KPNA6 (karyopherin subunit alpha 6) - Rat Genome Database

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Gene: KPNA6 (karyopherin subunit alpha 6) Canis lupus familiaris
Analyze
Symbol: KPNA6
Name: karyopherin subunit alpha 6
RGD ID: 12231866
Description: ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); nuclear localization sequence binding (inferred); INVOLVED IN entry of viral genome into host nucleus through nuclear pore complex via importin (ortholog); maternal process involved in female pregnancy (ortholog); positive regulation of cytokine production involved in inflammatory response (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN NLS-dependent protein nuclear import complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: importin subunit alpha-7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,025,409 - 69,078,635 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,030,228 - 69,077,912 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,606,196 - 65,658,834 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,592,307 - 69,644,942 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,592,320 - 69,644,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,428,697 - 66,481,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,424,402 - 67,477,046 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,423,801 - 68,476,444 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KPNA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,025,409 - 69,078,635 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,030,228 - 69,077,912 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,606,196 - 65,658,834 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,592,307 - 69,644,942 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,592,320 - 69,644,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,428,697 - 66,481,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,424,402 - 67,477,046 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,423,801 - 68,476,444 (-)NCBIUU_Cfam_GSD_1.0
KPNA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,108,056 - 32,176,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,108,056 - 32,176,563 (+)EnsemblGRCh38hg38GRCh38
GRCh37132,573,657 - 32,642,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,346,231 - 32,414,756 (+)NCBINCBI36Build 36hg18NCBI36
Build 34132,242,749 - 32,307,867NCBI
Celera130,843,548 - 30,912,069 (+)NCBICelera
Cytogenetic Map1p35.2NCBI
HuRef130,689,950 - 30,758,546 (+)NCBIHuRef
CHM1_1132,689,241 - 32,757,720 (+)NCBICHM1_1
T2T-CHM13v2.0131,965,999 - 32,034,460 (+)NCBIT2T-CHM13v2.0
Kpna6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,537,772 - 129,566,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,537,773 - 129,566,560 (-)EnsemblGRCm39 Ensembl
GRCm384129,643,979 - 129,672,767 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,643,980 - 129,672,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv374129,321,223 - 129,350,011 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364129,146,288 - 129,175,055 (-)NCBIMGSCv36mm8
Celera4127,976,916 - 128,007,095 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.28NCBI
Kpna6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25141,988,111 - 142,021,483 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,991,568 - 142,021,120 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,692,338 - 144,707,236 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,462,164 - 146,477,056 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,458,885 - 146,473,792 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,852,738 - 147,867,600 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,850,275 - 147,886,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,581,761 - 151,594,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,783,562 - 148,793,599 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,793,600 - 148,803,633 (-)NCBI
Celera5140,466,074 - 140,479,954 (-)NCBICelera
Cytogenetic Map5q36NCBI
Kpna6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545210,492,653 - 10,542,898 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545210,493,025 - 10,542,898 (+)NCBIChiLan1.0ChiLan1.0
KPNA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11193,771,870 - 193,840,657 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,394,159 - 31,462,821 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1132,406,326 - 32,471,488 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl132,406,326 - 32,471,488 (+)Ensemblpanpan1.1panPan2
Kpna6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,343,513 - 49,405,095 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,168,310 - 15,229,902 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,168,344 - 15,229,864 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl688,611,471 - 88,656,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1688,611,128 - 88,656,281 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,613,725 - 82,640,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KPNA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,699,653 - 100,769,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20100,701,947 - 100,769,766 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603315,923,419 - 15,990,214 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpna6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,327,190 - 15,400,716 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,374,707 - 15,405,024 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KPNA6
330 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 15 2 6 12 8 10 3
Low 4 5 7 6 4 6 6 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005617653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000017097   ⟹   ENSCAFP00000015820
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl269,030,228 - 69,077,912 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845009060   ⟹   ENSCAFP00845007145
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl269,592,320 - 69,644,880 (-)Ensembl
RefSeq Acc Id: XM_005617653   ⟹   XP_005617710
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1269,025,409 - 69,054,496 (-)NCBI
Dog10K_Boxer_Tasha265,606,196 - 65,635,287 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412176   ⟹   XP_022267884
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1269,025,409 - 69,053,071 (-)NCBI
Dog10K_Boxer_Tasha265,606,196 - 65,633,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022412185   ⟹   XP_022267893
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1269,025,409 - 69,078,635 (-)NCBI
Dog10K_Boxer_Tasha265,606,196 - 65,658,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038470414   ⟹   XP_038326342
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1266,428,697 - 66,456,187 (-)NCBI
RefSeq Acc Id: XM_038470415   ⟹   XP_038326343
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1266,428,697 - 66,457,534 (-)NCBI
RefSeq Acc Id: XM_038470416   ⟹   XP_038326344
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1266,428,697 - 66,481,061 (-)NCBI
RefSeq Acc Id: XM_038470417   ⟹   XP_038326345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1266,428,697 - 66,480,396 (-)NCBI
RefSeq Acc Id: XM_038531256   ⟹   XP_038387184
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0268,423,801 - 68,451,555 (-)NCBI
RefSeq Acc Id: XM_038531257   ⟹   XP_038387185
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0268,423,801 - 68,452,904 (-)NCBI
RefSeq Acc Id: XM_038531258   ⟹   XP_038387186
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0268,423,801 - 68,476,444 (-)NCBI
RefSeq Acc Id: XM_038595478   ⟹   XP_038451406
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0267,424,402 - 67,452,152 (-)NCBI
RefSeq Acc Id: XM_038595479   ⟹   XP_038451407
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0267,424,402 - 67,453,501 (-)NCBI
RefSeq Acc Id: XM_038595480   ⟹   XP_038451408
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0267,424,402 - 67,477,046 (-)NCBI
RefSeq Acc Id: XM_038659562   ⟹   XP_038515490
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,592,307 - 69,620,060 (-)NCBI
RefSeq Acc Id: XM_038659563   ⟹   XP_038515491
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,592,307 - 69,621,409 (-)NCBI
RefSeq Acc Id: XM_038659564   ⟹   XP_038515492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,592,307 - 69,644,942 (-)NCBI
RefSeq Acc Id: XM_038659565   ⟹   XP_038515493
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,592,307 - 69,644,277 (-)NCBI
RefSeq Acc Id: XP_005617710   ⟸   XM_005617653
- Peptide Label: isoform X3
- UniProtKB: A0A8C0LNI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022267893   ⟸   XM_022412185
- Peptide Label: isoform X4
- UniProtKB: A0A8C0P0R4 (UniProtKB/TrEMBL),   A0A8I3RTX9 (UniProtKB/TrEMBL),   A0A8C0LLM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022267884   ⟸   XM_022412176
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LNI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000015820   ⟸   ENSCAFT00000017097
RefSeq Acc Id: XP_038326344   ⟸   XM_038470416
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038326345   ⟸   XM_038470417
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038326343   ⟸   XM_038470415
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038326342   ⟸   XM_038470414
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038451408   ⟸   XM_038595480
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038451407   ⟸   XM_038595479
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038451406   ⟸   XM_038595478
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038515492   ⟸   XM_038659564
- Peptide Label: isoform X4
- UniProtKB: A0A8C0P0R4 (UniProtKB/TrEMBL),   A0A8I3RTX9 (UniProtKB/TrEMBL),   A0A8C0LLM0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515493   ⟸   XM_038659565
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LLM0 (UniProtKB/TrEMBL),   A0A8C0LNI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515491   ⟸   XM_038659563
- Peptide Label: isoform X3
- UniProtKB: A0A8C0LNI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515490   ⟸   XM_038659562
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LNI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387186   ⟸   XM_038531258
- Peptide Label: isoform X4
- UniProtKB: A0A8C0LLM0 (UniProtKB/TrEMBL),   A0A8C0P0R4 (UniProtKB/TrEMBL),   A0A8I3RTX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387185   ⟸   XM_038531257
- Peptide Label: isoform X3
- UniProtKB: A0A8C0LNI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387184   ⟸   XM_038531256
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LNI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007145   ⟸   ENSCAFT00845009060
Protein Domains
IBB

Promoters
RGD ID:13682551
Promoter ID:EPDNEW_C620
Type:initiation region
Name:KPNA6_1
Description:karyopherin subunit alpha 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1269,077,989 - 69,078,049EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010737 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017398 UniProtKB/TrEMBL
  ENSCAFG00040021552 UniProtKB/TrEMBL
  ENSCAFG00845005057 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017097.7 UniProtKB/TrEMBL
  ENSCAFT00030032143.1 UniProtKB/TrEMBL
  ENSCAFT00040040107.1 UniProtKB/TrEMBL
  ENSCAFT00845009060 ENTREZGENE
  ENSCAFT00845009060.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.690 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Importin-a_IBB UniProtKB/TrEMBL
  Importin-a_IBB_sf UniProtKB/TrEMBL
  Importin_alpha UniProtKB/TrEMBL
NCBI Gene KPNA6 ENTREZGENE
PANTHER IMPORTIN ALPHA UniProtKB/TrEMBL
  IMPORTIN SUBUNIT ALPHA-7 UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
PIRSF Importin_alpha UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A8C0LLM0 ENTREZGENE
  A0A8C0LNI3 ENTREZGENE
  A0A8C0P0R4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTX9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42504 ENTREZGENE