E4F1 (E4F transcription factor 1) - Rat Genome Database

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Gene: E4F1 (E4F transcription factor 1) Canis lupus familiaris
Analyze
Symbol: E4F1
Name: E4F transcription factor 1
RGD ID: 12236346
Description: ENCODES a protein that exhibits cAMP response element binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA replication (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of mitotic cell cycle, embryonic (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); developmental and epileptic encephalopathy 1 (ortholog); endometrial carcinoma (ortholog); FOUND IN nuclear body (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription factor E4F1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,743,346 - 38,752,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,743,355 - 38,752,403 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,982,727 - 39,991,786 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,051,930 - 39,060,985 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,051,930 - 39,065,832 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,736,943 - 38,745,997 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,709,267 - 38,718,322 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,187,987 - 39,197,042 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear body  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)
spindle  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
E4F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,743,346 - 38,752,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,743,355 - 38,752,403 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,982,727 - 39,991,786 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,051,930 - 39,060,985 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,051,930 - 39,065,832 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,736,943 - 38,745,997 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,709,267 - 38,718,322 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,187,987 - 39,197,042 (-)NCBIUU_Cfam_GSD_1.0
E4F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,223,591 - 2,235,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,223,580 - 2,235,742 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,273,592 - 2,285,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,213,568 - 2,225,744 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,213,589 - 2,225,743NCBI
Celera162,487,988 - 2,500,164 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,199,659 - 2,211,835 (+)NCBIHuRef
CHM1_1162,273,496 - 2,285,692 (+)NCBICHM1_1
T2T-CHM13v2.0162,245,946 - 2,258,191 (+)NCBIT2T-CHM13v2.0
E4f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,662,752 - 24,674,366 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,662,752 - 24,689,287 (-)EnsemblGRCm39 Ensembl
GRCm381724,443,778 - 24,455,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,443,778 - 24,470,313 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,580,724 - 24,592,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,171,379 - 24,182,911 (-)NCBIMGSCv36mm8
Celera1724,958,270 - 24,969,970 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.39NCBI
E4f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,978,975 - 13,999,646 (-)NCBIGRCr8
mRatBN7.21013,471,478 - 13,495,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,474,456 - 13,485,974 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,220,916 - 18,232,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,709,761 - 17,721,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,208,946 - 13,220,429 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,812,335 - 13,835,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,815,293 - 13,826,945 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,629,321 - 13,644,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,701,558 - 13,713,008 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,698,967 - 13,713,008 (-)NCBI
Celera1013,154,954 - 13,166,469 (-)NCBICelera
Cytogenetic Map10q12NCBI
E4f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,030,363 - 15,041,877 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,031,210 - 15,041,437 (-)NCBIChiLan1.0ChiLan1.0
E4F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,724,616 - 2,737,612 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,505,600 - 6,518,512 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,080,205 - 1,092,996 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,323,461 - 2,335,695 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,323,461 - 2,335,695 (+)Ensemblpanpan1.1panPan2
E4f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,879,637 - 104,898,330 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,809,882 - 1,829,157 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,811,131 - 1,829,193 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E4F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,761,356 - 39,772,262 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,757,679 - 39,773,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,408,014 - 42,418,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
E4F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,117,936 - 2,130,787 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,117,479 - 2,130,623 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,928,785 - 28,941,473 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E4f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462482438,146 - 49,019 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462482438,062 - 50,183 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in E4F1
