CERK (ceramide kinase) - Rat Genome Database

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Gene: CERK (ceramide kinase) Canis lupus familiaris
Analyze
Symbol: CERK
Name: ceramide kinase
RGD ID: 12251127
Description: ENCODES a protein that exhibits ceramide kinase activity (inferred); kinase activity (inferred); magnesium ion binding (inferred); INVOLVED IN ceramide metabolic process (inferred); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,560,125 - 19,601,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,556,087 - 19,598,954 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1019,480,876 - 19,522,720 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01020,294,959 - 20,336,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,294,760 - 20,336,829 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,013,088 - 20,054,908 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,325,241 - 20,367,020 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,507,050 - 20,548,676 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
CERK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,560,125 - 19,601,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,556,087 - 19,598,954 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1019,480,876 - 19,522,720 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01020,294,959 - 20,336,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,294,760 - 20,336,829 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,013,088 - 20,054,908 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,325,241 - 20,367,020 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,507,050 - 20,548,676 (+)NCBIUU_Cfam_GSD_1.0
CERK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,684,410 - 46,738,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,684,410 - 46,738,252 (-)EnsemblGRCh38hg38GRCh38
GRCh372247,080,307 - 47,134,149 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362245,458,971 - 45,512,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 342245,400,826 - 45,406,632NCBI
Celera2230,995,999 - 31,049,854 (-)NCBICelera
Cytogenetic Map22q13.31NCBI
HuRef2230,025,258 - 30,079,178 (-)NCBIHuRef
CHM1_12247,039,226 - 47,093,493 (-)NCBICHM1_1
T2T-CHM13v2.02247,172,367 - 47,226,215 (-)NCBIT2T-CHM13v2.0
Cerk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391586,023,302 - 86,070,537 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1586,023,329 - 86,070,342 (-)EnsemblGRCm39 Ensembl
GRCm381586,139,101 - 86,186,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1586,139,128 - 86,186,141 (-)EnsemblGRCm38mm10GRCm38
MGSCv371585,969,531 - 86,016,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361585,966,895 - 86,013,907 (-)NCBIMGSCv36mm8
MGSCv361586,937,923 - 86,985,654 (-)NCBIMGSCv36mm8
Celera1588,281,909 - 88,328,692 (-)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.52NCBI
Cerk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87119,105,674 - 119,149,885 (-)NCBIGRCr8
mRatBN7.27117,225,855 - 117,269,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7117,225,855 - 117,268,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,977,337 - 119,020,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07121,202,971 - 121,245,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07121,172,546 - 121,215,466 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07127,015,162 - 127,058,056 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7127,015,162 - 127,058,056 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,726,021 - 126,768,650 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47124,139,137 - 124,182,070 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17124,173,366 - 124,216,042 (-)NCBI
Celera7113,516,253 - 113,558,934 (-)NCBICelera
Cytogenetic Map7q34NCBI
Cerk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,660,593 - 30,679,674 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,658,472 - 30,693,948 (-)NCBIChiLan1.0ChiLan1.0
CERK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22356,524,324 - 56,580,132 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12259,215,963 - 59,271,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02226,849,865 - 26,905,545 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12245,749,887 - 45,786,570 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,749,887 - 45,786,570 (-)Ensemblpanpan1.1panPan2
