HYAL2 (hyaluronidase 2) - Rat Genome Database

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Gene: HYAL2 (hyaluronidase 2) Canis lupus familiaris
Analyze
Symbol: HYAL2
Name: hyaluronidase 2
RGD ID: 12230726
Description: ENCODES a protein that exhibits enzyme binding (ortholog); hyaluronic acid binding (ortholog); hyaluronoglucuronidase activity (ortholog); INVOLVED IN cartilage development (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH Kidney Reperfusion Injury (ortholog); pulmonary hypertension (ortholog); FOUND IN anchored component of external side of plasma membrane (ortholog); anchored component of plasma membrane (ortholog); apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hyaluronidase-2; hyaluronoglucosaminidase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,029,426 - 39,034,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,031,735 - 39,034,130 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,950,366 - 38,955,492 (+)NCBI
ROS_Cfam_1.02039,385,361 - 39,390,488 (+)NCBI
UMICH_Zoey_3.12038,753,188 - 38,758,313 (+)NCBI
UNSW_CanFamBas_1.02039,156,748 - 39,161,868 (+)NCBI
UU_Cfam_GSD_1.02039,436,765 - 39,441,893 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
carbohydrate metabolic process  (IEA)
cartilage development  (ISS)
cellular response to fibroblast growth factor stimulus  (ISS)
cellular response to interleukin-1  (ISS)
cellular response to transforming growth factor beta stimulus  (ISS)
cellular response to tumor necrosis factor  (IEA)
cellular response to UV-B  (ISS)
defense response to virus  (IEA)
fusion of virus membrane with host plasma membrane  (ISS)
glycosaminoglycan catabolic process  (ISS)
hematopoietic progenitor cell differentiation  (IEA,ISO)
hyaluronan catabolic process  (IBA,ISS)
kidney development  (ISO)
monocyte activation  (ISS)
multicellular organism aging  (IEA,ISO)
multicellular organismal iron ion homeostasis  (IEA,ISO)
negative regulation of cell growth  (ISS)
negative regulation of fibroblast migration  (ISS)
negative regulation of MAP kinase activity  (ISS)
negative regulation of protein kinase B signaling  (ISS)
negative regulation of protein tyrosine kinase activity  (ISS)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of inflammatory response  (ISS)
positive regulation of interleukin-6 production  (ISS)
positive regulation of interleukin-8 production  (ISS)
positive regulation of protein import into nucleus  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of urine volume  (ISS)
renal water absorption  (ISS)
response to antibiotic  (IEA)
response to reactive oxygen species  (ISS)
response to virus  (ISS)
skeletal system morphogenesis  (IEA,ISO)
transformation of host cell by virus  (ISO,ISS)
viral entry into host cell  (ISO,ISS)

