PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6) - Rat Genome Database

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Gene: PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6) Canis lupus familiaris
Analyze
Symbol: PLEKHG6
Name: pleckstrin homology and RhoGEF domain containing G6
RGD ID: 12249149
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); ASSOCIATED WITH genetic disease (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); lymphoproliferative syndrome 2 (ortholog); FOUND IN cell junction (inferred); centrosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family G member 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,654,879 - 38,670,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,654,886 - 38,670,354 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,943,742 - 7,959,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02739,011,002 - 39,026,871 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2739,011,012 - 39,026,487 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,883,535 - 38,899,388 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,925,020 - 38,940,874 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,422,587 - 7,438,302 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLEKHG6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,654,879 - 38,670,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,654,886 - 38,670,354 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,943,742 - 7,959,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02739,011,002 - 39,026,871 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2739,011,012 - 39,026,487 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,883,535 - 38,899,388 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,925,020 - 38,940,874 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,422,587 - 7,438,302 (+)NCBIUU_Cfam_GSD_1.0
PLEKHG6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,310,332 - 6,328,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,310,436 - 6,328,506 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,419,498 - 6,437,672 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,289,863 - 6,307,932 (+)NCBINCBI36Build 36hg18NCBI36
Celera128,036,249 - 8,054,316 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,272,681 - 6,290,919 (+)NCBIHuRef
CHM1_1126,418,827 - 6,436,893 (+)NCBICHM1_1
T2T-CHM13v2.0126,319,720 - 6,337,898 (+)NCBIT2T-CHM13v2.0
Plekhg6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,339,614 - 125,358,578 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,339,623 - 125,357,756 (-)EnsemblGRCm39 Ensembl
GRCm386125,362,651 - 125,381,615 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,362,660 - 125,380,793 (-)EnsemblGRCm38mm10GRCm38
MGSCv376125,312,669 - 125,330,522 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,328,270 - 125,346,123 (-)NCBIMGSCv36mm8
Celera6127,033,915 - 127,051,970 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
Plekhg6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,849,987 - 159,885,730 (-)NCBIGRCr8
mRatBN7.24158,163,443 - 158,182,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,162,969 - 158,182,271 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04157,877,725 - 157,897,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,878,182 - 157,894,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,894,177 - 224,913,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,185,519 - 162,201,845 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4146,899,738 - 146,918,955 (-)NCBICelera
Cytogenetic Map4q42NCBI
Plekhg6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,970,923 - 3,982,154 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,969,459 - 3,982,348 (+)NCBIChiLan1.0ChiLan1.0
PLEKHG6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21011,853,316 - 11,888,327 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11211,850,074 - 11,885,085 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,438,815 - 6,457,356 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,356,211 - 6,373,988 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,356,211 - 6,373,988 (+)Ensemblpanpan1.1panPan2
Plekhg6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,754,083 - 102,770,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,421,531 - 1,438,003 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,421,550 - 1,437,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHG6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,332,066 - 64,350,710 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,331,467 - 64,350,680 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,793,676 - 66,811,294 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHG6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,346,009 - 6,364,280 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,348,244 - 6,364,207 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,871,349 - 1,889,056 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhg6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248603,097,697 - 3,111,159 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLEKHG6
180 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 5
Low 3 4 17 6 6 1 10 10 3
