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Gene: ADRB2 (adrenoceptor beta 2) Canis lupus familiaris

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Symbol:

ADRB2

Name:

adrenoceptor beta 2

RGD ID:

12246503

Description:

ENCODES a protein that exhibits B2 bradykinin receptor binding (ortholog); beta2-adrenergic receptor activity (ortholog); G-protein alpha-subunit binding (ortholog); INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); associative learning (ortholog); PARTICIPATES IN adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; epinephrine signaling pathway via adrenergic receptor beta; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH acute kidney failure (ortholog); AIDS Dementia Complex (ortholog); Angina Pectoris (ortholog); FOUND IN axon (ortholog); caveola (ortholog); dendrite (ortholog); INTERACTS WITH (R)-noradrenaline; amosulalol; propranolol

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adrenergic, beta-2-, receptor, surface; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; beta2-adrenergic receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADRB2 (adrenoceptor beta 2)	HGNC	HomoloGene, NCBI
Mus musculus (house mouse):	Adrb2 (adrenergic receptor, beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Adrb2 (adrenoceptor beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adrb2 (adrenoceptor beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADRB2 (adrenoceptor beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adrb2 (adrenoceptor beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADRB2 (adrenoceptor beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADRB2 (adrenoceptor beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adrb2 (adrenoceptor beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	60,048,502 - 60,050,447 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	59,941,517 - 60,050,298 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	59,812,943 - 59,814,888 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	60,537,283 - 60,539,228 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	4	60,317,278 - 60,319,223 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	60,444,286 - 60,446,231 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	60,962,485 - 60,964,430 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

AIDS Dementia Complex (ISO)

Angina Pectoris (ISO)

asthma (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

bronchiolitis (ISO)

cardiomyopathy (ISO)

cholangiocarcinoma (ISO)

chronic obstructive pulmonary disease (ISO)

congestive heart failure (ISO)

Coronary Disease (ISO)

cystic fibrosis (ISO)

dermatitis (ISO)

dilated cardiomyopathy (ISO)

disease of metabolism (ISO)

end stage renal disease (ISO)

Experimental Liver Cirrhosis (ISO)

familial adenomatous polyposis 1 (ISO)

familial hyperlipidemia (ISO)

Fibrosis (ISO)

Graves' disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

human immunodeficiency virus infectious disease (ISO)

Hyperlipoproteinemia Type II (ISO)

hypertension (ISO)

hypokalemia (ISO)

hypothyroidism (ISO)

Insulin Resistance (ISO)

interstitial cystitis (ISO)

kidney disease (ISO)

Left Ventricular Hypertrophy (ISO)

Liver Injury (ISO)

lung disease (ISO)

Metabolic Syndrome (ISO)

myasthenia gravis (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

Myocardial Reperfusion Injury (ISO)

myocarditis (ISO)

Nasal Polyps (ISO)

nervous system disease (ISO)

Neurodevelopmental Disorders (ISO)

obesity (ISO)

open-angle glaucoma (ISO)

Paroxysmal Dyspnea (ISO)

pneumonia (ISO)

polycystic ovary syndrome (ISO)

primary open angle glaucoma (ISO)

Prostatic Neoplasms (ISO)

psoriasis (ISO)

pulmonary edema (ISO)

Reperfusion Injury (ISO)

sciatic neuropathy (ISO)

Sepsis (ISO)

steatotic liver disease (ISO)

Stomach Neoplasms (ISO)

toxic shock syndrome (ISO)

Tremor (ISO)

type 2 diabetes mellitus (ISO)

ulcerative colitis (ISO)

urticaria (ISO)

Ventricular Dysfunction, Left (ISO)

Vestibulocochlear Nerve Injuries (ISO)

viral encephalitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-noradrenaline (EXP)

amosulalol (EXP)

propranolol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating adrenergic receptor signaling pathway (IBA,IEA,ISS)

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA,ISO)

adrenergic receptor signaling pathway (IEA)

AMPA selective glutamate receptor signaling pathway (IEA)

associative learning (ISO)

blood vessel diameter maintenance (IEA)

bone resorption (IEA)

brown fat cell differentiation (IEA)

cellular response to amyloid-beta (IEA)

cellular response to hypoxia (ISO)

diaphragm contraction (ISO)

diet induced thermogenesis (IEA)

estrous cycle (ISO)

excitatory postsynaptic potential (ISO)

female pregnancy (ISO)