References

Genomics

Comparative Map Data
HYAL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,029,426 - 39,034,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,031,735 - 39,034,130 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,950,366 - 38,955,492 (+)NCBI
ROS_Cfam_1.02039,385,361 - 39,390,488 (+)NCBI
UMICH_Zoey_3.12038,753,188 - 38,758,313 (+)NCBI
UNSW_CanFamBas_1.02039,156,748 - 39,161,868 (+)NCBI
UU_Cfam_GSD_1.02039,436,765 - 39,441,893 (+)NCBI
HYAL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,317,790 - 50,322,782 (-)EnsemblGRCh38hg38GRCh38
GRCh38350,317,802 - 50,322,768 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,355,239 - 50,360,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,330,244 - 50,335,146 (-)NCBINCBI36hg18NCBI36
Build 34350,330,243 - 50,333,903NCBI
Celera350,328,056 - 50,333,116 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,410,935 - 50,415,994 (-)NCBIHuRef
CHM1_1350,307,488 - 50,312,547 (-)NCBICHM1_1
Hyal2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,445,085 - 107,449,977 (+)NCBIGRCm39mm39
GRCm39 Ensembl9107,445,144 - 107,449,978 (+)Ensembl
GRCm389107,567,873 - 107,572,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,567,945 - 107,572,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,471,494 - 107,475,109 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,427,264 - 107,430,879 (+)NCBImm8
Celera9107,177,912 - 107,181,527 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.12NCBI
Hyal2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,241,895 - 108,246,853 (+)NCBI
Rnor_6.0 Ensembl8116,324,040 - 116,328,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08116,324,062 - 116,328,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08115,680,309 - 115,685,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,817,001 - 112,820,693 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18112,836,484 - 112,840,147 (+)NCBI
Celera8107,549,728 - 107,586,609 (+)NCBICelera
Cytogenetic Map8q32NCBI
Hyal2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,120,781 - 2,123,726 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,120,781 - 2,125,083 (-)NCBIChiLan1.0ChiLan1.0
HYAL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,479,020 - 51,484,638 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,479,020 - 51,482,551 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,243,926 - 50,248,972 (-)NCBIMhudiblu_PPA_v0panPan3
Hyal2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,084,685 - 65,090,478 (-)NCBI
SpeTri2.0NW_0049365291,845,445 - 1,851,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HYAL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,805,223 - 32,815,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,805,220 - 32,813,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,983,753 - 35,988,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q21NCBI
HYAL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,704,422 - 11,710,013 (-)NCBI
ChlSab1.1 Ensembl2211,703,790 - 11,709,454 (-)Ensembl
Vero_WHO_p1.0NW_023666041155,277,024 - 155,282,088 (+)NCBI
Hyal2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,170,045 - 4,175,264 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 2 13 6 5 4 10 5
Low 4 3 9 6 6 1 6 8 8 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005632510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005632511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005632513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_541876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000016952   ⟹   ENSCAFP00000015681
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2039,031,735 - 39,034,130 (+)Ensembl
RefSeq Acc Id: XM_005632510   ⟹   XP_005632567
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,030,730 - 39,034,451 (+)NCBI
Dog10K_Boxer_Tasha2038,951,782 - 38,955,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005632511   ⟹   XP_005632568
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,031,048 - 39,034,451 (+)NCBI
Dog10K_Boxer_Tasha2038,952,054 - 38,955,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005632513   ⟹   XP_005632570
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,029,426 - 39,034,451 (+)NCBI
Dog10K_Boxer_Tasha2038,950,366 - 38,955,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038427686   ⟹   XP_038283614
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02039,385,524 - 39,390,488 (+)NCBI
RefSeq Acc Id: XM_038427688   ⟹   XP_038283616
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02039,386,777 - 39,390,488 (+)NCBI
RefSeq Acc Id: XM_038427689   ⟹   XP_038283617
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02039,387,050 - 39,390,488 (+)NCBI
