FGF7 (fibroblast growth factor 7) - Rat Genome Database

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Gene: FGF7 (fibroblast growth factor 7) Canis lupus familiaris
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Symbol: FGF7
Name: fibroblast growth factor 7
RGD ID: 12243013
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); growth factor activity (ortholog); heparin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); branching involved in salivary gland morphogenesis (ortholog); endothelial cell proliferation (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); cervical squamous cell carcinoma (ortholog); cleft lip (ortholog); FOUND IN extracellular space (ortholog); Golgi apparatus (ortholog); INTERACTS WITH hydrogen chloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FGF-7; fibroblast growth factor 7 (keratinocyte growth factor); HBGF-7; heparin-binding growth factor 7; keratinocyte growth factor; KGF
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13015,555,016 - 15,608,230 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3015,555,266 - 15,606,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3015,481,488 - 15,531,854 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03015,698,949 - 15,751,444 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3015,501,581 - 15,752,197 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13015,623,415 - 15,673,818 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03015,739,231 - 15,789,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03015,843,740 - 15,894,109 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
animal organ morphogenesis  (IBA,IEA)
branching involved in salivary gland morphogenesis  (ISO)
carbohydrate phosphorylation  (IEA)
cell differentiation  (IBA,IEA)
endothelial cell proliferation  (ISO)
epithelial cell proliferation  (ISO)
fibroblast growth factor receptor signaling pathway  (IBA,IEA,ISO)
galactose metabolic process  (IEA)
hair follicle morphogenesis  (ISO)
lung development  (IBA,IEA,ISO)
mesenchymal cell proliferation  (ISO)
myoblast proliferation  (ISO)
ovarian follicle development  (ISO)
phosphatidylcholine biosynthetic process  (ISO)
phospholipid biosynthetic process  (ISO)
positive chemotaxis  (IBA,IEA)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IBA,IEA)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IBA,IEA,ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of gene expression  (IBA,IEA)
positive regulation of keratinocyte migration  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IBA,IEA)
protein localization to cell surface  (ISO)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (ISO)
regulation of cell migration  (IBA,IEA)
secretion by lung epithelial cell involved in lung growth  (ISO)
signal transduction  (IEA)
surfactant homeostasis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8634153   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13015,555,016 - 15,608,230 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3015,555,266 - 15,606,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3015,481,488 - 15,531,854 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03015,698,949 - 15,751,444 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3015,501,581 - 15,752,197 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13015,623,415 - 15,673,818 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03015,739,231 - 15,789,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03015,843,740 - 15,894,109 (+)NCBIUU_Cfam_GSD_1.0
FGF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381549,423,242 - 49,488,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1549,423,237 - 49,488,775 (+)EnsemblGRCh38hg38GRCh38
GRCh371549,715,439 - 49,780,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361547,502,751 - 47,566,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 341547,502,750 - 47,566,815NCBI
Celera1526,608,551 - 26,672,713 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1526,547,279 - 26,611,441 (+)NCBIHuRef
CHM1_11549,833,504 - 49,897,659 (+)NCBICHM1_1
T2T-CHM13v2.01547,231,591 - 47,297,131 (+)NCBIT2T-CHM13v2.0
Fgf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,876,578 - 125,933,105 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2125,876,578 - 125,933,105 (+)EnsemblGRCm39 Ensembl
GRCm382126,034,658 - 126,091,185 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,034,658 - 126,091,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv372125,860,394 - 125,916,921 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362125,726,225 - 125,781,966 (+)NCBIMGSCv36mm8
Celera2127,270,998 - 127,337,627 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Fgf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83133,734,557 - 133,786,678 (+)NCBIGRCr8
mRatBN7.23113,280,448 - 113,333,279 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,281,283 - 113,332,929 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,157,853 - 117,207,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03125,753,368 - 125,802,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,413,729 - 123,462,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03118,315,859 - 118,368,464 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3118,317,761 - 118,366,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,840,157 - 124,892,611 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43113,468,427 - 113,517,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13113,373,999 - 113,423,111 (+)NCBI
Celera3112,134,799 - 112,183,941 (+)NCBICelera
Cytogenetic Map3q36NCBI
Fgf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,632,858 - 4,686,860 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,633,542 - 4,686,768 (-)NCBIChiLan1.0ChiLan1.0
FGF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21638,669,957 - 38,734,413 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11542,853,936 - 42,921,604 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01528,378,339 - 28,442,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl1546,702,119 - 46,770,163 (+)Ensemblpanpan1.1panPan2
Fgf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864093,787,837 - 93,847,287 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647111,635,876 - 11,693,821 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647111,636,733 - 11,692,782 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,215,882 - 122,277,750 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11122,215,878 - 122,278,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,926,619 - 135,928,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12633,802,349 - 33,867,743 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2633,802,328 - 33,867,333 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048107,261,064 - 107,330,391 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473110,413,645 - 10,468,690 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473110,413,715 - 10,468,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF7
452 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 5 1 6 5
Low 5 5 13 1 1 1 5 6 10 4 1
Below cutoff 8 5 5 2 7