Cerk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049453,304,236 - 3,346,264 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,304,236 - 3,344,136 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,304,236 - 3,346,264 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CERK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl52,818,784 - 2,870,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.152,818,738 - 2,870,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CERK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11929,183,324 - 29,236,857 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604596,276,619 - 96,355,869 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cerk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247523,285,637 - 3,326,738 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247523,285,649 - 3,328,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CERK
798 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 16 6 6 12 8 10 6
Low 6 6 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001158   ⟹   ENSCAFP00000001057
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1019,556,087 - 19,598,954 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000046855   ⟹   ENSCAFP00000038639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1019,560,027 - 19,598,954 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015861   ⟹   ENSCAFP00845012340
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1020,294,760 - 20,336,829 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015936   ⟹   ENSCAFP00845012399
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1020,294,760 - 20,336,829 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015973   ⟹   ENSCAFP00845012426
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1020,298,668 - 20,336,829 (+)Ensembl
RefSeq Acc Id: XM_038489570   ⟹   XP_038345498
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11020,013,088 - 20,054,908 (+)NCBI
RefSeq Acc Id: XM_038551559   ⟹   XP_038407487
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01020,507,050 - 20,548,676 (+)NCBI
RefSeq Acc Id: XM_038613505   ⟹   XP_038469433
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01020,325,241 - 20,367,020 (+)NCBI
RefSeq Acc Id: XM_038640587   ⟹   XP_038496515
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1019,480,876 - 19,522,720 (+)NCBI
RefSeq Acc Id: XM_038678875   ⟹   XP_038534803
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01020,294,959 - 20,336,847 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000001057   ⟸   ENSCAFT00000001158
RefSeq Acc Id: ENSCAFP00000038639   ⟸   ENSCAFT00000046855
RefSeq Acc Id: XP_038345498   ⟸   XM_038489570
RefSeq Acc Id: XP_038469433   ⟸   XM_038613505
RefSeq Acc Id: XP_038534803   ⟸   XM_038678875
- UniProtKB: A0A8C0K7E1 (UniProtKB/TrEMBL),   A0A8C0MSI8 (UniProtKB/TrEMBL),   A0A8I3N5N8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038496515   ⟸   XM_038640587
- UniProtKB: A0A8C0K7E1 (UniProtKB/TrEMBL),   A0A8C0MSI8 (UniProtKB/TrEMBL),   A0A8I3N5N8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407487   ⟸   XM_038551559
- UniProtKB: A0A8C0K7E1 (UniProtKB/TrEMBL),   A0A8C0MSI8 (UniProtKB/TrEMBL),   A0A8I3N5N8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845012340   ⟸   ENSCAFT00845015861
RefSeq Acc Id: ENSCAFP00845012426   ⟸   ENSCAFT00845015973
RefSeq Acc Id: ENSCAFP00845012399   ⟸   ENSCAFT00845015936
Protein Domains
DAGKc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000752 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008738 UniProtKB/TrEMBL
  ENSCAFG00040006622 UniProtKB/TrEMBL
  ENSCAFG00845009002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001158.6 UniProtKB/TrEMBL
  ENSCAFT00000046855.3 UniProtKB/TrEMBL
  ENSCAFT00000109210.1 UniProtKB/TrEMBL
  ENSCAFT00030016226.1 UniProtKB/TrEMBL
  ENSCAFT00030016264.1 UniProtKB/TrEMBL
  ENSCAFT00040012349.1 UniProtKB/TrEMBL
  ENSCAFT00845015861.1 UniProtKB/TrEMBL
  ENSCAFT00845015936 ENTREZGENE
  ENSCAFT00845015936.1 UniProtKB/TrEMBL
  ENSCAFT00845015973.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.40 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/TrEMBL
  CERK_C UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/TrEMBL
NCBI Gene CERK ENTREZGENE
PANTHER CERAMIDE KINASE UniProtKB/TrEMBL
  SPHINGOSINE KINASE UniProtKB/TrEMBL
Pfam CERK_C UniProtKB/TrEMBL
  DAGK_cat UniProtKB/TrEMBL
PROSITE DAGK UniProtKB/TrEMBL
SMART DAGKc UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
UniProt A0A8C0K7E1 ENTREZGENE
  A0A8C0MSI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MTE2_CANLF UniProtKB/TrEMBL
  A0A8I3N177_CANLF UniProtKB/TrEMBL
  A0A8I3N5N8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NA60_CANLF UniProtKB/TrEMBL
  A0A8P0S6Q3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54519 ENTREZGENE