MTFR2 (mitochondrial fission regulator 2) - Rat Genome Database

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Gene: MTFR2 (mitochondrial fission regulator 2) Canis lupus familiaris
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Symbol: MTFR2
Name: mitochondrial fission regulator 2
RGD ID: 12245643
Description: INVOLVED IN aerobic respiration (inferred); mitochondrial fission (inferred); mitochondrion organization (inferred); ASSOCIATED WITH Familial Behcet-Like Autoinflammatory Syndrome (ortholog); genetic disease (ortholog); immunodeficiency 27A (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FAM54A; family with sequence similarity 54, member A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1128,830,818 - 28,844,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl128,830,867 - 28,844,710 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha129,708,976 - 29,723,038 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0128,986,198 - 29,000,267 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,984,794 - 29,000,115 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1128,872,409 - 28,886,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0128,755,384 - 28,769,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0129,056,087 - 29,070,152 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MTFR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1128,830,818 - 28,844,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl128,830,867 - 28,844,710 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha129,708,976 - 29,723,038 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0128,986,198 - 29,000,267 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,984,794 - 29,000,115 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1128,872,409 - 28,886,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0128,755,384 - 28,769,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0129,056,087 - 29,070,152 (-)NCBIUU_Cfam_GSD_1.0
MTFR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386136,231,034 - 136,250,311 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6136,231,024 - 136,250,335 (-)EnsemblGRCh38hg38GRCh38
GRCh376136,552,172 - 136,571,449 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366136,593,861 - 136,613,142 (-)NCBINCBI36Build 36hg18NCBI36
Build 346136,593,860 - 136,613,142NCBI
Celera6137,292,609 - 137,311,889 (-)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6134,116,804 - 134,136,084 (-)NCBIHuRef
CHM1_16136,814,686 - 136,833,971 (-)NCBICHM1_1
T2T-CHM13v2.06137,419,143 - 137,438,419 (-)NCBIT2T-CHM13v2.0
Mtfr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391020,223,491 - 20,237,415 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1020,223,516 - 20,237,050 (+)EnsemblGRCm39 Ensembl
GRCm381020,344,653 - 20,361,669 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1020,347,770 - 20,361,304 (+)EnsemblGRCm38mm10GRCm38
MGSCv371020,067,625 - 20,081,475 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361020,037,241 - 20,050,735 (+)NCBIMGSCv36mm8
Celera1020,236,666 - 20,250,342 (+)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.75NCBI
Mtfr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,942,814 - 16,958,218 (+)NCBIGRCr8
mRatBN7.2115,123,232 - 15,138,632 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl115,070,894 - 15,148,832 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx114,877,372 - 14,892,479 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,879,304 - 20,894,408 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0115,103,132 - 15,118,478 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,834,779 - 15,850,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,782,477 - 15,860,624 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0117,379,823 - 17,394,566 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera113,553,856 - 13,569,459 (+)NCBICelera
Cytogenetic Map1p12NCBI
Mtfr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955439646,432 - 663,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955439643,289 - 662,921 (+)NCBIChiLan1.0ChiLan1.0
MTFR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25156,201,929 - 156,226,277 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16154,100,726 - 154,124,456 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06133,995,679 - 134,014,947 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16138,085,517 - 138,104,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6138,084,908 - 138,104,740 (-)Ensemblpanpan1.1panPan2
Mtfr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946123,881,482 - 123,893,809 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365603,660,705 - 3,671,917 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365603,656,639 - 3,670,923 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTFR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl127,908,824 - 28,015,101 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1127,906,162 - 27,998,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2131,398,310 - 31,486,257 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTFR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11337,173,430 - 37,192,734 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1337,174,438 - 37,192,790 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660409,361,104 - 9,383,691 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtfr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248861,434,253 - 1,444,462 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248861,431,171 - 1,446,007 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MTFR2
125 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 8
Low 3 2 22 6 6 6 6 11 10 6
Below cutoff 3 6 1

Sequence


RefSeq Acc Id: ENSCAFT00000000380   ⟹   ENSCAFP00000000345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl128,830,867 - 28,844,710 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845009963   ⟹   ENSCAFP00845007772
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl128,984,794 - 29,000,115 (-)Ensembl
RefSeq Acc Id: XM_014112245   ⟹   XP_013967720
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1128,830,818 - 28,844,875 (-)NCBI
Dog10K_Boxer_Tasha129,708,976 - 29,723,038 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038465499   ⟹   XP_038321427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1128,872,409 - 28,886,470 (-)NCBI
RefSeq Acc Id: XM_038526114   ⟹   XP_038382042
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0129,056,087 - 29,070,152 (-)NCBI
RefSeq Acc Id: XM_038590406   ⟹   XP_038446334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0128,755,384 - 28,769,446 (-)NCBI
RefSeq Acc Id: XM_038654230   ⟹   XP_038510158
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0128,986,198 - 29,000,267 (-)NCBI
RefSeq Acc Id: XP_013967720   ⟸   XM_014112245
- UniProtKB: A0A8C0LD22 (UniProtKB/TrEMBL),   A0A8C0MAX2 (UniProtKB/TrEMBL),   A0A8I3RU86 (UniProtKB/TrEMBL),   A0A8P0N3I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000345   ⟸   ENSCAFT00000000380
RefSeq Acc Id: XP_038321427   ⟸   XM_038465499
RefSeq Acc Id: XP_038446334   ⟸   XM_038590406
RefSeq Acc Id: XP_038510158   ⟸   XM_038654230
- UniProtKB: A0A8C0LD22 (UniProtKB/TrEMBL),   A0A8C0MAX2 (UniProtKB/TrEMBL),   A0A8I3RU86 (UniProtKB/TrEMBL),   A0A8P0N3I1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038382042   ⟸   XM_038526114
- UniProtKB: A0A8C0LD22 (UniProtKB/TrEMBL),   A0A8C0MAX2 (UniProtKB/TrEMBL),   A0A8I3RU86 (UniProtKB/TrEMBL),   A0A8P0N3I1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007772   ⟸   ENSCAFT00845009963


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000244 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003582 UniProtKB/TrEMBL
  ENSCAFG00040001303 UniProtKB/TrEMBL
  ENSCAFG00845005614 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000380.7 UniProtKB/TrEMBL
  ENSCAFT00030006687.1 UniProtKB/TrEMBL
  ENSCAFT00040002448.1 UniProtKB/TrEMBL
  ENSCAFT00845009963 ENTREZGENE
  ENSCAFT00845009963.1 UniProtKB/TrEMBL
InterPro Mtfr1 UniProtKB/TrEMBL
KEGG Report cfa:483997 UniProtKB/TrEMBL
NCBI Gene MTFR2 ENTREZGENE
PANTHER MITOCHONDRIAL FISSION REGULATOR 2 UniProtKB/TrEMBL
  PTHR14215 UniProtKB/TrEMBL
Pfam Mito_fiss_reg UniProtKB/TrEMBL
UniProt A0A8C0LD22 ENTREZGENE
  A0A8C0MAX2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RU86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N3I1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43470 ENTREZGENE