PTS (6-pyruvoyltetrahydropterin synthase)

Advanced Search (OLGA)

Gene: PTS (6-pyruvoyltetrahydropterin synthase) Canis lupus familiaris

Analyze

Symbol:

PTS (Ensembl: BCO2)

Name:

6-pyruvoyltetrahydropterin synthase (Ensembl:beta-carotene oxygenase 2)

RGD ID:

12250918

Description:

ENCODES a protein that exhibits 6-pyruvoyltetrahydropterin synthase activity (ortholog); identical protein binding (ortholog); INVOLVED IN tetrahydrobiopterin biosynthetic process (ortholog); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; ASSOCIATED WITH BH4-deficient hyperphenylalaninemia A (ortholog); BH4-deficient hyperphenylalaninemia B (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); FOUND IN cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

6-pyruvoyl tetrahydrobiopterin synthase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	20,883,128 - 20,912,318 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	20,896,236 - 20,912,297 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	20,828,713 - 20,835,800 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	20,928,161 - 20,935,247 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	20,919,161 - 20,987,893 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	20,991,102 - 20,998,175 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	20,891,374 - 20,898,446 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	20,917,631 - 20,946,631 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

BH4-deficient hyperphenylalaninemia A (ISO)

BH4-deficient hyperphenylalaninemia B (ISO)

Chromosome 11, Partial Trisomy 11q (ISO)

disease of metabolism (ISO)

epilepsy (ISO)

genetic disease (ISO)

Hyperphenylalaninemia, BH4-Deficient, due to Partial PTS Deficiency (ISO)

intellectual disability (ISO)

phenylketonuria (ISO)

Pyruvate Dehydrogenase E2 Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carotene catabolic process (IEA)

carotene metabolic process (IEA)

carotenoid metabolic process (IEA)

regulation of mitochondrial membrane potential (IEA)

regulation of reactive oxygen species metabolic process (IEA)

retinal metabolic process (IEA)

tetrahydrobiopterin biosynthetic process (IEA,ISO)

xanthophyll catabolic process (IEA)

xanthophyll metabolic process (IEA)

Cellular Component

cytoplasm (ISO)

mitochondrion (IEA)

Molecular Function

6-pyruvoyltetrahydropterin synthase activity (IEA,ISO)

beta,beta-carotene-9',10'-cleaving oxygenase activity (IEA)

identical protein binding (ISO)

lyase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

dopa responsive dystonia pathway (ISO)

Segawa syndrome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PTS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	20,883,128 - 20,912,318 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	20,896,236 - 20,912,297 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	20,828,713 - 20,835,800 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	20,928,161 - 20,935,247 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	20,919,161 - 20,987,893 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	20,991,102 - 20,998,175 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	20,891,374 - 20,898,446 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	20,917,631 - 20,946,631 (-)	NCBI		UU_Cfam_GSD_1.0

PTS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	112,226,428 - 112,233,973 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	112,226,367 - 112,269,955 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	112,097,151 - 112,104,696 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	111,602,309 - 111,609,903 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	111,602,308 - 111,609,903	NCBI
Celera	11	109,250,329 - 109,257,937 (+)	NCBI		Celera
Cytogenetic Map	11	q23.1	NCBI
HuRef	11	108,022,655 - 108,030,262 (+)	NCBI		HuRef
CHM1_1	11	111,980,551 - 111,988,158 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	112,236,776 - 112,368,893 (+)	NCBI		T2T-CHM13v2.0

Pts
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	50,432,917 - 50,440,017 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	50,432,917 - 50,440,024 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	50,521,617 - 50,528,716 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	50,521,617 - 50,528,724 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	50,329,722 - 50,336,746 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	50,273,847 - 50,280,871 (-)	NCBI		MGSCv36	mm8
Celera	9	47,811,421 - 47,818,445 (-)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	27.73	NCBI

Pts
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	59,767,234 - 59,774,265 (-)	NCBI		GRCr8
mRatBN7.2	8	50,870,838 - 50,877,869 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	50,870,841 - 50,877,869 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	56,376,420 - 56,383,401 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	54,655,319 - 54,662,300 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	52,519,589 - 52,526,570 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	54,954,261 - 54,961,271 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	54,954,226 - 54,961,265 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	53,551,584 - 53,558,594 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	53,880,701 - 53,887,711 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	53,899,754 - 53,906,765 (-)	NCBI
Celera	8	50,419,474 - 50,426,475 (-)	NCBI		Celera
Cytogenetic Map	8	q23	NCBI

Pts
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	13,880,937 - 13,888,562 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	13,880,937 - 13,888,562 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	112,971,384 - 112,978,838 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	114,065,773 - 114,073,257 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	107,107,114 - 107,114,594 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	110,949,714 - 110,957,599 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	110,949,708 - 110,957,599 (+)	Ensembl	panpan1.1		panPan2

