PRKN (parkin RBR E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: PRKN (parkin RBR E3 ubiquitin protein ligase) Canis lupus familiaris
Analyze
Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
RGD ID: 12245153
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); cellular response to hydrogen sulfide (ortholog); cellular response to L-glutamate (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; Parkinson's disease pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN axon (ortholog); dopaminergic synapse (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase parkin; PARK2; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson protein 2, E3 ubiquitin protein ligase (parkin)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,886,887 - 51,201,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,889,005 - 51,201,764 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,729,328 - 52,042,064 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0150,071,882 - 51,381,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl150,071,597 - 51,381,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,954,154 - 51,268,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,824,568 - 51,126,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0150,440,798 - 51,751,574 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IEA,ISO)
aggresome assembly  (IEA)
autophagy  (IEA)
cellular response to hydrogen sulfide  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to L-glutamine  (ISO)
cellular response to manganese ion  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to toxic substance  (IEA)
dopamine metabolic process  (IEA,ISO)
dopamine uptake involved in synaptic transmission  (IEA,ISO)
free ubiquitin chain polymerization  (IEA)
learning  (IEA,ISO)
locomotory behavior  (IEA,ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrion localization  (ISO)
mitochondrion to lysosome vesicle-mediated transport  (IEA)
mitophagy  (IEA,ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation by host of viral genome replication  (IEA)
negative regulation of actin filament bundle assembly  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA)
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (IEA)
negative regulation of excitatory postsynaptic potential  (ISO)
negative regulation of exosomal secretion  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of insulin secretion  (IEA,ISO)
negative regulation of intralumenal vesicle formation  (IEA)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA)
negative regulation of protein phosphorylation  (IEA)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (IEA)
negative regulation of release of cytochrome c from mitochondria  (IEA)
negative regulation of spontaneous neurotransmitter secretion  (IEA)
negative regulation of synaptic transmission, glutamatergic  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
norepinephrine metabolic process  (IEA,ISO)
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of dendrite extension  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of metabolic process  (IEA)
positive regulation of mitochondrial fusion  (IEA)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of mitophagy  (IEA,ISO)
positive regulation of mitophagy in response to mitochondrial depolarization  (IEA)
positive regulation of neurotransmitter uptake  (IEA)
positive regulation of proteasomal protein catabolic process  (IEA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein linear polyubiquitination  (IEA)
positive regulation of protein localization to membrane  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
proteasomal protein catabolic process  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein autoubiquitination  (IEA)
protein catabolic process  (IEA)
protein destabilization  (IEA)
protein K11-linked ubiquitination  (IEA)
protein K48-linked ubiquitination  (IEA)
protein K6-linked ubiquitination  (IEA)
protein K63-linked ubiquitination  (IEA)
protein localization to mitochondrion  (IEA)
protein metabolic process  (IEA,ISO)
protein monoubiquitination  (IEA)
protein polyubiquitination  (IEA)
protein stabilization  (IEA)
protein ubiquitination  (IEA)
regulation of apoptotic process  (IEA)
regulation of autophagy  (IEA)
regulation of cellular response to oxidative stress  (IEA)
regulation of dopamine metabolic process  (IEA)
regulation of mitochondrial membrane potential  (IEA)
regulation of mitochondrion organization  (IEA)
regulation of neurotransmitter secretion  (IEA,ISO)
regulation of postsynaptic membrane neurotransmitter receptor levels  (ISO)
regulation of protein stability  (IEA)
regulation of protein ubiquitination  (IEA)
regulation of reactive oxygen species metabolic process  (IEA)
regulation of synaptic vesicle endocytosis  (IEA)
regulation protein catabolic process at presynapse  (IEA)
response to corticosterone  (ISO)
response to curcumin  (ISO)
response to endoplasmic reticulum stress  (IEA,ISO)
response to muscle activity  (ISO)
response to unfolded protein  (ISO)
response to xenobiotic stimulus  (ISO)
startle response  (IEA,ISO)
synaptic transmission, dopaminergic  (IEA,ISO)
synaptic transmission, glutamatergic  (IEA,ISO)
ubiquitin-dependent protein catabolic process  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRKN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,886,887 - 51,201,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,889,005 - 51,201,764 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,729,328 - 52,042,064 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0150,071,882 - 51,381,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl150,071,597 - 51,381,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,954,154 - 51,268,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,824,568 - 51,126,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0150,440,798 - 51,751,574 (-)NCBIUU_Cfam_GSD_1.0
PRKN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386161,347,417 - 162,727,766 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6161,347,417 - 162,727,775 (-)EnsemblGRCh38hg38GRCh38
GRCh376161,768,449 - 163,148,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,689,661 - 163,068,793 (-)NCBINCBI36Build 36hg18NCBI36
Build 346161,740,081 - 163,119,211NCBI
Celera6162,497,923 - 163,878,436 (-)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6159,224,034 - 160,600,983 (-)NCBIHuRef
CHM1_16162,031,091 - 163,411,071 (-)NCBICHM1_1
T2T-CHM13v2.06162,705,911 - 164,090,895 (-)NCBIT2T-CHM13v2.0
Prkn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391711,059,227 - 12,282,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1711,059,271 - 12,282,248 (+)EnsemblGRCm39 Ensembl
GRCm381710,840,359 - 12,063,370 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1710,840,384 - 12,063,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv371711,033,250 - 12,256,227 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361710,683,742 - 11,906,719 (+)NCBIMGSCv36mm8
Celera1710,880,667 - 12,092,859 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map177.8NCBI
Prkn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8151,236,410 - 52,430,242 (-)NCBIGRCr8
mRatBN7.2148,688,651 - 49,882,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,690,556 - 49,882,555 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,387,875 - 50,601,445 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,372,640 - 56,585,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,463,372 - 50,676,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,880,015 - 50,069,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0149,684,308 - 50,875,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,151,265 - 44,374,470 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1143,154,209 - 44,377,415 (-)NCBI
Celera144,478,407 - 45,666,902 (-)NCBICelera
Cytogenetic Map1q11NCBI
Prkn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543918,664,379 - 19,951,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543918,664,230 - 19,953,358 (+)NCBIChiLan1.0ChiLan1.0
PRKN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25181,523,208 - 182,914,092 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16179,428,720 - 180,815,536 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06159,293,016 - 160,679,106 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16164,498,420 - 165,678,904 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6164,314,990 - 165,678,770 (-)Ensemblpanpan1.1panPan2
Prkn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,866,545 - 145,855,394 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648912,120,678 - 13,327,872 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648912,118,538 - 12,913,664 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15,465,312 - 6,730,872 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115,698,508 - 6,731,132 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.217,649,954 - 8,260,243 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.217,197,051 - 7,562,040 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11388,856,056 - 90,329,379 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604061,183,625 - 62,136,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624855430,260 - 1,989,747 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624855430,148 - 1,992,121 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRKN
15093 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 3 5 17 1 4 1 6 6 12 8 10 6
Below cutoff 2 5 5 2 5

Sequence


RefSeq Acc Id: ENSCAFT00000001196   ⟹   ENSCAFP00000001095
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl150,072,818 - 51,201,764 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000047997   ⟹   ENSCAFP00000038072
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl149,889,005 - 51,201,764 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062377   ⟹   ENSCAFP00000058573
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl149,889,005 - 51,201,764 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000069293   ⟹   ENSCAFP00000056877
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl150,767,084 - 50,856,727 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000084755   ⟹   ENSCAFP00000045233
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl149,889,005 - 50,991,041 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000087129   ⟹   ENSCAFP00000050441
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl149,889,005 - 51,201,764 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000089557   ⟹   ENSCAFP00000065648
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl150,767,084 - 50,992,167 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000091486   ⟹   ENSCAFP00000064622
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl150,767,084 - 50,937,549 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093532   ⟹   ENSCAFP00000048357
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl150,767,084 - 50,993,359 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004490   ⟹   ENSCAFP00845003590
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl150,071,597 - 51,381,376 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004497   ⟹   ENSCAFP00845003596
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl150,071,597 - 51,381,376 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004502   ⟹   ENSCAFP00845003600
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl150,071,597 - 51,381,376 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004510   ⟹   ENSCAFP00845003605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl150,257,208 - 51,381,376 (-)Ensembl
RefSeq Acc Id: XM_038465834   ⟹   XP_038321762
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1149,954,154 - 51,268,026 (-)NCBI
RefSeq Acc Id: XM_038526511   ⟹   XP_038382439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0150,440,798 - 51,751,574 (-)NCBI
RefSeq Acc Id: XM_038590807   ⟹   XP_038446735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0149,824,568 - 51,126,809 (-)NCBI
RefSeq Acc Id: XM_038654595   ⟹   XP_038510523
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0150,071,882 - 51,381,593 (-)NCBI
RefSeq Acc Id: XM_850059   ⟹   XP_855152
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1149,886,887 - 51,201,930 (-)NCBI
Dog10K_Boxer_Tasha150,729,328 - 52,042,064 (-)NCBI
Sequence:
RefSeq Acc Id: XP_855152   ⟸   XM_850059
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PPD2 (UniProtKB/TrEMBL),   A0A8I3MGN8 (UniProtKB/TrEMBL),   A0A8C0N0F1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001095   ⟸   ENSCAFT00000001196
RefSeq Acc Id: ENSCAFP00000056877   ⟸   ENSCAFT00000069293
RefSeq Acc Id: ENSCAFP00000045233   ⟸   ENSCAFT00000084755
RefSeq Acc Id: ENSCAFP00000050441   ⟸   ENSCAFT00000087129
RefSeq Acc Id: ENSCAFP00000048357   ⟸   ENSCAFT00000093532
RefSeq Acc Id: ENSCAFP00000064622   ⟸   ENSCAFT00000091486
RefSeq Acc Id: ENSCAFP00000058573   ⟸   ENSCAFT00000062377
RefSeq Acc Id: ENSCAFP00000038072   ⟸   ENSCAFT00000047997
RefSeq Acc Id: ENSCAFP00000065648   ⟸   ENSCAFT00000089557
RefSeq Acc Id: XP_038321762   ⟸   XM_038465834
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038446735   ⟸   XM_038590807
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038510523   ⟸   XM_038654595
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PPD2 (UniProtKB/TrEMBL),   A0A8I3MGN8 (UniProtKB/TrEMBL),   A0A8C0N0F1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038382439   ⟸   XM_038526511
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N0F1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003605   ⟸   ENSCAFT00845004510
RefSeq Acc Id: ENSCAFP00845003596   ⟸   ENSCAFT00845004497
RefSeq Acc Id: ENSCAFP00845003600   ⟸   ENSCAFT00845004502
RefSeq Acc Id: ENSCAFP00845003590   ⟸   ENSCAFT00845004490
Protein Domains
RING-type   Ubiquitin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000769 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010954 UniProtKB/TrEMBL
  ENSCAFG00040000852 UniProtKB/TrEMBL
  ENSCAFG00845002459 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001196.5 UniProtKB/TrEMBL
  ENSCAFT00000047997.3 UniProtKB/TrEMBL
  ENSCAFT00000062377.2 UniProtKB/TrEMBL
  ENSCAFT00000087129.2 UniProtKB/TrEMBL
  ENSCAFT00030020991.1 UniProtKB/TrEMBL
  ENSCAFT00030021195.1 UniProtKB/TrEMBL
  ENSCAFT00040001759.1 UniProtKB/TrEMBL
  ENSCAFT00040001795.1 UniProtKB/TrEMBL
  ENSCAFT00040001802.1 UniProtKB/TrEMBL
  ENSCAFT00040001809.1 UniProtKB/TrEMBL
  ENSCAFT00845004490 ENTREZGENE
  ENSCAFT00845004490.1 UniProtKB/TrEMBL
  ENSCAFT00845004497.1 UniProtKB/TrEMBL
  ENSCAFT00845004502.1 UniProtKB/TrEMBL
  ENSCAFT00845004510.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1750 UniProtKB/TrEMBL
  2.20.25.20 UniProtKB/TrEMBL
InterPro BRcat_RBR_parkin UniProtKB/TrEMBL
  E3_UB_ligase_RBR UniProtKB/TrEMBL
  IBR_dom UniProtKB/TrEMBL
  Parkin UniProtKB/TrEMBL
  Parkin_Znf-RING UniProtKB/TrEMBL
  Rcat_RBR_parkin UniProtKB/TrEMBL
  RING-HC_RBR_parkin UniProtKB/TrEMBL
  TRIAD_supradom UniProtKB/TrEMBL
  Ubiquilin UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Znf-RING_14 UniProtKB/TrEMBL
KEGG Report cfa:612316 UniProtKB/TrEMBL
NCBI Gene PARK2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE PARKIN UniProtKB/TrEMBL
  RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING UniProtKB/TrEMBL
  UBIQUILIN UniProtKB/TrEMBL
  UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
  zf-RING_12 UniProtKB/TrEMBL
  zf-RING_14 UniProtKB/TrEMBL
PIRSF Parkin UniProtKB/TrEMBL
PRINTS PARKIN UniProtKB/TrEMBL
PROSITE TRIAD UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
SMART IBR UniProtKB/TrEMBL
  UBQ UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C0N0F1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PMZ8_CANLF UniProtKB/TrEMBL
  A0A8C0PPD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PPG7_CANLF UniProtKB/TrEMBL
  A0A8C0RUY3_CANLF UniProtKB/TrEMBL
  A0A8I3MGN8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3ML98_CANLF UniProtKB/TrEMBL
  A0A8I3MPY0_CANLF UniProtKB/TrEMBL
  A0A8I3MTH5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:82293 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-24 PRKN  parkin RBR E3 ubiquitin protein ligase  PARK2    Symbol and/or name change 5135510 APPROVED