Below cutoff 1 5 6 6 2 8 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038439221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038439222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038439223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038459734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038459736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038513884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038513885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038513886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038576556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038641728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038641729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038641730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_534913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000024139   ⟹   ENSCAFP00000022410
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,654,886 - 38,670,354 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000039538   ⟹   ENSCAFP00000035402
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,654,886 - 38,670,354 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081575   ⟹   ENSCAFP00000062357
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,654,886 - 38,670,354 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845052365   ⟹   ENSCAFP00845041078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2739,011,012 - 39,026,487 (-)Ensembl
RefSeq Acc Id: XM_038439221   ⟹   XP_038295149
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02739,011,002 - 39,026,871 (-)NCBI
RefSeq Acc Id: XM_038439222   ⟹   XP_038295150
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02739,011,002 - 39,026,703 (-)NCBI
RefSeq Acc Id: XM_038439223   ⟹   XP_038295151
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02739,011,002 - 39,026,871 (-)NCBI
RefSeq Acc Id: XM_038459734   ⟹   XP_038315662
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha277,943,742 - 7,959,595 (+)NCBI
RefSeq Acc Id: XM_038459736   ⟹   XP_038315664
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha277,943,742 - 7,959,595 (+)NCBI
RefSeq Acc Id: XM_038513884   ⟹   XP_038369812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12738,883,535 - 38,899,388 (-)NCBI
RefSeq Acc Id: XM_038513885   ⟹   XP_038369813
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12738,883,535 - 38,899,231 (-)NCBI
RefSeq Acc Id: XM_038513886   ⟹   XP_038369814
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12738,883,535 - 38,899,388 (-)NCBI
RefSeq Acc Id: XM_038576556   ⟹   XP_038432484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0277,422,587 - 7,438,302 (+)NCBI
RefSeq Acc Id: XM_038641728   ⟹   XP_038497656
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02738,925,020 - 38,940,874 (-)NCBI
RefSeq Acc Id: XM_038641729   ⟹   XP_038497657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02738,925,020 - 38,940,715 (-)NCBI
RefSeq Acc Id: XM_038641730   ⟹   XP_038497658
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02738,925,020 - 38,940,874 (-)NCBI
RefSeq Acc Id: XM_534913   ⟹   XP_534913
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12738,654,879 - 38,670,553 (-)NCBI
Dog10K_Boxer_Tasha277,943,901 - 7,959,595 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_534913   ⟸   XM_534913
- UniProtKB: A0A8C0TC04 (UniProtKB/TrEMBL),   A0A8P0NMZ4 (UniProtKB/TrEMBL),   A0A8C0PE05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000035402   ⟸   ENSCAFT00000039538
RefSeq Acc Id: ENSCAFP00000022410   ⟸   ENSCAFT00000024139
RefSeq Acc Id: ENSCAFP00000062357   ⟸   ENSCAFT00000081575
RefSeq Acc Id: XP_038369814   ⟸   XM_038513886
RefSeq Acc Id: XP_038369812   ⟸   XM_038513884
RefSeq Acc Id: XP_038369813   ⟸   XM_038513885
RefSeq Acc Id: XP_038497658   ⟸   XM_038641730
RefSeq Acc Id: XP_038497656   ⟸   XM_038641728
RefSeq Acc Id: XP_038497657   ⟸   XM_038641729
RefSeq Acc Id: XP_038295151   ⟸   XM_038439223
- UniProtKB: A0A8I3Q1U7 (UniProtKB/TrEMBL),   A0A8C0PE05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038295149   ⟸   XM_038439221
- UniProtKB: A0A8I3Q1U7 (UniProtKB/TrEMBL),   A0A8C0PE05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038295150   ⟸   XM_038439222
- UniProtKB: A0A8I3Q1U7 (UniProtKB/TrEMBL),   A0A8C0PE05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038315662   ⟸   XM_038459734
- UniProtKB: A0A8C0TC04 (UniProtKB/TrEMBL),   A0A8P0NMZ4 (UniProtKB/TrEMBL),   A0A8C0PE05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038315664   ⟸   XM_038459736
- UniProtKB: A0A8C0TC04 (UniProtKB/TrEMBL),   A0A8P0NMZ4 (UniProtKB/TrEMBL),   A0A8C0PE05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432484   ⟸   XM_038576556
- UniProtKB: A0A8C0PE05 (UniProtKB/TrEMBL),   A0A8I3Q1U7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845041078   ⟸   ENSCAFT00845052365
Protein Domains
DH   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015203 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024207 UniProtKB/TrEMBL
  ENSCAFG00040020777 UniProtKB/TrEMBL
  ENSCAFG00845029568 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000039538.5 UniProtKB/TrEMBL
  ENSCAFT00030044549.1 UniProtKB/TrEMBL
  ENSCAFT00030044586.1 UniProtKB/TrEMBL
  ENSCAFT00030044630.1 UniProtKB/TrEMBL
  ENSCAFT00040038468.1 UniProtKB/TrEMBL
  ENSCAFT00040038501.1 UniProtKB/TrEMBL
  ENSCAFT00040038578.1 UniProtKB/TrEMBL
  ENSCAFT00845052365 ENTREZGENE
  ENSCAFT00845052365.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PLEKHG6 UniProtKB/TrEMBL
NCBI Gene PLEKHG6 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 6 UniProtKB/TrEMBL
  PTHR47671 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
UniProt A0A8C0PE05 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PJ21_CANLF UniProtKB/TrEMBL
  A0A8C0RSM4_CANLF UniProtKB/TrEMBL
  A0A8C0TBF6_CANLF UniProtKB/TrEMBL
  A0A8C0TC04 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TC50_CANLF UniProtKB/TrEMBL
  A0A8I3Q1U7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NMZ4 ENTREZGENE
UniProt Secondary A0A8P0NMZ4 UniProtKB/TrEMBL
VGNC ID VGNC:44681 ENTREZGENE