SERPINH1 (serpin family H member 1) - Rat Genome Database

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Gene: SERPINH1 (serpin family H member 1) Canis lupus familiaris
Analyze
Symbol: SERPINH1
Name: serpin family H member 1
RGD ID: 12248603
Description: ENCODES a protein that exhibits collagen binding (inferred); serine-type endopeptidase inhibitor activity (inferred); unfolded protein binding (inferred); INVOLVED IN chondrocyte development involved in endochondral bone morphogenesis (ortholog); collagen biosynthetic process (ortholog); collagen fibril organization (ortholog); ASSOCIATED WITH osteogenesis imperfecta type 10; 3-methylglutaconic aciduria type 7b (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN collagen trimer (inferred); cytoplasm (inferred); endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: serpin H1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,032,761 - 23,041,649 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,032,767 - 23,041,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,798,470 - 22,807,285 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,235,602 - 23,244,497 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,235,605 - 23,244,400 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12123,034,077 - 23,042,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,230,397 - 23,239,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,148,229 - 23,157,093 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:19629171   PMID:22301074   PMID:22847422   PMID:23315765   PMID:26004778   PMID:27129216   PMID:30032202  


Genomics

Comparative Map Data
SERPINH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,032,761 - 23,041,649 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,032,767 - 23,041,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,798,470 - 22,807,285 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,235,602 - 23,244,497 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,235,605 - 23,244,400 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12123,034,077 - 23,042,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,230,397 - 23,239,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,148,229 - 23,157,093 (-)NCBIUU_Cfam_GSD_1.0
SERPINH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,562,253 - 75,572,783 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,562,056 - 75,572,783 (+)EnsemblGRCh38hg38GRCh38
GRCh371175,273,298 - 75,283,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,950,818 - 74,961,494 (+)NCBINCBI36Build 36hg18NCBI36
Build 341174,950,817 - 74,961,492NCBI
Celera1172,580,950 - 72,591,621 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1171,570,181 - 71,580,924 (+)NCBIHuRef
CHM1_11175,156,705 - 75,167,451 (+)NCBICHM1_1
T2T-CHM13v2.01175,491,520 - 75,502,159 (+)NCBIT2T-CHM13v2.0
Serpinh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,994,583 - 99,002,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,994,583 - 99,002,446 (-)EnsemblGRCm39 Ensembl
GRCm38799,345,375 - 99,353,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,345,376 - 99,353,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,493,885 - 106,501,749 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36799,219,459 - 99,227,179 (-)NCBIMGSCv36mm8
Celera799,670,192 - 99,678,104 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.07NCBI
Serpinh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,055,630 - 163,063,177 (-)NCBIGRCr8
mRatBN7.21153,643,500 - 153,650,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,643,510 - 153,650,801 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,639,548 - 161,646,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,819,703 - 168,827,047 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,693,225 - 161,700,569 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,301,010 - 164,308,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,301,010 - 164,308,317 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,503,468 - 170,510,764 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,666,914 - 156,674,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,745,319 - 156,752,617 (-)NCBI
Celera1151,727,297 - 151,734,593 (-)NCBICelera
Cytogenetic Map1q32NCBI
Serpinh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,284,845 - 16,292,963 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541416,284,845 - 16,292,828 (-)NCBIChiLan1.0ChiLan1.0
SERPINH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2976,486,335 - 76,503,355 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11177,528,934 - 77,545,958 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,621,893 - 70,632,570 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11173,922,617 - 73,933,379 (+)NCBIpanpan1.1PanPan1.1panPan2
Serpinh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,742,342 - 62,751,791 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,341,899 - 4,351,524 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,341,944 - 4,351,432 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,783,042 - 9,794,483 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.199,782,939 - 9,794,485 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2910,966,800 - 10,977,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,787,978 - 66,798,930 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,788,240 - 66,799,072 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604359,006,758 - 59,017,494 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,561,471 - 1,570,947 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248171,561,471 - 1,570,425 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SERPINH1
163 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 2 7 10 6
Low 4 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008665   ⟹   ENSCAFP00000008031
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2123,032,767 - 23,041,625 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020139   ⟹   ENSCAFP00845015787
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2123,235,605 - 23,243,700 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020181   ⟹   ENSCAFP00845015819
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2123,235,607 - 23,244,400 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845020225   ⟹   ENSCAFP00845015855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2123,235,624 - 23,244,400 (-)Ensembl
RefSeq Acc Id: NM_001165888   ⟹   NP_001159360
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12123,032,767 - 23,041,625 (-)NCBI
Dog10K_Boxer_Tasha2122,798,470 - 22,807,285 (-)NCBI
ROS_Cfam_1.02123,235,608 - 23,244,473 (-)NCBI
UMICH_Zoey_3.12123,034,077 - 23,042,936 (-)NCBI
UNSW_CanFamBas_1.02123,230,397 - 23,239,216 (-)NCBI
UU_Cfam_GSD_1.02123,148,229 - 23,157,093 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038429479   ⟹   XP_038285407
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02123,235,602 - 23,244,497 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001159360   ⟸   NM_001165888
- Peptide Label: precursor
- UniProtKB: A0A8C0STN6 (UniProtKB/TrEMBL),   A0A8I3N7V2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000008031   ⟸   ENSCAFT00000008665
RefSeq Acc Id: XP_038285407   ⟸   XM_038429479
- Peptide Label: isoform X1
- UniProtKB: A0A8C0STN6 (UniProtKB/TrEMBL),   A0A8I3N7V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845015787   ⟸   ENSCAFT00845020139
RefSeq Acc Id: ENSCAFP00845015855   ⟸   ENSCAFT00845020225
RefSeq Acc Id: ENSCAFP00845015819   ⟸   ENSCAFT00845020181
Protein Domains
SERPIN

