FIGN (fidgetin, microtubule severing factor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: FIGN (fidgetin, microtubule severing factor) Canis lupus familiaris
Analyze
Symbol: FIGN
Name: fidgetin, microtubule severing factor
RGD ID: 12248657
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); microtubule severing ATPase activity (inferred); INVOLVED IN locomotory behavior (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN nuclear matrix (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fidgetin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1368,914,023 - 9,045,240 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl368,920,224 - 8,922,977 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha369,049,767 - 9,190,855 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0369,038,947 - 9,180,410 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl369,039,164 - 9,180,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1369,048,565 - 9,189,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,106,216 - 9,231,397 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0369,220,027 - 9,345,231 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FIGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1368,914,023 - 9,045,240 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl368,920,224 - 8,922,977 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha369,049,767 - 9,190,855 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0369,038,947 - 9,180,410 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl369,039,164 - 9,180,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1369,048,565 - 9,189,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,106,216 - 9,231,397 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0369,220,027 - 9,345,231 (-)NCBIUU_Cfam_GSD_1.0
FIGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382163,602,611 - 163,736,008 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2163,593,396 - 163,736,012 (-)EnsemblGRCh38hg38GRCh38
GRCh372164,459,121 - 164,592,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362164,172,364 - 164,300,759 (-)NCBINCBI36Build 36hg18NCBI36
Build 342164,291,556 - 164,293,651NCBI
Celera2158,074,075 - 158,202,502 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2156,346,627 - 156,474,914 (-)NCBIHuRef
CHM1_12164,470,008 - 164,598,433 (-)NCBICHM1_1
T2T-CHM13v2.02164,059,859 - 164,193,293 (-)NCBIT2T-CHM13v2.0
Fign
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39263,801,852 - 63,928,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl263,801,851 - 63,928,382 (-)EnsemblGRCm39 Ensembl
GRCm38263,971,508 - 64,098,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl263,971,507 - 64,098,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv37263,815,418 - 63,936,064 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36263,778,670 - 63,898,827 (-)NCBIMGSCv36mm8
Celera265,662,900 - 65,783,578 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map237.19NCBI
Fign
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8369,045,918 - 69,169,148 (-)NCBIGRCr8
mRatBN7.2348,637,510 - 48,760,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl348,642,496 - 48,760,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx351,971,883 - 52,089,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0360,555,393 - 60,673,211 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0358,345,891 - 58,463,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0349,992,250 - 50,120,601 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl349,992,397 - 50,120,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0356,637,401 - 56,764,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4346,006,895 - 46,130,212 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1345,903,265 - 46,026,612 (-)NCBI
Celera348,260,684 - 48,378,383 (-)NCBICelera
Cytogenetic Map3q21NCBI
Fign
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544910,271,014 - 10,393,859 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544910,271,125 - 10,400,631 (+)NCBIChiLan1.0ChiLan1.0
FIGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21366,279,486 - 66,407,932 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B66,289,122 - 66,600,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B50,889,187 - 51,022,435 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B168,259,440 - 168,387,036 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B168,258,315 - 168,385,768 (-)Ensemblpanpan1.1panPan2
Fign
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303126,059,464 - 126,183,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646915,434,127 - 15,553,438 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646915,434,150 - 15,556,167 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FIGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1570,262,091 - 70,394,095 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11570,255,270 - 70,394,095 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21578,089,130 - 78,245,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FIGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11049,035,120 - 49,453,559 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1049,052,032 - 49,178,962 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040150,341,369 - 150,475,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fign
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247321,770,852 - 1,899,842 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247321,770,794 - 1,904,398 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FIGN
