PRSS38 (serine protease 38) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PRSS38 (serine protease 38) Canis lupus familiaris
Analyze
Symbol: PRSS38
Name: serine protease 38
RGD ID: 12237939
Description: ENCODES a protein that exhibits serine-type endopeptidase activity (inferred); serine-type peptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); parathyroid carcinoma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protease, serine 38
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114997,712 - 1,007,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14998,162 - 1,008,129 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14141,876 - 151,599 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014720,726 - 730,445 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14721,176 - 730,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114911,282 - 920,994 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014692,008 - 701,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014680,631 - 690,342 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRSS38
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114997,712 - 1,007,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14998,162 - 1,008,129 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14141,876 - 151,599 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014720,726 - 730,445 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14721,176 - 730,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114911,282 - 920,994 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014692,008 - 701,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014680,631 - 690,342 (-)NCBIUU_Cfam_GSD_1.0
PRSS38
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381227,815,675 - 227,846,470 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1227,815,675 - 227,846,470 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,003,376 - 228,034,171 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,070,041 - 226,100,794 (+)NCBINCBI36Build 36hg18NCBI36
Celera1201,195,098 - 201,225,534 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,519,556 - 198,549,967 (+)NCBIHuRef
CHM1_11229,276,159 - 229,306,607 (+)NCBICHM1_1
T2T-CHM13v2.01227,004,591 - 227,035,389 (+)NCBIT2T-CHM13v2.0
Prss38
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,262,252 - 59,266,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,263,495 - 59,266,483 (-)EnsemblGRCm39 Ensembl
GRCm381159,371,426 - 59,375,653 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,372,669 - 59,375,657 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,186,171 - 59,189,155 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,188,857 - 59,193,796 (-)NCBIMGSCv36mm8
Celera1164,138,627 - 64,141,612 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.7NCBI
Prss38
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,658,888 - 44,665,089 (-)NCBIGRCr8
mRatBN7.21044,159,339 - 44,163,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,159,346 - 44,162,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,853,769 - 48,856,911 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,344,140 - 48,347,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,847,743 - 43,850,885 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,723,663 - 45,731,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,723,914 - 45,726,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,479,345 - 45,482,470 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,678,994 - 45,681,860 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1043,421,130 - 43,424,272 (-)NCBICelera
Cytogenetic Map10q22NCBI
Prss38
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955581455,309 - 458,793 (-)NCBIChiLan1.0ChiLan1.0
PRSS38
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,757,660 - 21,791,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,695,797 - 21,729,345 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,185,888 - 203,249,622 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,195,825 - 208,226,371 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,195,825 - 208,226,371 (+)Ensemblpanpan1.1panPan2
Prss38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,934,907 - 87,942,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936864277,217 - 279,194 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936864276,834 - 279,194 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS38
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,858,604 - 1,887,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,858,861 - 1,887,379 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,741,247 - 1,769,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss38
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937747,419 - 750,488 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRSS38
70 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system integumental system nervous system reproductive system respiratory system
High
Medium
Low 8
Below cutoff 6 2 5 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022427188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_532412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000001834   ⟹   ENSCAFP00000001690
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl14998,162 - 1,008,129 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014175   ⟹   ENSCAFP00845010990
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl14721,176 - 730,431 (-)Ensembl
RefSeq Acc Id: XM_022427188   ⟹   XP_022282896
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.114997,712 - 1,007,495 (-)NCBI
Dog10K_Boxer_Tasha14141,876 - 151,599 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038494151   ⟹   XP_038350079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.114911,282 - 920,992 (-)NCBI
RefSeq Acc Id: XM_038494152   ⟹   XP_038350080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.114911,282 - 920,994 (-)NCBI
RefSeq Acc Id: XM_038556448   ⟹   XP_038412376
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.014680,631 - 690,340 (-)NCBI
RefSeq Acc Id: XM_038556449   ⟹   XP_038412377
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.014680,631 - 690,342 (-)NCBI
RefSeq Acc Id: XM_038620378   ⟹   XP_038476306
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.014692,008 - 701,732 (-)NCBI
RefSeq Acc Id: XM_038620379   ⟹   XP_038476307
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.014692,008 - 701,731 (-)NCBI
RefSeq Acc Id: XM_038620380   ⟹   XP_038476308
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.014692,008 - 701,733 (-)NCBI
RefSeq Acc Id: XM_038686066   ⟹   XP_038541994
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.014720,726 - 730,443 (-)NCBI
RefSeq Acc Id: XM_038686067   ⟹   XP_038541995
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.014720,726 - 730,445 (-)NCBI
RefSeq Acc Id: XM_532412   ⟹   XP_532412
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.114997,712 - 1,007,489 (-)NCBI
Dog10K_Boxer_Tasha14141,877 - 151,599 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_532412   ⟸   XM_532412
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RVU0 (UniProtKB/TrEMBL),   A0A8P0S7E3 (UniProtKB/TrEMBL),   A0A8C0JVU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022282896   ⟸   XM_022427188
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JVU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001690   ⟸   ENSCAFT00000001834
RefSeq Acc Id: XP_038350080   ⟸   XM_038494152
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038350079   ⟸   XM_038494151
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038476308   ⟸   XM_038620380
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038476306   ⟸   XM_038620378
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038476307   ⟸   XM_038620379
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038541995   ⟸   XM_038686067
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JVU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541994   ⟸   XM_038686066
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RVU0 (UniProtKB/TrEMBL),   A0A8P0S7E3 (UniProtKB/TrEMBL),   A0A8C0JVU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412377   ⟸   XM_038556449
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JVU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412376   ⟸   XM_038556448
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JVU4 (UniProtKB/TrEMBL),   A0A8I3RVU0 (UniProtKB/TrEMBL),   A0A8P0S7E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845010990   ⟸   ENSCAFT00845014175
Protein Domains
Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001184 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845008050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001834.5 UniProtKB/TrEMBL
  ENSCAFT00845014175 ENTREZGENE
  ENSCAFT00845014175.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene PRSS38 ENTREZGENE
PANTHER CHYMOTRYPSIN-RELATED UniProtKB/TrEMBL
  SERINE PROTEASE 38 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A0A8C0JVU4 ENTREZGENE
  A0A8I3RVU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0S7E3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45069 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-07 PRSS38  serine protease 38    protease, serine 38  Symbol and/or name change 5135510 APPROVED