ARPC4 (actin related protein 2/3 complex subunit 4) - Rat Genome Database

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Gene: ARPC4 (actin related protein 2/3 complex subunit 4) Canis lupus familiaris
Analyze
Symbol: ARPC4
Name: actin related protein 2/3 complex subunit 4
RGD ID: 12233358
Description: ENCODES a protein that exhibits actin filament binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN actin filament polymerization (inferred); Arp2/3 complex-mediated actin nucleation (inferred); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH Acute Otitis Media (ortholog); Atrioventricular Septal Defect 2 (ortholog); Developmental Delay, Language Impairment, and Ocular Abnormalities (ortholog); FOUND IN actin cytoskeleton (inferred); Arp2/3 protein complex (inferred); cell projection (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: actin related protein 2/3 complex, subunit 4, 20kDa; actin-related protein 2/3 complex subunit 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,441,994 - 8,453,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,442,788 - 8,453,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,475,085 - 8,486,194 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,471,308 - 8,482,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,471,386 - 8,482,638 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,193,771 - 8,204,888 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,538,242 - 8,549,392 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,511,901 - 8,523,027 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ARPC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,441,994 - 8,453,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,442,788 - 8,453,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,475,085 - 8,486,194 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,471,308 - 8,482,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,471,386 - 8,482,638 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,193,771 - 8,204,888 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,538,242 - 8,549,392 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,511,901 - 8,523,027 (-)NCBIUU_Cfam_GSD_1.0
ARPC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3839,792,518 - 9,807,101 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl39,792,495 - 9,807,101 (+)EnsemblGRCh38hg38GRCh38
GRCh3739,834,202 - 9,848,785 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3639,809,227 - 9,823,789 (+)NCBINCBI36Build 36hg18NCBI36
Build 3439,809,733 - 9,823,784NCBI
Celera39,768,927 - 9,783,489 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef39,770,526 - 9,785,132 (+)NCBIHuRef
CHM1_139,784,371 - 9,798,980 (+)NCBICHM1_1
T2T-CHM13v2.039,784,472 - 9,799,053 (+)NCBIT2T-CHM13v2.0
Arpc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,355,074 - 113,367,408 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,355,076 - 113,367,409 (+)EnsemblGRCm39 Ensembl
GRCm386113,378,113 - 113,390,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,378,115 - 113,390,448 (+)EnsemblGRCm38mm10GRCm38
MGSCv376113,328,107 - 113,340,441 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366113,343,890 - 113,355,426 (+)NCBIMGSCv36mm8
Celera6115,204,957 - 115,217,285 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.76NCBI
Arpc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,077,799 - 148,088,427 (+)NCBIGRCr8
mRatBN7.24146,522,255 - 146,532,784 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,522,176 - 146,532,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,906,354 - 151,916,903 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,687,205 - 147,697,754 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,308,782 - 146,319,312 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,330,457 - 145,340,985 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,330,457 - 145,340,984 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,627,502 - 208,638,030 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,259,767 - 149,271,500 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,504,671 - 149,515,469 (+)NCBI
Celera4135,079,470 - 135,089,999 (+)NCBICelera
Cytogenetic Map4q42NCBI
Arpc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,314,299 - 1,327,300 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,314,299 - 1,327,300 (+)NCBIChiLan1.0ChiLan1.0
ARPC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v229,803,718 - 9,818,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan139,808,746 - 9,822,877 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v039,744,055 - 9,758,627 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.139,981,929 - 9,996,250 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,981,934 - 9,996,250 (+)Ensemblpanpan1.1panPan2
ARPC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,056,890 - 66,123,977 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,075,926 - 66,093,986 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,145,641 - 73,168,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARPC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12245,799,225 - 45,814,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2245,799,645 - 45,814,870 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041120,751,575 - 120,766,707 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ARPC4
102 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008564   ⟹   ENSCAFP00000007935
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl208,442,788 - 8,452,962 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000085553   ⟹   ENSCAFP00000044056
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl208,442,804 - 8,453,057 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845015940   ⟹   ENSCAFP00845012402
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl208,471,386 - 8,482,638 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845015974   ⟹   ENSCAFP00845012427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl208,472,376 - 8,482,327 (-)Ensembl
RefSeq Acc Id: XM_014121591   ⟹   XP_013977066
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,441,994 - 8,453,131 (-)NCBI
Dog10K_Boxer_Tasha208,475,085 - 8,486,194 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038427010   ⟹   XP_038282938
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0208,471,308 - 8,482,420 (-)NCBI
RefSeq Acc Id: XM_038502804   ⟹   XP_038358732
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1208,193,771 - 8,204,888 (-)NCBI
RefSeq Acc Id: XM_038565726   ⟹   XP_038421654
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0208,511,901 - 8,523,027 (-)NCBI
RefSeq Acc Id: XM_038629851   ⟹   XP_038485779
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0208,538,242 - 8,549,392 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013977066   ⟸   XM_014121591
- UniProtKB: A0A8C0K6G5 (UniProtKB/TrEMBL),   A0A8C0TNK7 (UniProtKB/TrEMBL),   A0A8I3N156 (UniProtKB/TrEMBL),   A0A8I3NCZ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000007935   ⟸   ENSCAFT00000008564
RefSeq Acc Id: ENSCAFP00000044056   ⟸   ENSCAFT00000085553
RefSeq Acc Id: XP_038358732   ⟸   XM_038502804
RefSeq Acc Id: XP_038485779   ⟸   XM_038629851
RefSeq Acc Id: XP_038282938   ⟸   XM_038427010
- UniProtKB: A0A8C0K6G5 (UniProtKB/TrEMBL),   A0A8C0TNK7 (UniProtKB/TrEMBL),   A0A8I3N156 (UniProtKB/TrEMBL),   A0A8I3NCZ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421654   ⟸   XM_038565726
- UniProtKB: A0A8C0K6G5 (UniProtKB/TrEMBL),   A0A8C0TNK7 (UniProtKB/TrEMBL),   A0A8I3N156 (UniProtKB/TrEMBL),   A0A8I3NCZ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845012427   ⟸   ENSCAFT00845015974
RefSeq Acc Id: ENSCAFP00845012402   ⟸   ENSCAFT00845015940

Promoters
RGD ID:13686790
Promoter ID:EPDNEW_C4857
Type:single initiation site
Name:ARPC4_1
Description:actin related protein 2/3 complex subunit 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,449,732 - 8,449,792EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023650 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030007311 UniProtKB/TrEMBL
  ENSCAFG00040024576 UniProtKB/TrEMBL
  ENSCAFG00845009045 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008564.5 UniProtKB/TrEMBL
  ENSCAFT00030013487.1 UniProtKB/TrEMBL
  ENSCAFT00030013573.1 UniProtKB/TrEMBL
  ENSCAFT00040045789.1 UniProtKB/TrEMBL
  ENSCAFT00040045813.1 UniProtKB/TrEMBL
  ENSCAFT00845015940 ENTREZGENE
  ENSCAFT00845015940.1 UniProtKB/TrEMBL
  ENSCAFT00845015974.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1460.20 UniProtKB/TrEMBL
InterPro ARPC2/4 UniProtKB/TrEMBL
  ARPC4 UniProtKB/TrEMBL
KEGG Report cfa:106560075 UniProtKB/TrEMBL
NCBI Gene ARPC4 ENTREZGENE
PANTHER ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4 UniProtKB/TrEMBL
  PTHR22629 UniProtKB/TrEMBL
Pfam ARPC4 UniProtKB/TrEMBL
PIRSF ARPC4 UniProtKB/TrEMBL
Superfamily-SCOP SSF69645 UniProtKB/TrEMBL
UniProt A0A8C0K6G5 ENTREZGENE
  A0A8C0TNK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z6D4_CANLF UniProtKB/TrEMBL
  A0A8I3N156 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NCZ2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54574 ENTREZGENE