RefSeq Acc Id: XM_038427690   ⟹   XP_038283618
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02039,385,361 - 39,390,488 (+)NCBI
RefSeq Acc Id: XM_038427691   ⟹   XP_038283619
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02039,387,036 - 39,390,488 (+)NCBI
RefSeq Acc Id: XM_038455223   ⟹   XP_038311151
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2038,952,040 - 38,955,492 (+)NCBI
RefSeq Acc Id: XM_038503373   ⟹   XP_038359301
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12038,753,351 - 38,758,313 (+)NCBI
RefSeq Acc Id: XM_038503374   ⟹   XP_038359302
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12038,754,604 - 38,758,313 (+)NCBI
RefSeq Acc Id: XM_038503375   ⟹   XP_038359303
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12038,754,875 - 38,758,313 (+)NCBI
RefSeq Acc Id: XM_038503376   ⟹   XP_038359304
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12038,753,188 - 38,758,313 (+)NCBI
RefSeq Acc Id: XM_038503377   ⟹   XP_038359305
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12038,754,861 - 38,758,313 (+)NCBI
RefSeq Acc Id: XM_038566374   ⟹   XP_038422302
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02039,436,928 - 39,441,893 (+)NCBI
RefSeq Acc Id: XM_038566375   ⟹   XP_038422303
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02039,438,181 - 39,441,893 (+)NCBI
RefSeq Acc Id: XM_038566376   ⟹   XP_038422304
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02039,438,455 - 39,441,893 (+)NCBI
RefSeq Acc Id: XM_038566377   ⟹   XP_038422305
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02039,436,765 - 39,441,893 (+)NCBI
RefSeq Acc Id: XM_038566378   ⟹   XP_038422306
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02039,438,441 - 39,441,893 (+)NCBI
RefSeq Acc Id: XM_038630524   ⟹   XP_038486452
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02039,156,911 - 39,161,868 (+)NCBI
RefSeq Acc Id: XM_038630525   ⟹   XP_038486453
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02039,158,164 - 39,161,868 (+)NCBI
RefSeq Acc Id: XM_038630526   ⟹   XP_038486454
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02039,158,433 - 39,161,868 (+)NCBI
RefSeq Acc Id: XM_038630527   ⟹   XP_038486455
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02039,156,748 - 39,161,868 (+)NCBI
RefSeq Acc Id: XM_038630528   ⟹   XP_038486456
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02039,158,419 - 39,161,868 (+)NCBI
RefSeq Acc Id: XM_541876   ⟹   XP_541876
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,029,485 - 39,034,451 (+)NCBI
Dog10K_Boxer_Tasha2038,950,529 - 38,955,492 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005632570   ⟸   XM_005632513
- Sequence:
RefSeq Acc Id: XP_541876   ⟸   XM_541876
- Sequence:
RefSeq Acc Id: XP_005632567   ⟸   XM_005632510
- Sequence:
RefSeq Acc Id: XP_005632568   ⟸   XM_005632511
- Sequence:
RefSeq Acc Id: ENSCAFP00000015681   ⟸   ENSCAFT00000016952
RefSeq Acc Id: XP_038359304   ⟸   XM_038503376
RefSeq Acc Id: XP_038359301   ⟸   XM_038503373
RefSeq Acc Id: XP_038359302   ⟸   XM_038503374
RefSeq Acc Id: XP_038359305   ⟸   XM_038503377
RefSeq Acc Id: XP_038359303   ⟸   XM_038503375
RefSeq Acc Id: XP_038486455   ⟸   XM_038630527
RefSeq Acc Id: XP_038486452   ⟸   XM_038630524
RefSeq Acc Id: XP_038486453   ⟸   XM_038630525
RefSeq Acc Id: XP_038486456   ⟸   XM_038630528
RefSeq Acc Id: XP_038486454   ⟸   XM_038630526
RefSeq Acc Id: XP_038283618   ⟸   XM_038427690
RefSeq Acc Id: XP_038283614   ⟸   XM_038427686
RefSeq Acc Id: XP_038283616   ⟸   XM_038427688
RefSeq Acc Id: XP_038283619   ⟸   XM_038427691
RefSeq Acc Id: XP_038283617   ⟸   XM_038427689
RefSeq Acc Id: XP_038311151   ⟸   XM_038455223
RefSeq Acc Id: XP_038422305   ⟸   XM_038566377
RefSeq Acc Id: XP_038422302   ⟸   XM_038566374
RefSeq Acc Id: XP_038422303   ⟸   XM_038566375
RefSeq Acc Id: XP_038422306   ⟸   XM_038566378
RefSeq Acc Id: XP_038422304   ⟸   XM_038566376


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010657 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000015681 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016952 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
  Hyaluronidase UniProtKB/TrEMBL
KEGG Report cfa:484760 UniProtKB/TrEMBL
NCBI Gene HYAL2 ENTREZGENE
PANTHER PTHR11769 UniProtKB/TrEMBL
Pfam Glyco_hydro_56 UniProtKB/TrEMBL
PIRSF Hyaluronidase UniProtKB/TrEMBL
PRINTS GLHYDRLASE56 UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt E2R560_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41843 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-07 HYAL2  hyaluronidase 2    hyaluronoglucosaminidase 2  Symbol and/or name change 5135510 APPROVED