MIR16-2 (microRNA mir-16-2) - Rat Genome Database

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Gene: MIR16-2 (microRNA mir-16-2) Canis lupus familiaris
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Symbol: MIR16-2
Name: microRNA mir-16-2 (Ensembl:microRNA 16-2)
RGD ID: 12235225
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-16-2; microRNA 16-2
RGD Orthologs
Human
Mouse
Rat
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,460,807 - 26,460,871 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,460,807 - 26,460,871 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,502,952 - 30,503,016 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03426,517,471 - 26,517,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,517,471 - 26,517,535 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,447,152 - 26,447,216 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,407,809 - 26,407,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,647,896 - 26,647,960 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in blood vessel morphogenesis  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA)
negative regulation of angiogenesis  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell chemotaxis to fibroblast growth factor  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endothelial cell chemotaxis  (ISO)
negative regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of mesenchymal stem cell proliferation  (ISO)
negative regulation of placenta blood vessel development  (ISO)
negative regulation of trophoblast cell migration  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
ossification  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of translation  (ISO)
regulation of glucosylceramide catabolic process  (ISO)
response to bacterium  (ISO)
response to oxygen levels  (ISO)
response to wounding  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18392026  


Genomics

Comparative Map Data
MIR16-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,460,807 - 26,460,871 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,460,807 - 26,460,871 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,502,952 - 30,503,016 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03426,517,471 - 26,517,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,517,471 - 26,517,535 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,447,152 - 26,447,216 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,407,809 - 26,407,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,647,896 - 26,647,960 (+)NCBIUU_Cfam_GSD_1.0
MIR16-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383160,404,745 - 160,404,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3160,404,745 - 160,404,825 (+)EnsemblGRCh38hg38GRCh38
GRCh373160,122,533 - 160,122,613 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,605,226 - 161,605,306 (+)NCBINCBI36Build 36hg18NCBI36
Celera3158,543,900 - 158,543,980 (+)NCBICelera
Cytogenetic Map3q25.33NCBI
HuRef3157,521,115 - 157,521,195 (+)NCBIHuRef
CHM1_13160,085,422 - 160,085,502 (+)NCBICHM1_1
T2T-CHM13v2.03163,179,357 - 163,179,437 (+)NCBIT2T-CHM13v2.0
Mir16-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39368,917,235 - 68,917,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl368,917,235 - 68,917,329 (+)EnsemblGRCm39 Ensembl
GRCm38369,009,902 - 69,009,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl369,009,902 - 69,009,996 (+)EnsemblGRCm38mm10GRCm38
MGSCv37368,813,824 - 68,813,918 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera369,117,716 - 69,117,810 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map332.15NCBI
Mir16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,555,327 - 155,555,421 (+)NCBIGRCr8
mRatBN7.22153,245,349 - 153,245,443 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2153,245,349 - 153,245,443 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2160,375,020 - 160,375,114 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,425,537 - 158,425,631 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02153,058,304 - 153,058,398 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,606,072 - 165,606,166 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,606,072 - 165,606,166 (+)EnsemblRnor6.0rn6Rnor6.0
Celera2147,596,149 - 147,596,243 (+)NCBICelera
Cytogenetic Map2q32NCBI
MIR16-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13100,083,329 - 100,083,405 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113100,083,329 - 100,083,405 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213108,388,290 - 108,388,366 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


Sequence


RefSeq Acc Id: ENSCAFT00000039915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3426,460,807 - 26,460,871 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3426,517,471 - 26,517,535 (+)Ensembl
RefSeq Acc Id: NR_049311
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13426,460,807 - 26,460,871 (+)NCBI
Dog10K_Boxer_Tasha3430,502,952 - 30,503,016 (+)NCBI
ROS_Cfam_1.03426,517,471 - 26,517,535 (+)NCBI
UMICH_Zoey_3.13426,447,152 - 26,447,216 (+)NCBI
UNSW_CanFamBas_1.03426,407,809 - 26,407,873 (+)NCBI
UU_Cfam_GSD_1.03426,647,896 - 26,647,960 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025632 Ensembl
  ENSCAFG00845027723 Ensembl, ENTREZGENE
Ensembl Transcript ENSCAFT00845048888 ENTREZGENE
miRBase MI0008084 ENTREZGENE
NCBI Gene MIR16-2 ENTREZGENE
RNAcentral URS00004BCD9C RNACentral
  URS00007E4B8B RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR16-2  microRNA mir-16-2    microRNA 16-2  Symbol and/or name change 5135510 APPROVED