Pts
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	94,451,940 - 94,458,598 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	2,246,878 - 2,253,675 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	2,247,825 - 2,255,277 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	39,920,273 - 39,928,634 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	39,920,157 - 39,927,804 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	44,771,647 - 44,779,304 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	103,574,057 - 103,581,944 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	103,574,451 - 103,582,924 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	22,404,405 - 22,412,377 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pts
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	7,360,344 - 7,370,042 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	7,360,655 - 7,424,357 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PTS
295 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038474408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038536145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038536146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038536147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038602891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038664868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_848983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001316187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002626490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005359283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005359284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000022074 ⟹ ENSCAFP00000020498

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	5	20,905,692 - 20,912,297 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000042885 ⟹ ENSCAFP00000039935

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	5	20,896,236 - 20,912,297 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000080481 ⟹ ENSCAFP00000058486

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	5	20,906,449 - 20,912,297 (-)	Ensembl

RefSeq Acc Id:

XM_038474408 ⟹ XP_038330336

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	20,991,102 - 20,998,175 (-)	NCBI

RefSeq Acc Id:

XM_038536145 ⟹ XP_038392073

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	20,929,060 - 20,946,631 (-)	NCBI

RefSeq Acc Id:

XM_038536146 ⟹ XP_038392074

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	20,930,721 - 20,946,631 (-)	NCBI

RefSeq Acc Id:

XM_038536147 ⟹ XP_038392075

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	20,939,516 - 20,946,631 (-)	NCBI

RefSeq Acc Id:

XM_038602891 ⟹ XP_038458819

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	20,891,374 - 20,898,446 (-)	NCBI

RefSeq Acc Id:

XM_038664868 ⟹ XP_038520796

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	20,928,161 - 20,935,247 (-)	NCBI

RefSeq Acc Id:

XM_848983 ⟹ XP_854076

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	20,905,228 - 20,912,318 (-)	NCBI
Dog10K_Boxer_Tasha	5	20,828,713 - 20,835,800 (-)	NCBI

Sequence:

show sequence

CGTCACCGCGGGAAGGCGAGGCGATGAGCGGGGAGGGCGGCGGCGGCGGCGGCGGCGGGGGGCG
CCGCAGGGCGCGAGTGTCCCGCCTCGTCTCCTTCAGCGCCACCCACCGACTCCACAGCAAATCT
CTGAGTAATGAAGAAAACTTGAAACTGTTTGGGAAATGCAACAATCCAAATGGCCATGGGCACA
ATTATAAAGTTGTGGTGACAGTGCATGGAGAGATTGATCCTGTTACAGGAATGGTTATGAACTT
GACCGACCTCAAAGAATATATGGAGGAGGCAATTATGAAGCCCCTTGATCACAAGAATCTGGAT
CTGGATGTACCATACTTTGCAGATGTGGTAAGCACAACAGAAAATGTAGCTGTATATATCTGGG
AAAACCTCCAGAAATTTCTTCCTCTGGGAGTTCTTTATAAAGTAAAAGTATATGAAACTGACAA
TAATATTGTTGTCTATAAAGGAGAGTAGCTTTTAGGAGATAATACTGTAGAAAGACTAATTTCT
TTCTATTTGAAAAAGGTCTTCATCCCCCCGGACTATTAAGTCATCACATACTTGTTATGCCTTC
ACACTGTGTTCTAGAGTGCCCGATTGATTGAAATCATTGTGTGTAGGACCTGTTGTAATTGAAA
TCTATCTTAAAACCAAACTTGTAAAACATTCTGATTATCATTTAGAGAGTCTTTTATCTATAGA
TTAAAAATCACTTCATTTTCAGTAAAATGTTGTGGTGTGGAGTTTGAAAGCAAAATAGATCAAT
TTTTGTTTTTCCGTTATCTCATTTTTAATACTCATTTTTTTGGTATAATATAAATGGCAGAAAT
GTTTATAAGACTTATAGTAGGTGAAACTTAAAAATACAGGTGACCACAGAGTCCAGAAACTGAC
AACATATACTTCTTCCTTGATTACTTCTCAGATATGTAAGGGCACAAGTTTATTCAGTGAAAAT
GAGACACACAGATCACCTTGGCAATGTGTTGTAGGTGGATATACAAGGATTGATGAAAATACTG
CTTTAAGTGAAATTGTTGACTGCAGTTTTGCATATCTTGTTGAACTATGAATTGCTAGTGAGGA
ACAGCATGTTCATTGAACATTTGTTGGAATATCATTGGACTATTATGTATATTTGTGTATGTTT
CCAGACCTTATGGCCACCTGAACAATTTTAATTCAGAAAACTGAAGAATAGTCACATATACTAA
ATCTTATTAAATAATGAAAAGGATATATTATACTGTAATGCATCTCTTATATACAGTTTTTCCT
AATTGACCTTATTTTGTTCTGATCATTAAACTTCTACCTGCTTAAGTTGAACTGTA

hide sequence

RefSeq Acc Id:

XR_005359283

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	20,917,631 - 20,946,631 (-)	NCBI

RefSeq Acc Id:

XR_005359284

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	20,925,081 - 20,946,631 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038330336	(Get FASTA)	NCBI Sequence Viewer
	XP_038392073	(Get FASTA)	NCBI Sequence Viewer
	XP_038392074	(Get FASTA)	NCBI Sequence Viewer
	XP_038392075	(Get FASTA)	NCBI Sequence Viewer
	XP_038458819	(Get FASTA)	NCBI Sequence Viewer
	XP_038520796	(Get FASTA)	NCBI Sequence Viewer
	XP_854076	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000020498.3
	ENSCAFP00000039935.1
	ENSCAFP00845001796.1
	ENSCAFP00845001810
	ENSCAFP00845001810.1
	ENSCAFP00845001823.1
	ENSCAFP00845002000.1
	ENSCAFP00845002033.1

RefSeq Acc Id:	XP_854076 ⟸ XM_848983
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3RRF3 (UniProtKB/TrEMBL), A0A8P0SIF8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSGEGGGGGGGGGRRRARVSRLVSFSATHRLHSKSLSNEENLKLFGKCNNPNGHGHNYKVVVTV HGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADVVSTTENVAVYIWENLQKFLP LGVLYKVKVYETDNNIVVYKGE hide sequence

Ensembl Acc Id:

ENSCAFP00000058486 ⟸ ENSCAFT00000080481

Ensembl Acc Id:

ENSCAFP00000039935 ⟸ ENSCAFT00000042885

Ensembl Acc Id:

ENSCAFP00000020498 ⟸ ENSCAFT00000022074

RefSeq Acc Id:	XP_038330336 ⟸ XM_038474408
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038458819 ⟸ XM_038602891
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038520796 ⟸ XM_038664868
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3RRF3 (UniProtKB/TrEMBL), A0A8P0SIF8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038392073 ⟸ XM_038536145
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I3MYK2 (UniProtKB/TrEMBL), A0A8P0NR79 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038392074 ⟸ XM_038536146
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I3MYK2 (UniProtKB/TrEMBL), A0A8P0NR79 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038392075 ⟸ XM_038536147
- Peptide Label:	isoform X1

Promoters

RGD ID:

13683157

Promoter ID:

EPDNEW_C1224

Type:

multiple initiation site

Name:

PTS_1

Description:

6-pyruvoyltetrahydropterin synthase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	20,912,330 - 20,912,390	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000013915	Ensembl
	ENSCAFG00000013963	UniProtKB/TrEMBL
	ENSCAFG00845001320	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000022074.5	UniProtKB/TrEMBL
	ENSCAFT00000042885.4	UniProtKB/TrEMBL
	ENSCAFT00845002269.1	UniProtKB/TrEMBL
	ENSCAFT00845002284	ENTREZGENE
	ENSCAFT00845002284.1	UniProtKB/TrEMBL
	ENSCAFT00845002299.1	UniProtKB/TrEMBL
	ENSCAFT00845002515.1	UniProtKB/TrEMBL
	ENSCAFT00845002555.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.479.10	UniProtKB/TrEMBL
InterPro	6-PTP_synth/QueD	UniProtKB/TrEMBL
	6-PTP_synth/QueD_sf	UniProtKB/TrEMBL
	Carotenoid_Oase	UniProtKB/TrEMBL
	PTPS_Cys_AS	UniProtKB/TrEMBL
	PTPS_His_AS	UniProtKB/TrEMBL
KEGG Report	cfa:611326	UniProtKB/TrEMBL
NCBI Gene	PTS	ENTREZGENE
PANTHER	6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE	UniProtKB/TrEMBL
	BETA,BETA-CAROTENE 9',10'-OXYGENASE	UniProtKB/TrEMBL
	PTHR10543	UniProtKB/TrEMBL
	PTHR12589	UniProtKB/TrEMBL
Pfam	PTPS	UniProtKB/TrEMBL
	RPE65	UniProtKB/TrEMBL
PIRSF	PTP_synth	UniProtKB/TrEMBL
PROSITE	PTPS_1	UniProtKB/TrEMBL
	PTPS_2	UniProtKB/TrEMBL
Superfamily-SCOP	Tetrahydrobiopterin biosynthesis enzymes-like	UniProtKB/TrEMBL
UniProt	A0A8I3MEA1_CANLF	UniProtKB/TrEMBL
	A0A8I3MG13_CANLF	UniProtKB/TrEMBL
	A0A8I3MYK2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3RPU9_CANLF	UniProtKB/TrEMBL
	A0A8I3RRF3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NR79	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SIF8	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:45203	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB