PARP1 (poly(ADP-ribose) polymerase 1) - Rat Genome Database

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Gene: PARP1 (poly(ADP-ribose) polymerase 1) Canis lupus familiaris
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Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
RGD ID: 12243761
Description: ENCODES a protein that exhibits chromatin binding (ortholog); enzyme binding (ortholog); estrogen receptor binding (ortholog); INVOLVED IN apoptotic process (ortholog); ATP generation from poly-ADP-D-ribose (ortholog); base-excision repair (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); nuclear body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: poly (ADP-ribose) polymerase family, member 1; poly [ADP-ribose] polymerase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,503,072 - 38,542,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,503,067 - 38,542,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,984,470 - 38,024,231 (+)NCBI
ROS_Cfam_1.0738,336,543 - 38,376,496 (+)NCBI
UMICH_Zoey_3.1738,175,521 - 38,215,272 (+)NCBI
UNSW_CanFamBas_1.0738,182,459 - 38,222,219 (+)NCBI
UU_Cfam_GSD_1.0738,453,305 - 38,493,301 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
alopecia  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
bacterial meningitis  (ISO)
borna disease  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Carotid Artery Injuries  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fibrosis  (ISO)
gastrointestinal stromal tumor  (ISO)
glomerulonephritis  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kyphosis  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Neoplastic Cell Transformation  (ISO)
nephritis  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (ISO)
pancreatitis  (ISO)
Paralysis  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
periventricular leukomalacia  (ISO)
Plaque, Atherosclerotic  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Ischemia  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Vitamin A Deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
ATP generation from poly-ADP-D-ribose  (ISO)
base-excision repair  (ISO)
behavioral response to cocaine  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to superoxide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to UV  (ISO)
cellular response to zinc ion  (ISO)
DNA ADP-ribosylation  (ISO)
DNA metabolic process  (ISO)
double-strand break repair  (ISO)
mitochondrial DNA metabolic process  (ISO)
mitochondrial DNA repair  (ISO)
mitochondrion organization  (ISO)
negative regulation of ATP biosynthetic process  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of telomere maintenance via telomere lengthening  (ISO)
peptidyl-glutamic acid poly-ADP-ribosylation  (ISO)
peptidyl-serine ADP-ribosylation  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of double-strand break repair via homologous recombination  (ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of myofibroblast differentiation  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of single strand break repair  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
protein ADP-ribosylation  (ISO)
protein auto-ADP-ribosylation  (ISO)
protein autoprocessing  (ISO)
protein modification process  (ISO)
protein poly-ADP-ribosylation  (ISO)
regulation of catalytic activity  (ISO)
regulation of DNA methylation  (ISO)
regulation of growth rate  (ISO)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of protein localization  (ISO)
regulation of single strand break repair  (ISO)
regulation of SMAD protein complex assembly  (ISO)
response to aldosterone  (ISO)
response to gamma radiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
telomere maintenance  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
voluntary musculoskeletal movement  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PARP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,503,072 - 38,542,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,503,067 - 38,542,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,984,470 - 38,024,231 (+)NCBI
ROS_Cfam_1.0738,336,543 - 38,376,496 (+)NCBI
UMICH_Zoey_3.1738,175,521 - 38,215,272 (+)NCBI
UNSW_CanFamBas_1.0738,182,459 - 38,222,219 (+)NCBI
UU_Cfam_GSD_1.0738,453,305 - 38,493,301 (+)NCBI
PARP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1226,360,210 - 226,408,154 (-)EnsemblGRCh38hg38GRCh38
GRCh381226,360,691 - 226,408,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371226,548,392 - 226,595,794 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,615,015 - 224,662,424 (-)NCBINCBI36hg18NCBI36
Build 341222,855,240 - 222,902,526NCBI
Celera1199,739,310 - 199,786,722 (-)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1197,065,678 - 197,113,094 (-)NCBIHuRef
CHM1_11227,821,256 - 227,868,667 (-)NCBICHM1_1
Parp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,396,456 - 180,428,564 (+)NCBIGRCm39mm39
GRCm39 Ensembl1180,396,489 - 180,428,819 (+)Ensembl
GRCm381180,568,891 - 180,600,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,568,924 - 180,601,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,499,106 - 182,531,385 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,405,650 - 182,437,929 (+)NCBImm8
Celera1187,634,811 - 187,667,071 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.44NCBI
Parp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,307,593 - 92,339,406 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1392,307,586 - 92,339,404 (+)Ensembl
Rnor_6.01398,857,255 - 98,889,444 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,857,177 - 98,889,716 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,859,760 - 103,891,949 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,309,670 - 96,341,486 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,498,605 - 96,530,421 (+)NCBI
Celera1391,853,812 - 91,885,580 (+)NCBICelera
Cytogenetic Map13q26NCBI
Parp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955489520,875 - 557,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955489520,875 - 557,609 (-)NCBIChiLan1.0ChiLan1.0
PARP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11206,812,981 - 206,860,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,812,981 - 206,860,356 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01201,820,355 - 201,867,673 (-)NCBIMhudiblu_PPA_v0panPan3
Parp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,599,711 - 51,644,827 (+)NCBI
SpeTri2.0NW_0049365263,102,468 - 3,147,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,203,159 - 14,241,197 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,203,157 - 14,241,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,598,164 - 16,636,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,350,798 - 3,405,040 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660553,353,198 - 3,400,806 (+)NCBIVero_WHO_p1.0
Parp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624807446,662 - 478,571 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 18 2 6 2 6 6 12 8 10 6
Low 4 4 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000025541   ⟹   ENSCAFP00000023715
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl738,503,067 - 38,542,127 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000045712   ⟹   ENSCAFP00000037955
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl738,503,067 - 38,542,127 (+)Ensembl
RefSeq Acc Id: XM_038481459   ⟹   XP_038337387
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1738,175,521 - 38,215,272 (+)NCBI
RefSeq Acc Id: XM_038542813   ⟹   XP_038398741
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0738,453,305 - 38,493,301 (+)NCBI
RefSeq Acc Id: XM_038569295   ⟹   XP_038425223
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha737,984,470 - 38,024,231 (+)NCBI
RefSeq Acc Id: XM_038606956   ⟹   XP_038462884
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0738,182,459 - 38,222,219 (+)NCBI
RefSeq Acc Id: XM_038671656   ⟹   XP_038527584
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0738,336,543 - 38,376,496 (+)NCBI
Reference Sequences
RefSeq Acc Id: ENSCAFP00000023715   ⟸   ENSCAFT00000025541
RefSeq Acc Id: ENSCAFP00000037955   ⟸   ENSCAFT00000045712
RefSeq Acc Id: XP_038337387   ⟸   XM_038481459
RefSeq Acc Id: XP_038462884   ⟸   XM_038606956
RefSeq Acc Id: XP_038527584   ⟸   XM_038671656
RefSeq Acc Id: XP_038425223   ⟸   XM_038569295
RefSeq Acc Id: XP_038398741   ⟸   XM_038542813


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016089 Ensembl
NCBI Gene PARP1 ENTREZGENE
VGNC ID VGNC:53874 ENTREZGENE