Sequence


RefSeq Acc Id: ENSCAFT00000023682   ⟹   ENSCAFP00000021986
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3015,555,266 - 15,606,521 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845038855   ⟹   ENSCAFP00845030429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3015,501,581 - 15,751,737 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845038976   ⟹   ENSCAFP00845030527
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3015,501,581 - 15,638,826 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845039077   ⟹   ENSCAFP00845030607
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3015,507,914 - 15,751,737 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845039189   ⟹   ENSCAFP00845030694
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3015,698,945 - 15,752,197 (+)Ensembl
RefSeq Acc Id: NM_001003237   ⟹   NP_001003237
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13015,556,114 - 15,606,484 (+)NCBI
Dog10K_Boxer_Tasha3015,481,488 - 15,531,854 (+)NCBI
ROS_Cfam_1.03015,700,026 - 15,750,458 (+)NCBI
UMICH_Zoey_3.13015,623,415 - 15,673,818 (+)NCBI
UNSW_CanFamBas_1.03015,739,231 - 15,789,330 (+)NCBI
UU_Cfam_GSD_1.03015,843,740 - 15,894,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038441733   ⟹   XP_038297661
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03015,698,949 - 15,751,444 (+)NCBI
RefSeq Acc Id: NP_001003237   ⟸   NM_001003237
- Peptide Label: precursor
- UniProtKB: P79150 (UniProtKB/Swiss-Prot),   A0A7U3JWH0 (UniProtKB/TrEMBL),   A0A8C0L4Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000021986   ⟸   ENSCAFT00000023682
RefSeq Acc Id: XP_038297661   ⟸   XM_038441733
- Peptide Label: isoform X1
- UniProtKB: P79150 (UniProtKB/Swiss-Prot),   A0A7U3JWH0 (UniProtKB/TrEMBL),   A0A8C0L4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845030607   ⟸   ENSCAFT00845039077
RefSeq Acc Id: ENSCAFP00845030527   ⟸   ENSCAFT00845038976
RefSeq Acc Id: ENSCAFP00845030694   ⟸   ENSCAFT00845039189
RefSeq Acc Id: ENSCAFP00845030429   ⟸   ENSCAFT00845038855

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014895 UniProtKB/Swiss-Prot
  ENSCAFG00000014923 Ensembl
  ENSCAFG00030007447 UniProtKB/Swiss-Prot
  ENSCAFG00040019496 UniProtKB/Swiss-Prot
  ENSCAFG00805029342 UniProtKB/Swiss-Prot
  ENSCAFG00845022021 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023682.5 UniProtKB/Swiss-Prot
  ENSCAFT00030013677.1 UniProtKB/Swiss-Prot
  ENSCAFT00040036077.1 UniProtKB/Swiss-Prot
  ENSCAFT00805053341 UniProtKB/Swiss-Prot
  ENSCAFT00845038855.1 UniProtKB/TrEMBL
  ENSCAFT00845039189 ENTREZGENE
  ENSCAFT00845039189.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.340 UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.30.70.3170 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactokinase UniProtKB/TrEMBL
  Galactokinase_CS UniProtKB/TrEMBL
  GalKase_N UniProtKB/TrEMBL
  GHMP_kinase_C_sf UniProtKB/TrEMBL
  GHMP_kinase_N_dom UniProtKB/TrEMBL
  GHMP_knse_ATP-bd_CS UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mevalonate/galactokinase UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
KEGG Report cfa:403915 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene FGF7 ENTREZGENE
PANTHER GALACTOKINASE-RELATED UniProtKB/TrEMBL
  MEVALONATE KINASE/GALACTOKINASE UniProtKB/TrEMBL
  PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GalKase_gal_bdg UniProtKB/TrEMBL
  GHMP_kinases_N UniProtKB/TrEMBL
PIRSF Galactokinase UniProtKB/TrEMBL
PRINTS GALCTOKINASE UniProtKB/TrEMBL
  HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEVGALKINASE UniProtKB/TrEMBL
PROSITE GALACTOKINASE UniProtKB/TrEMBL
  GHMP_KINASES_ATP UniProtKB/TrEMBL
  HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54211 UniProtKB/TrEMBL
  SSF55060 UniProtKB/TrEMBL
UniProt A0A7U3JWH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0L4Q6 ENTREZGENE
  A0A8I3PE38_CANLF UniProtKB/TrEMBL
  FGF7_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:40853 ENTREZGENE