MED20 (mediator complex subunit 20) - Rat Genome Database

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Gene: MED20 (mediator complex subunit 20) Canis lupus familiaris
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Symbol: MED20
Name: mediator complex subunit 20
RGD ID: 12230698
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); skeletal muscle cell differentiation (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH genetic disease (ortholog); infantile Refsum disease (ortholog); Zellweger syndrome (ortholog); FOUND IN core mediator complex (ortholog); ubiquitin ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mediator of RNA polymerase II transcription subunit 20; Trf (TATA binding protein-related factor)-proximal homolog; TRFP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11210,569,051 - 10,580,809 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1210,570,664 - 10,580,675 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1210,599,583 - 10,610,144 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01211,050,985 - 11,061,544 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1211,049,797 - 11,061,502 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,581,040 - 10,591,572 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,665,010 - 10,675,547 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,758,924 - 10,769,469 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MED20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11210,569,051 - 10,580,809 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1210,570,664 - 10,580,675 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1210,599,583 - 10,610,144 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01211,050,985 - 11,061,544 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1211,049,797 - 11,061,502 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,581,040 - 10,591,572 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,665,010 - 10,675,547 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,758,924 - 10,769,469 (-)NCBIUU_Cfam_GSD_1.0
MED20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,905,354 - 41,921,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,905,354 - 41,921,139 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,873,092 - 41,888,877 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,981,070 - 41,996,855 (-)NCBINCBI36Build 36hg18NCBI36
Celera643,425,870 - 43,441,669 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef641,591,868 - 41,607,667 (-)NCBIHuRef
CHM1_1641,875,832 - 41,891,635 (-)NCBICHM1_1
T2T-CHM13v2.0641,733,914 - 41,749,699 (-)NCBIT2T-CHM13v2.0
Med20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,922,510 - 47,935,176 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,922,507 - 47,935,343 (+)EnsemblGRCm39 Ensembl
GRCm381747,611,585 - 47,624,251 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,611,582 - 47,624,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv371747,748,545 - 47,761,367 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,074,787 - 47,087,609 (+)NCBIMGSCv36mm8
Celera1751,048,559 - 51,061,383 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.66NCBI
Med20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,867,681 - 20,880,288 (-)NCBIGRCr8
mRatBN7.2913,370,146 - 13,382,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,370,146 - 13,382,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,949,914 - 21,962,232 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,014,071 - 27,026,357 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,313,319 - 25,325,633 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,379,379 - 15,393,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,379,385 - 15,393,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,303,681 - 14,314,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,836,460 - 8,839,869 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.198,837,747 - 8,849,132 (-)NCBI
Celera911,121,565 - 11,133,698 (-)NCBICelera
Cytogenetic Map9q12NCBI
Med20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,246,335 - 8,256,986 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,246,335 - 8,256,987 (-)NCBIChiLan1.0ChiLan1.0
MED20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2556,396,924 - 56,412,417 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,266,855 - 52,282,327 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,489,079 - 41,504,572 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,790,975 - 42,806,538 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,790,975 - 42,806,538 (-)Ensemblpanpan1.1panPan2
Med20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494646,043,639 - 46,160,543 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,895,954 - 17,912,835 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,896,689 - 17,976,102 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl737,058,131 - 37,074,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1737,062,555 - 37,074,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,467,420 - 42,476,335 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MED20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,241,772 - 30,256,867 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,247,752 - 30,255,127 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,904,250 - 41,921,025 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,204,841 - 17,221,480 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,204,913 - 17,218,993 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MED20
150 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 5 22 6 6 6 6 6 12 6 10 6
Below cutoff 2

Sequence


RefSeq Acc Id: ENSCAFT00000002529   ⟹   ENSCAFP00000002348
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1210,570,664 - 10,580,675 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845028349   ⟹   ENSCAFP00845022301
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1211,049,797 - 11,061,502 (-)Ensembl
RefSeq Acc Id: XM_014118436   ⟹   XP_013973911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11210,569,051 - 10,580,809 (-)NCBI
Dog10K_Boxer_Tasha1210,599,583 - 10,610,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038491807   ⟹   XP_038347735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11210,581,040 - 10,591,572 (-)NCBI
RefSeq Acc Id: XM_038554044   ⟹   XP_038409972
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01210,758,924 - 10,769,469 (-)NCBI
RefSeq Acc Id: XM_038617905   ⟹   XP_038473833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01210,665,010 - 10,675,547 (-)NCBI
RefSeq Acc Id: XM_038683504   ⟹   XP_038539432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01211,050,985 - 11,061,544 (-)NCBI
RefSeq Acc Id: XP_013973911   ⟸   XM_014118436
- UniProtKB: A0A8C0K5I5 (UniProtKB/TrEMBL),   A0A8C0MMY1 (UniProtKB/TrEMBL),   A0A8I3NP31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000002348   ⟸   ENSCAFT00000002529
RefSeq Acc Id: XP_038347735   ⟸   XM_038491807
RefSeq Acc Id: XP_038473833   ⟸   XM_038617905
RefSeq Acc Id: XP_038539432   ⟸   XM_038683504
- UniProtKB: A0A8C0K5I5 (UniProtKB/TrEMBL),   A0A8C0MMY1 (UniProtKB/TrEMBL),   A0A8I3NP31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038409972   ⟸   XM_038554044
- UniProtKB: A0A8C0K5I5 (UniProtKB/TrEMBL),   A0A8C0MMY1 (UniProtKB/TrEMBL),   A0A8I3NP31 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845022301   ⟸   ENSCAFT00845028349


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001613 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005763 UniProtKB/TrEMBL
  ENSCAFG00040005356 UniProtKB/TrEMBL
  ENSCAFG00845015923 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002529.4 UniProtKB/TrEMBL
  ENSCAFT00030010579.1 UniProtKB/TrEMBL
  ENSCAFT00040010068.1 UniProtKB/TrEMBL
  ENSCAFT00845028349 ENTREZGENE
  ENSCAFT00845028349.1 UniProtKB/TrEMBL
InterPro Mediator_Med20 UniProtKB/TrEMBL
KEGG Report cfa:481796 UniProtKB/TrEMBL
NCBI Gene MED20 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20 UniProtKB/TrEMBL
  PTHR12465 UniProtKB/TrEMBL
Pfam Med20 UniProtKB/TrEMBL
UniProt A0A8C0K5I5 ENTREZGENE
  A0A8C0MMY1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NP31 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43129 ENTREZGENE