Promoters
RGD ID:13687187
Promoter ID:EPDNEW_C5255
Type:initiation region
Name:SERPINH1_1
Description:serpin family H member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12123,041,556 - 23,041,616EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005386 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018761 UniProtKB/TrEMBL
  ENSCAFG00040016632 UniProtKB/TrEMBL
  ENSCAFG00845011365 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008665.5 UniProtKB/TrEMBL
  ENSCAFT00000107089.1 UniProtKB/TrEMBL
  ENSCAFT00000109161.1 UniProtKB/TrEMBL
  ENSCAFT00030034701.1 UniProtKB/TrEMBL
  ENSCAFT00040030745.1 UniProtKB/TrEMBL
  ENSCAFT00040030826.1 UniProtKB/TrEMBL
  ENSCAFT00040030912.1 UniProtKB/TrEMBL
  ENSCAFT00845020139.1 UniProtKB/TrEMBL
  ENSCAFT00845020181 ENTREZGENE
  ENSCAFT00845020181.1 UniProtKB/TrEMBL
  ENSCAFT00845020225 ENTREZGENE
  ENSCAFT00845020225.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Casein_CS UniProtKB/TrEMBL
  Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_H1_serpin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report cfa:485187 UniProtKB/TrEMBL
NCBI Gene SERPINH1 ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  PTHR11461:SF27 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE CASEIN_ALPHA_BETA UniProtKB/TrEMBL
  SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A8C0NVM2_CANLF UniProtKB/TrEMBL
  A0A8C0STN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SVI3_CANLF UniProtKB/TrEMBL
  A0A8C0SYC6_CANLF UniProtKB/TrEMBL
  A0A8I3N7V2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N7Y3_CANLF UniProtKB/TrEMBL
  A0A8I3NIH9_CANLF UniProtKB/TrEMBL
  A0A8P0SAZ3_CANLF UniProtKB/TrEMBL
  A0A8P0TLV9_CANLF UniProtKB/TrEMBL
  A0A8P0TQ37_CANLF UniProtKB/TrEMBL
  C7C419_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:46041 ENTREZGENE