PTPRN2 (protein tyrosine phosphatase receptor type N2) - Rat Genome Database

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Gene: PTPRN2 (protein tyrosine phosphatase receptor type N2) Canis lupus familiaris
Analyze
Symbol: PTPRN2
Name: protein tyrosine phosphatase receptor type N2
RGD ID: 12231228
Description: ENCODES a protein that exhibits protein tyrosine phosphatase activity (inferred); INVOLVED IN negative regulation of GTPase activity (ortholog); neurotransmitter secretion (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); holoprosencephaly 3 (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog); presynapse (ortholog); receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor-type tyrosine-protein phosphatase N2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11619,904,468 - 20,562,585 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1619,905,473 - 20,602,680 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1620,472,150 - 21,134,670 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01621,636,514 - 22,361,137 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11620,003,354 - 20,728,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01620,586,565 - 21,312,677 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01620,639,115 - 21,366,802 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPRN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11619,904,468 - 20,562,585 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1619,905,473 - 20,602,680 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1620,472,150 - 21,134,670 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01621,636,514 - 22,361,137 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11620,003,354 - 20,728,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01620,586,565 - 21,312,677 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01620,639,115 - 21,366,802 (-)NCBIUU_Cfam_GSD_1.0
PTPRN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387157,539,056 - 158,587,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7157,539,056 - 158,587,823 (-)EnsemblGRCh38hg38GRCh38
GRCh377157,331,750 - 158,380,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367157,024,516 - 158,073,179 (-)NCBINCBI36Build 36hg18NCBI36
Build 347156,831,230 - 157,879,894NCBI
Celera7151,758,421 - 152,708,128 (-)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7151,062,797 - 152,022,430 (-)NCBIHuRef
CHM1_17157,340,603 - 158,388,873 (-)NCBICHM1_1
T2T-CHM13v2.07158,727,687 - 159,797,184 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27156,563,177 - 157,584,848 (-)NCBI
Ptprn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912116,449,316 - 117,241,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12116,449,340 - 117,240,469 (+)EnsemblGRCm39 Ensembl
GRCm3812116,485,695 - 117,278,167 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12116,485,720 - 117,276,849 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712117,724,193 - 118,516,640 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612110,685,719 - 111,477,358 (+)NCBIMGSCv36mm8
MGSCv3612116,927,842 - 117,718,802 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1262.65NCBI
Ptprn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86143,582,568 - 144,334,573 (+)NCBIGRCr8
mRatBN7.26137,439,572 - 138,191,575 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6137,439,540 - 138,191,575 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6140,874,866 - 141,626,022 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06137,499,335 - 138,243,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06138,047,241 - 138,799,129 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06144,384,773 - 145,133,042 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6144,384,773 - 145,133,042 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06153,312,968 - 154,056,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46143,787,884 - 144,549,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16143,794,070 - 144,555,221 (+)NCBI
Celera6135,102,182 - 135,845,915 (+)NCBICelera
Cytogenetic Map6q33NCBI
Ptprn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955579364,748 - 833,729 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955579366,441 - 862,837 (-)NCBIChiLan1.0ChiLan1.0
PTPRN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26193,988,298 - 195,067,961 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1745,998,563 - 47,078,226 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07149,158,513 - 150,390,077 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17160,850,042 - 161,756,328 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7160,851,703 - 161,756,325 (-)Ensemblpanpan1.1panPan2
Ptprn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118752,917 - 1,422,817 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493679755,217 - 151,201 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18721,131 - 1,389,607 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.118721,125 - 1,389,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2181,081,388 - 1,085,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121125,655,787 - 126,622,503 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607221,894,122 - 23,016,772 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624800648,264 - 1,117,312 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624800501,884 - 1,116,795 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTPRN2
12390 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 10 12 2
Low 5 12 6 5 6 1 8 6
Below cutoff 5 1 5 5 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000049020   ⟹   ENSCAFP00000041915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1619,905,473 - 20,512,457 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000079760   ⟹   ENSCAFP00000054939
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1619,905,899 - 20,602,680 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090217   ⟹   ENSCAFP00000057951
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1619,905,473 - 20,495,875 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000092966   ⟹   ENSCAFP00000054322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1619,905,473 - 20,562,585 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093900   ⟹   ENSCAFP00000044647
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1619,922,118 - 20,599,558 (-)Ensembl
RefSeq Acc Id: XM_038452201   ⟹   XP_038308129
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1620,472,150 - 21,134,670 (-)NCBI
RefSeq Acc Id: XM_038497416   ⟹   XP_038353344
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11620,003,354 - 20,728,392 (-)NCBI
RefSeq Acc Id: XM_038559842   ⟹   XP_038415770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01620,639,115 - 21,366,802 (-)NCBI
RefSeq Acc Id: XM_038559843   ⟹   XP_038415771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01620,639,115 - 21,221,312 (-)NCBI
RefSeq Acc Id: XM_038623856   ⟹   XP_038479784
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01620,586,565 - 21,312,677 (-)NCBI
RefSeq Acc Id: XM_038623857   ⟹   XP_038479785
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01620,586,565 - 21,167,016 (-)NCBI
RefSeq Acc Id: XM_038689622   ⟹   XP_038545550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01621,636,514 - 22,361,137 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000044647   ⟸   ENSCAFT00000093900
RefSeq Acc Id: ENSCAFP00000041915   ⟸   ENSCAFT00000049020
RefSeq Acc Id: ENSCAFP00000054322   ⟸   ENSCAFT00000092966
RefSeq Acc Id: ENSCAFP00000057951   ⟸   ENSCAFT00000090217
RefSeq Acc Id: ENSCAFP00000054939   ⟸   ENSCAFT00000079760
RefSeq Acc Id: XP_038353344   ⟸   XM_038497416
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038479784   ⟸   XM_038623856
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038479785   ⟸   XM_038623857
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038545550   ⟸   XM_038689622
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PMW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038308129   ⟸   XM_038452201
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038415770   ⟸   XM_038559842
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PMW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415771   ⟸   XM_038559843
- Peptide Label: isoform X3
- UniProtKB: A0A8C0PKB2 (UniProtKB/TrEMBL)
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032520 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023251 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000049020.3 UniProtKB/TrEMBL
  ENSCAFT00030042832.1 UniProtKB/TrEMBL
  ENSCAFT00030043453.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
  Protein-tyrosine phosphatase receptor IA-2 ectodomain UniProtKB/TrEMBL
InterPro IA-2/IA-2_beta UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  Receptor_IA-2_dom UniProtKB/TrEMBL
  Receptor_IA-2_ectodomain_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
NCBI Gene PTPRN2 ENTREZGENE
PANTHER PTHR46106 UniProtKB/TrEMBL
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 UniProtKB/TrEMBL
Pfam Receptor_IA-2 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  RESP18 UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A8C0PKB2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PMW0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SVI2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45194 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 PTPRN2  protein tyrosine phosphatase receptor type N2    protein tyrosine phosphatase, receptor type N2  Symbol and/or name change 5135510 APPROVED