G protein-coupled receptor signaling pathway (IEA,ISO)

heat generation (IEA)

liver development (ISO)

liver regeneration (ISO)

negative regulation of angiogenesis (ISO)

negative regulation of G protein-coupled receptor signaling pathway (IEA,ISS)

negative regulation of interleukin-6 production (ISO)

negative regulation of multicellular organism growth (IEA)

negative regulation of ossification (ISO)

negative regulation of smooth muscle contraction (IEA)

negative regulation of tumor necrosis factor production (ISO)

negative regulation of urine volume (ISO)

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure (IBA,IEA)

positive regulation of apoptotic process (ISO)

positive regulation of ATP-dependent activity (ISO)

positive regulation of autophagosome maturation (IEA,ISS)

positive regulation of bone mineralization (IEA)

positive regulation of calcium ion import across plasma membrane (ISO)

positive regulation of cAMP/PKA signal transduction (IEA)

positive regulation of cell population proliferation (ISO)

positive regulation of cold-induced thermogenesis (IEA)

positive regulation of lipophagy (IEA,ISS)

positive regulation of MAPK cascade (IBA,IEA,ISS)

positive regulation of mini excitatory postsynaptic potential (IEA)

positive regulation of potassium ion transport (ISO)

positive regulation of skeletal muscle tissue growth (ISO)

positive regulation of sodium ion transport (ISO)

positive regulation of the force of heart contraction by epinephrine (ISO)

positive regulation of transcription by RNA polymerase II (IEA)

presynaptic modulation of chemical synaptic transmission (ISO)

receptor-mediated endocytosis (IEA,ISS)

regulation of calcium ion transport (ISO)

regulation of smooth muscle contraction (IEA)

regulation of sodium ion transport (IEA)

regulation of systemic arterial blood pressure by norepinephrine-epinephrine (IEA)

regulation of vein smooth muscle contraction (ISO)

response to catecholamine (ISO)

response to cold (IEA)

response to dexamethasone (ISO)

response to estrogen (ISO)

response to hypoxia (ISO)

response to monoamine (ISO)

response to progesterone (ISO)

response to testosterone (ISO)

signal transduction (IEA)

smooth muscle contraction (IEA)

synaptic transmission, glutamatergic (ISO)

transcription by RNA polymerase II (IEA)

vasodilation (ISO)

Cellular Component

apical plasma membrane (IEA)

axon (ISO)

caveola (ISO)

ciliary basal body (IEA)

cilium (IEA)

dendrite (ISO)

dendritic spine (ISO)

early endosome (IEA)

endosome (IEA,ISO)

glutamatergic synapse (ISO)

Golgi apparatus (IEA)

intercellular bridge (IEA)

membrane (IEA)

microtubule cytoskeleton (IEA)

mitotic spindle (IEA)

neuronal cell body membrane (ISO)

neuronal dense core vesicle (IEA)

nucleus (IEA)

plasma membrane (IBA,IEA)

postsynaptic membrane (ISO)

receptor complex (IEA,ISS)

sarcolemma (ISO)

Schaffer collateral - CA1 synapse (ISO)

Molecular Function

adenylate cyclase binding (IEA)

adrenergic receptor activity (IEA)

amyloid-beta binding (IEA)

B2 bradykinin receptor binding (ISO)

beta2-adrenergic receptor activity (IBA,IEA,ISO,ISS)

enzyme binding (IEA)

G protein-coupled receptor activity (IEA)

G-protein alpha-subunit binding (ISO)

identical protein binding (IEA)

ionotropic glutamate receptor binding (ISO)

norepinephrine binding (IBA,IEA,ISS)

potassium channel regulator activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA,ISS)

protein phosphatase 2A binding (ISO)

protein-containing complex binding (IEA,ISO)

receptor-receptor interaction (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway (ISO)

epinephrine signaling pathway via adrenergic receptor beta (ISO)

G protein mediated signaling pathway via Galphai family (ISO)

G protein mediated signaling pathway via Galphas family (ISO)

References

Additional References at PubMed

PMID:8880434	PMID:9220370	PMID:11214319	PMID:19237665	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ADRB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	60,048,502 - 60,050,447 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	59,941,517 - 60,050,298 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	59,812,943 - 59,814,888 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	60,537,283 - 60,539,228 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	4	60,317,278 - 60,319,223 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	60,444,286 - 60,446,231 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	60,962,485 - 60,964,430 (-)	NCBI		UU_Cfam_GSD_1.0

ADRB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	148,826,611 - 148,828,623 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	148,826,611 - 148,828,623 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	148,206,174 - 148,208,186 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	148,186,349 - 148,188,381 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	148,186,368 - 148,188,379	NCBI
Celera	5	144,288,206 - 144,290,248 (+)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	143,352,751 - 143,354,793 (+)	NCBI		HuRef
CHM1_1	5	147,638,640 - 147,640,684 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	149,361,444 - 149,363,456 (+)	NCBI		T2T-CHM13v2.0

Adrb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	62,310,784 - 62,313,052 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	62,310,887 - 62,313,030 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	62,177,713 - 62,179,981 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	62,177,816 - 62,179,959 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	62,337,470 - 62,339,613 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	62,303,185 - 62,305,328 (-)	NCBI		MGSCv36	mm8
Celera	18	63,462,804 - 63,464,949 (-)	NCBI		Celera
Cytogenetic Map	18	E1	NCBI
cM Map	18	35.1	NCBI

Adrb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	57,912,760 - 57,914,802 (-)	NCBI		GRCr8
mRatBN7.2	18	55,642,459 - 55,644,501 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	55,502,903 - 55,644,512 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	57,735,062 - 57,737,132 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	58,450,067 - 58,452,145 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	56,266,287 - 56,268,329 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	57,513,792 - 57,515,834 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	57,513,793 - 57,515,834 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	56,739,990 - 56,742,032 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	58,174,958 - 58,177,000 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	58,247,190 - 58,249,232 (-)	NCBI
Celera	18	53,789,848 - 53,791,890 (-)	NCBI		Celera
RH 3.4 Map	18	542.9	RGD
Cytogenetic Map	18	q12.1	NCBI

Adrb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	5,515,697 - 5,516,980 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	5,515,157 - 5,517,198 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADRB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	144,063,792 - 144,193,838 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	142,203,567 - 142,333,375 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	144,259,756 - 144,398,421 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	150,267,321 - 150,269,339 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	150,267,554 - 150,315,892 (+)	Ensembl	panpan1.1		panPan2

Adrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	144,411,444 - 144,414,154 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	5,985,960 - 5,987,210 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	5,985,407 - 5,987,453 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADRB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	150,033,579 - 150,040,731 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	150,032,649 - 150,035,591 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ADRB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	51,445,920 - 51,447,942 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	51,446,154 - 51,447,401 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	26,307,284 - 26,309,305 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adrb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	8,211,984 - 8,213,240 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	8,211,723 - 8,215,962 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ADRB2
9 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY011309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U73206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X94608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000029135 ⟹ ENSCAFP00000027094

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	4	59,941,517 - 60,050,298 (-)	Ensembl

RefSeq Acc Id:

NM_001003234 ⟹ NP_001003234

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	4	60,048,502 - 60,050,447 (-)	NCBI
Dog10K_Boxer_Tasha	4	59,812,943 - 59,814,888 (-)	NCBI
ROS_Cfam_1.0	4	60,537,283 - 60,539,228 (-)	NCBI
UMICH_Zoey_3.1	4	60,317,278 - 60,319,223 (-)	NCBI
UNSW_CanFamBas_1.0	4	60,444,286 - 60,446,231 (-)	NCBI
UU_Cfam_GSD_1.0	4	60,962,485 - 60,964,430 (-)	NCBI

Sequence:

show sequence

CCGGGGCGCAGGCTGTGGGGGCCGCGCGGGCGAGCGCAGAGCACCCCGCGAGCTGGATGCGGCT
TCCCGGCGCCCGCTCGCTGCCCGCGGCGCCGCCCCCGAGGTCCGCCCGCTGAGGCGCCCGTGCG
CTCACCTGCCGGCCCGCGCGCCATGGGCCAGCCCGCGAACCGCAGCGTCTTCTTGCTGGCGCCC
AACGGGAGCCACGCGCCGGACCAGGGAGACTCGCAGGAGCGGAGCGAGGCGTGGGTGGTGGGCA
TGGGCATCGTCATGTCGCTCATCGTCCTGGCCATCGTGTTCGGGAACGTGCTGGTCATCACGGC
CATCGCCAGGTTCGAGCGTCTGCAGACGGTCACCAACTACTTCATCACCTCCCTGGCCTGTGCT
GACCTGGTCATGGGCCTGGCGGTGGTGCCCTTTGGGGCCAGCCACATCCTCATGAAAATGTGGA
CCTTCGGCAACTTCTGGTGTGAGTTTTGGACTTCCATTGACGTATTGTGCGTCACGGCCAGCAT
CGAGACCCTGTGCGTGATCGCGGTGGACCGCTACTTTGCCATCACCTCGCCCTTCAAGTACCAG
AGCCTGCTGACCAAGAATAAGGCCCGGGTGGTCATTCTGATGGTGTGGATCGTGTCCGGCCTCA
CCTCCTTCTTGCCCATCCAGATGCACTGGTACCGGGCCACCCACCAGGAAGCCATCAACTGCTA
CGCCAAGGAGACGTGCTGTGACTTCTTCACGAACCAAGCCTATGCCATTGCCTCCTCCATCGTG
TCCTTCTACCTACCCCTGGTGGTCATGGTCTTCGTCTACTCCAGGGTCTTCCAGGTGGCCCAGA
GGCAGCTCCAGAAGATCGACAGATCGGAGGGCCGCTTCCATGCCCAAAACCTCAGCCAAGTGGA
GCAGGATGGGCGGAGCGGGCACGGACATCGGAGGTCCTCCAAGTTCTGCTTGAAGGAACACAAG
GCCCTCAAAACTCTGGGCATCATCATGGGCACTTTCACCCTGTGCTGGCTGCCCTTCTTCATCG
TCAACATAGTGCATGTGATCCAGGATAACCTCATCCCTAAGGAAGTTTACATCCTCCTAAACTG
GGTGGGCTACGTCAACTCTGCTTTCAATCCCCTTATCTACTGCCGGAGCCCTGACTTCAGGATT
GCCTTCCAGGAGCTTCTGTGCCTGCGCAGGTCTTCCCTGAAGGCCTATGGGAATGGCTACTCCA
ACAACAGTAACAGCAGAAGCGACTATGCTGGGGAGCACAGTGGATGTCACCTGGGGCAGGAGAA
AGACAGCGAACTGCTGTGTGAGGACCCCCCAGGCACGGAAGACCGTCAAGGTACTGTGCCTAGC
GATAGCGTTGATTCGCAGGGGAGGAATTGTAGTACAAACGACTCACTGCTGTAATGCAGCTTTT
CTACTTTTTATGAACCCCCTCCCCGCAACGAAACACTATACAGACTATTTAACTTGAGTGTAAT
AAATTTAGAATAAAATTGTATAGAGATGTGCAGGAGGAGGGACGGCCTTCTGCCTTTTTTTTTT
TATTTTTTTAGGCTGTAAAAAAAAGAGAAAGCATATTCGAGTGATTGTTTGTTGTACAGTTCAG
TTCCTTTTTTGCATGGAACGTGTAAGTTTGTGTCTGAAGGGCTTTGGTCCCAGAGGACCTGGGG
CTGCTATGTTTTGATGACTTTTCCGTGGATCTACCTCATTGATCAAGTATTAGGGGTAATATAT
ATTGCTGCTGGTCATCTGTATGTGAAGGAGTCTTTTCTTCCTGCACCCTTGCACTGGAGGATCT
TGAGTATCTCGGACCTTTCAGCTGTGAACACGGACTCTGCTGGCCCCTCTTATTTGCTCAAACA
GGGTGTTGTTGTAGGCAGGGATTTGAGGGGCAGCTTCAGTTGTGTTCCTGAGCAAAGTCTAAAG
TTTACAGTAAATAAATTGTTTGACCATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001003234	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB93647	(Get FASTA)	NCBI Sequence Viewer
	AAG35469	(Get FASTA)	NCBI Sequence Viewer
	CAA64316	(Get FASTA)	NCBI Sequence Viewer
	P54833	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001003234 ⟸ NM_001003234

- UniProtKB:

P54833 (UniProtKB/Swiss-Prot), A0A8C0R6J8 (UniProtKB/TrEMBL), A0A8C0QF26 (UniProtKB/TrEMBL), A0A8P0TUG8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGQPANRSVFLLAPNGSHAPDQGDSQERSEAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERL
QTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIA
VDRYFAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAKETCCD
FFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQLQKIDRSEGRFHAQNLSQVEQDGRSGH
GHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSA
FNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSNNSNSRSDYAGEHSGCHLGQEKDSELLCE
DPPGTEDRQGTVPSDSVDSQGRNCSTNDSLL

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Ensembl Acc Id:

ENSCAFP00000027094 ⟸ ENSCAFT00000029135

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000018339	Ensembl
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
InterPro	ADR_fam	UniProtKB/Swiss-Prot
	ADRB2_rcpt	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
KEGG Report	cfa:403910	UniProtKB/Swiss-Prot
NCBI Gene	ADRB2	ENTREZGENE
PANTHER	ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot
	PTHR24248:SF21	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PRINTS	ADRENERGICR	UniProtKB/Swiss-Prot
	ADRENRGCB2AR	UniProtKB/Swiss-Prot
	GPCRRHODOPSN	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	A0A8C0QF26	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0R6J8	ENTREZGENE
	A0A8P0SMA4_CANLF	UniProtKB/TrEMBL
	A0A8P0TUG8	ENTREZGENE
	ADRB2_CANLF	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9BFW3_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:111873	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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