46 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014114438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038540719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038540720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038604840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038604841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038669524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038669525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000030824   ⟹   ENSCAFP00000028658
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl638,743,355 - 38,752,403 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845008227   ⟹   ENSCAFP00845006465
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl639,051,930 - 39,065,832 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845008242   ⟹   ENSCAFP00845006479
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl639,051,930 - 39,060,972 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845008253   ⟹   ENSCAFP00845006487
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl639,051,935 - 39,060,933 (-)Ensembl
RefSeq Acc Id: XM_038479461   ⟹   XP_038335389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1638,736,943 - 38,745,997 (-)NCBI
RefSeq Acc Id: XM_038479462   ⟹   XP_038335390
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1638,736,943 - 38,745,997 (-)NCBI
RefSeq Acc Id: XM_038540719   ⟹   XP_038396647
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0639,187,987 - 39,197,042 (-)NCBI
RefSeq Acc Id: XM_038540720   ⟹   XP_038396648
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0639,187,987 - 39,197,042 (-)NCBI
RefSeq Acc Id: XM_038549614   ⟹   XP_038405542
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha639,982,727 - 39,991,786 (-)NCBI
RefSeq Acc Id: XM_038549624   ⟹   XP_038405552
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha639,982,727 - 39,991,786 (-)NCBI
RefSeq Acc Id: XM_038604840   ⟹   XP_038460768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0638,709,267 - 38,718,322 (-)NCBI
RefSeq Acc Id: XM_038604841   ⟹   XP_038460769
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0638,709,267 - 38,718,322 (-)NCBI
RefSeq Acc Id: XM_038669524   ⟹   XP_038525452
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0639,051,930 - 39,060,985 (-)NCBI
RefSeq Acc Id: XM_038669525   ⟹   XP_038525453
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0639,051,930 - 39,060,985 (-)NCBI
Ensembl Acc Id: ENSCAFP00000028658   ⟸   ENSCAFT00000030824
RefSeq Acc Id: XP_038335390   ⟸   XM_038479462
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038335389   ⟸   XM_038479461
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038460769   ⟸   XM_038604841
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038460768   ⟸   XM_038604840
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038525453   ⟸   XM_038669525
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R9Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038525452   ⟸   XM_038669524
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R9Q6 (UniProtKB/TrEMBL),   A0A8C0M2H2 (UniProtKB/TrEMBL),   A0A8C0LNK8 (UniProtKB/TrEMBL),   A0A8I3MNC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405552   ⟸   XM_038549624
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R9Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405542   ⟸   XM_038549614
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R9Q6 (UniProtKB/TrEMBL),   A0A8C0M2H2 (UniProtKB/TrEMBL),   A0A8C0LNK8 (UniProtKB/TrEMBL),   A0A8I3MNC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038396648   ⟸   XM_038540720
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R9Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038396647   ⟸   XM_038540719
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LNK8 (UniProtKB/TrEMBL),   A0A8C0M2H2 (UniProtKB/TrEMBL),   A0A8C0R9Q6 (UniProtKB/TrEMBL),   A0A8I3MNC3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845006465   ⟸   ENSCAFT00845008227
Ensembl Acc Id: ENSCAFP00845006479   ⟸   ENSCAFT00845008242
Ensembl Acc Id: ENSCAFP00845006487   ⟸   ENSCAFT00845008253
Protein Domains
C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019388 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000745 UniProtKB/TrEMBL
  ENSCAFG00040020951 UniProtKB/TrEMBL
  ENSCAFG00845004602 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030824.5 UniProtKB/TrEMBL
  ENSCAFT00000099912.1 UniProtKB/TrEMBL
  ENSCAFT00000102330.1 UniProtKB/TrEMBL
  ENSCAFT00030001290.1 UniProtKB/TrEMBL
  ENSCAFT00030001312.1 UniProtKB/TrEMBL
  ENSCAFT00040038991.1 UniProtKB/TrEMBL
  ENSCAFT00845008227.1 UniProtKB/TrEMBL
  ENSCAFT00845008242 ENTREZGENE
  ENSCAFT00845008242.1 UniProtKB/TrEMBL
  ENSCAFT00845008253.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro C2H2-ZF_domain UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene E4F1 ENTREZGENE
PANTHER DEFORMED WINGS-RELATED UniProtKB/TrEMBL
  FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED UniProtKB/TrEMBL
  GM08392P UniProtKB/TrEMBL
  IP01257P-RELATED UniProtKB/TrEMBL
  KRAB AND ZINC FINGER DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8C0LNK8 ENTREZGENE
  A0A8C0M2H2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R9Q6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MNC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MSQ1_CANLF UniProtKB/TrEMBL
  A0A8I3MU55_CANLF UniProtKB/TrEMBL
  A0A8P0PJ98_CANLF UniProtKB/TrEMBL
  A0A8P0PL69_CANLF UniProtKB/TrEMBL