SLC36A4 (solute carrier family 36 member 4) - Rat Genome Database

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Gene: SLC36A4 (solute carrier family 36 member 4) Canis lupus familiaris
Analyze
Symbol: SLC36A4
Name: solute carrier family 36 member 4
RGD ID: 12238721
Description: ENCODES a protein that exhibits L-alanine transmembrane transporter activity (inferred); L-proline transmembrane transporter activity (inferred); L-tryptophan transmembrane transporter activity (inferred); INVOLVED IN amino acid transmembrane transport (inferred); L-alanine transport (inferred); proline transmembrane transport (inferred); PARTICIPATES IN nicotinamide adenine dinucleotide metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); FOUND IN lysosomal membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proton-coupled amino acid transporter 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1217,476,291 - 7,523,463 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl217,475,648 - 7,520,331 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha217,474,725 - 7,538,019 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0217,635,696 - 7,698,997 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl217,635,686 - 7,698,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1217,421,675 - 7,481,882 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0217,490,947 - 7,554,286 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0217,535,348 - 7,598,628 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SLC36A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1217,476,291 - 7,523,463 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl217,475,648 - 7,520,331 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha217,474,725 - 7,538,019 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0217,635,696 - 7,698,997 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl217,635,686 - 7,698,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1217,421,675 - 7,481,882 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0217,490,947 - 7,554,286 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0217,535,348 - 7,598,628 (+)NCBIUU_Cfam_GSD_1.0
SLC36A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381193,144,174 - 93,197,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1193,144,174 - 93,197,991 (-)EnsemblGRCh38hg38GRCh38
GRCh371192,877,340 - 92,931,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361192,520,498 - 92,570,743 (-)NCBINCBI36Build 36hg18NCBI36
Build 341192,520,499 - 92,570,743NCBI
Celera1190,179,804 - 90,230,049 (-)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1188,965,724 - 89,015,692 (-)NCBIHuRef
CHM1_11192,763,842 - 92,814,140 (-)NCBICHM1_1
T2T-CHM13v2.01193,066,962 - 93,120,802 (-)NCBIT2T-CHM13v2.0
Slc36a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39915,621,034 - 15,653,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl915,621,034 - 15,654,657 (+)EnsemblGRCm39 Ensembl
GRCm38915,709,738 - 15,742,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl915,709,738 - 15,743,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37915,514,213 - 15,543,233 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36915,460,162 - 15,489,182 (+)NCBIMGSCv36mm8
Celera912,988,023 - 13,017,043 (+)NCBICelera
Cytogenetic Map9A2NCBI
cM Map95.12NCBI
Slc36a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8820,801,256 - 20,834,046 (+)NCBIGRCr8
mRatBN7.2812,519,613 - 12,552,671 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl812,519,943 - 12,552,031 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx816,506,726 - 16,536,678 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0814,804,480 - 14,834,432 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0812,782,331 - 12,813,520 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0814,238,975 - 14,271,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl814,239,594 - 14,269,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0814,329,327 - 14,360,233 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4812,504,817 - 12,534,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1812,504,818 - 12,533,407 (+)NCBI
Celera813,985,685 - 14,015,651 (+)NCBICelera
Cytogenetic Map8q12NCBI
Slc36a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554141,236,141 - 1,285,610 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554141,236,179 - 1,286,680 (+)NCBIChiLan1.0ChiLan1.0
SLC36A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2994,008,249 - 94,062,806 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11195,097,192 - 95,150,608 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01188,164,083 - 88,218,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11191,662,625 - 91,880,929 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1191,663,479 - 91,713,388 (-)Ensemblpanpan1.1panPan2
Slc36a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494778,289,864 - 78,363,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366741,567,675 - 1,601,635 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366741,567,718 - 1,601,561 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC36A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl925,639,387 - 25,689,028 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1925,639,370 - 25,689,177 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2928,983,529 - 29,033,251 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC36A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1184,393,698 - 84,487,984 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl184,398,027 - 84,445,971 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604341,344,168 - 41,395,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc36a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473537,791,206 - 37,831,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473537,791,690 - 37,831,749 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC36A4
803 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 6 2
Low 5 5 18 6 6 6 6 3 6 8 8 6
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006811   ⟹   ENSCAFP00000006304
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl217,475,648 - 7,519,448 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000061380   ⟹   ENSCAFP00000062227
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl217,475,648 - 7,520,331 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040765   ⟹   ENSCAFP00845031915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl217,635,686 - 7,698,993 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040812   ⟹   ENSCAFP00845031954
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl217,635,686 - 7,695,991 (+)Ensembl
RefSeq Acc Id: XM_038429788   ⟹   XP_038285716
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0217,635,696 - 7,698,997 (+)NCBI
RefSeq Acc Id: XM_038456312   ⟹   XP_038312240
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha217,474,725 - 7,538,019 (+)NCBI
RefSeq Acc Id: XM_038505200   ⟹   XP_038361128
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1217,421,675 - 7,481,882 (+)NCBI
RefSeq Acc Id: XM_038568331   ⟹   XP_038424259
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0217,535,348 - 7,598,628 (+)NCBI
RefSeq Acc Id: XM_038632475   ⟹   XP_038488403
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0217,490,947 - 7,554,286 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000006304   ⟸   ENSCAFT00000006811
RefSeq Acc Id: ENSCAFP00000062227   ⟸   ENSCAFT00000061380
RefSeq Acc Id: XP_038361128   ⟸   XM_038505200
RefSeq Acc Id: XP_038488403   ⟸   XM_038632475
RefSeq Acc Id: XP_038285716   ⟸   XM_038429788
- UniProtKB: A0A8I3S3F6 (UniProtKB/TrEMBL),   A0A8P0TDU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038312240   ⟸   XM_038456312
- UniProtKB: A0A8I3S3F6 (UniProtKB/TrEMBL),   A0A8P0TDU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038424259   ⟸   XM_038568331
- UniProtKB: A0A8I3S3F6 (UniProtKB/TrEMBL),   A0A8P0TDU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845031915   ⟸   ENSCAFT00845040765
RefSeq Acc Id: ENSCAFP00845031954   ⟸   ENSCAFT00845040812
Protein Domains
Amino acid transporter transmembrane


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004243 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845023100 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000061380.2 UniProtKB/TrEMBL
  ENSCAFT00845040765 ENTREZGENE
  ENSCAFT00845040765.1 UniProtKB/TrEMBL
  ENSCAFT00845040812.1 UniProtKB/TrEMBL
InterPro AA_transpt_TM UniProtKB/TrEMBL
NCBI Gene SLC36A4 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  PROTON-COUPLED AMINO ACID TRANSPORTER 4 UniProtKB/TrEMBL
Pfam Aa_trans UniProtKB/TrEMBL
UniProt A0A8I3PDX3_CANLF UniProtKB/TrEMBL
  A0A8I3S3F6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TDU7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46385 ENTREZGENE