1464 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5
Low 5 5 15 6 6 6 6 6 7 8 8 6
Below cutoff 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014110793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038446907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038463313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038520981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038584675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005307702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005307703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005307704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005307705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005318098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005318099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005318100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005318101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005350696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005350697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005350698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005350699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000016718   ⟹   ENSCAFP00000015470
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl368,920,224 - 8,922,977 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026799   ⟹   ENSCAFP00845021104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl369,039,164 - 9,179,120 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026808   ⟹   ENSCAFP00845021111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl369,054,993 - 9,180,469 (-)Ensembl
RefSeq Acc Id: XM_038446907   ⟹   XP_038302835
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0369,054,777 - 9,180,402 (-)NCBI
RefSeq Acc Id: XM_038463313   ⟹   XP_038319241
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha369,065,580 - 9,190,848 (-)NCBI
RefSeq Acc Id: XM_038520981   ⟹   XP_038376909
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1369,064,436 - 9,189,810 (-)NCBI
RefSeq Acc Id: XM_038584675   ⟹   XP_038440603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0369,220,027 - 9,345,231 (-)NCBI
RefSeq Acc Id: XM_038649096   ⟹   XP_038505024
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0369,106,216 - 9,231,397 (-)NCBI
RefSeq Acc Id: XR_005307702
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0369,038,947 - 9,180,408 (-)NCBI
RefSeq Acc Id: XR_005307703
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0369,038,947 - 9,180,408 (-)NCBI
RefSeq Acc Id: XR_005307704
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0369,038,947 - 9,180,410 (-)NCBI
RefSeq Acc Id: XR_005307705
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0369,038,947 - 9,180,408 (-)NCBI
RefSeq Acc Id: XR_005318098
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha369,049,767 - 9,190,853 (-)NCBI
RefSeq Acc Id: XR_005318099
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha369,049,767 - 9,190,853 (-)NCBI
RefSeq Acc Id: XR_005318100
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha369,049,767 - 9,190,855 (-)NCBI
RefSeq Acc Id: XR_005318101
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha369,049,767 - 9,190,853 (-)NCBI
RefSeq Acc Id: XR_005350696
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1369,048,565 - 9,189,815 (-)NCBI
RefSeq Acc Id: XR_005350697
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1369,048,565 - 9,189,815 (-)NCBI
RefSeq Acc Id: XR_005350698
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1369,048,565 - 9,189,817 (-)NCBI
RefSeq Acc Id: XR_005350699
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1369,048,565 - 9,189,815 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000015470   ⟸   ENSCAFT00000016718
RefSeq Acc Id: XP_038376909   ⟸   XM_038520981
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038505024   ⟸   XM_038649096
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038302835   ⟸   XM_038446907
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TKV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038319241   ⟸   XM_038463313
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TKV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440603   ⟸   XM_038584675
- Peptide Label: isoform X3
- UniProtKB: A0A8C0TKV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845021111   ⟸   ENSCAFT00845026808
RefSeq Acc Id: ENSCAFP00845021104   ⟸   ENSCAFT00845026799
Protein Domains
AAA+ ATPase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010526 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016891 UniProtKB/TrEMBL
  ENSCAFG00040023217 UniProtKB/TrEMBL
  ENSCAFG00040023236 UniProtKB/TrEMBL
  ENSCAFG00845014991 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016718.5 UniProtKB/TrEMBL
  ENSCAFT00000072643.2 UniProtKB/TrEMBL
  ENSCAFT00030031211.1 UniProtKB/TrEMBL
  ENSCAFT00040043136.1 UniProtKB/TrEMBL
  ENSCAFT00040043166.1 UniProtKB/TrEMBL
  ENSCAFT00845026799.1 UniProtKB/TrEMBL
  ENSCAFT00845026808.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/TrEMBL
  Fidgetin_ATPase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Vps4_C UniProtKB/TrEMBL
NCBI Gene FIGN ENTREZGENE
PANTHER AAA DOMAIN-CONTAINING UniProtKB/TrEMBL
  FIDGETIN UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  Vps4_C UniProtKB/TrEMBL
PROSITE AAA UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0NTZ6_CANLF UniProtKB/TrEMBL
  A0A8C0TKV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NSJ9_CANLF UniProtKB/TrEMBL
  A0A8I3P479_CANLF UniProtKB/TrEMBL
  A0A8P0NCJ2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:53093 ENTREZGENE