/TrEMBL
Pfam ArgoL1 UniProtKB/TrEMBL
  ArgoL2 UniProtKB/TrEMBL
  ArgoMid UniProtKB/TrEMBL
  ArgoN UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
PROSITE PAZ UniProtKB/TrEMBL
  PIWI UniProtKB/TrEMBL
SMART DUF1785 UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
Superfamily-SCOP SSF101690 UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
UniProt A0A8C0QCJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QI45 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q8A7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QBA5_CANLF UniProtKB/TrEMBL
  A0A8I3QDG6_CANLF UniProtKB/TrEMBL
  A0A8I3S7W4_CANLF UniProtKB/TrEMBL
  A0A8P0S983 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37709 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 AGO4  argonaute RISC component 4    argonaute RISC catalytic component 4  Symbol and/or name change 5135510 APPROVED
2019-01-22 AGO4  argonaute RISC catalytic component 4    argonaute 4, RISC catalytic component  Symbol and/or name change 5135510 APPROVED