TBX18 (T-box transcription factor 18) - Rat Genome Database

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Gene: TBX18 (T-box transcription factor 18) Canis lupus familiaris
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Symbol: TBX18
Name: T-box transcription factor 18
RGD ID: 12237051
Description: ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); protein homodimerization activity (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anterior/posterior axis specification (ortholog); cell differentiation (ortholog); ASSOCIATED WITH CAKUT2 (ortholog); chronic kidney disease (ortholog); FOUND IN RNA polymerase II transcription repressor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: T-box transcription factor TBX18; T-box 18; T-box transcription factor TBX18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11244,901,076 - 44,929,730 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1244,873,119 - 44,929,205 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1244,715,143 - 44,743,697 (-)NCBI
ROS_Cfam_1.01245,667,650 - 45,696,229 (-)NCBI
UMICH_Zoey_3.11245,001,870 - 45,030,386 (-)NCBI
UNSW_CanFamBas_1.01244,937,063 - 44,965,596 (-)NCBI
UU_Cfam_GSD_1.01245,119,019 - 45,147,578 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
TBX18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11244,901,076 - 44,929,730 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1244,873,119 - 44,929,205 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1244,715,143 - 44,743,697 (-)NCBI
ROS_Cfam_1.01245,667,650 - 45,696,229 (-)NCBI
UMICH_Zoey_3.11245,001,870 - 45,030,386 (-)NCBI
UNSW_CanFamBas_1.01244,937,063 - 44,965,596 (-)NCBI
UU_Cfam_GSD_1.01245,119,019 - 45,147,578 (-)NCBI
TBX18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl684,687,351 - 84,764,598 (-)EnsemblGRCh38hg38GRCh38
GRCh38684,666,810 - 84,764,598 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37685,442,214 - 85,474,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36685,500,876 - 85,530,618 (-)NCBINCBI36hg18NCBI36
Build 34685,510,715 - 85,529,036NCBI
Celera685,871,383 - 85,901,128 (-)NCBI
Cytogenetic Map6q14.3NCBI
HuRef682,665,241 - 82,696,981 (-)NCBIHuRef
CHM1_1685,539,567 - 85,571,307 (-)NCBICHM1_1
Tbx18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39987,584,853 - 87,613,313 (-)NCBIGRCm39mm39
GRCm39 Ensembl987,584,853 - 87,613,313 (-)Ensembl
GRCm38987,702,800 - 87,731,260 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl987,702,800 - 87,731,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv37987,597,635 - 87,626,095 (-)NCBIGRCm37mm9NCBIm37
MGSCv36987,502,145 - 87,529,206 (-)NCBImm8
Celera984,762,550 - 84,791,101 (-)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.06NCBI
Tbx18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2888,652,054 - 88,680,081 (-)NCBI
Rnor_6.0 Ensembl895,359,354 - 95,387,363 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0895,359,354 - 95,387,363 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0894,860,116 - 94,888,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4892,984,336 - 93,012,343 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1892,982,189 - 93,031,958 (-)NCBI
Celera888,229,534 - 88,257,537 (-)NCBICelera
Cytogenetic Map8q31NCBI
Tbx18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541112,194,550 - 12,232,374 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541112,194,560 - 12,232,374 (-)NCBIChiLan1.0ChiLan1.0
TBX18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1685,906,500 - 85,938,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl685,862,810 - 85,938,799 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0682,621,987 - 82,654,137 (-)NCBIMhudiblu_PPA_v0panPan3
Tbx18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494680,074,742 - 80,104,499 (-)NCBI
SpeTri2.0NW_0049365106,366,450 - 6,396,056 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl153,837,454 - 53,867,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1153,836,939 - 53,867,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2160,192,672 - 60,223,150 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TBX18
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1139,407,384 - 9,441,157 (-)NCBI
ChlSab1.1 Ensembl139,411,004 - 9,439,642 (-)Ensembl
Tbx18
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247999,694,167 - 9,721,468 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 4 16 6 1 10 8 5 6
Below cutoff 5 1 6 6 6 6 5 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000004787   ⟹   ENSCAFP00000004433
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1244,903,351 - 44,929,205 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000072004   ⟹   ENSCAFP00000049635
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1244,873,119 - 44,928,359 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093899   ⟹   ENSCAFP00000055663
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1244,903,351 - 44,928,242 (-)Ensembl
RefSeq Acc Id: XM_022426316   ⟹   XP_022282024
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11244,901,076 - 44,928,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038492360   ⟹   XP_038348288
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11245,001,870 - 45,030,386 (-)NCBI
RefSeq Acc Id: XM_038554648   ⟹   XP_038410576
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01245,119,019 - 45,147,578 (-)NCBI
RefSeq Acc Id: XM_038618518   ⟹   XP_038474446
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01244,937,063 - 44,965,596 (-)NCBI
RefSeq Acc Id: XM_038684080   ⟹   XP_038540008
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01245,667,650 - 45,696,229 (-)NCBI
RefSeq Acc Id: XM_539024   ⟹   XP_539024
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11244,901,076 - 44,929,730 (-)NCBI
Dog10K_Boxer_Tasha1244,715,143 - 44,743,697 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038348288 (Get FASTA)   NCBI Sequence Viewer  
  XP_038410576 (Get FASTA)   NCBI Sequence Viewer  
  XP_038474446 (Get FASTA)   NCBI Sequence Viewer  
  XP_038540008 (Get FASTA)   NCBI Sequence Viewer  
  XP_539024 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_539024   ⟸   XM_539024
- UniProtKB: E2R062 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022282024   ⟸   XM_022426316
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000055663   ⟸   ENSCAFT00000093899
RefSeq Acc Id: ENSCAFP00000004433   ⟸   ENSCAFT00000004787
RefSeq Acc Id: ENSCAFP00000049635   ⟸   ENSCAFT00000072004
RefSeq Acc Id: XP_038348288   ⟸   XM_038492360
RefSeq Acc Id: XP_038474446   ⟸   XM_038618518
RefSeq Acc Id: XP_038540008   ⟸   XM_038684080
RefSeq Acc Id: XP_038410576   ⟸   XM_038554648

Promoters
RGD ID:13685497
Promoter ID:EPDNEW_C3565
Type:initiation region
Name:TBX18_1
Description:T-box 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11244,929,134 - 44,929,194EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002987 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000004433 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000049635 UniProtKB/TrEMBL
  ENSCAFP00000055663 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004787 UniProtKB/TrEMBL
  ENSCAFT00000072004 UniProtKB/TrEMBL
  ENSCAFT00000093899 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
NCBI Gene TBX18 ENTREZGENE
PANTHER PTHR11267 UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
PRINTS TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt A0A5F4C5U7_CANLF UniProtKB/TrEMBL
  A0A5F4CQG3_CANLF UniProtKB/TrEMBL
  E2R062 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:57235 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 TBX18  T-box transcription factor 18  TBX18  T-box 18  Symbol and/or name change 5135510 APPROVED