KIF5B (kinesin family member 5B) - Rat Genome Database

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Gene: KIF5B (kinesin family member 5B) Canis lupus familiaris
Analyze
Symbol: KIF5B
Name: kinesin family member 5B
RGD ID: 12227151
Description: ENCODES a protein that exhibits JUN kinase binding (ortholog); microtubule lateral binding (ortholog); INVOLVED IN anterograde axonal protein transport (ortholog); cellular response to type II interferon (ortholog); cytoplasm organization (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mitochondria transport pathway; N-cadherin signaling pathway; ASSOCIATED WITH Developmental Disabilities (ortholog); diabetes mellitus (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN axonal growth cone (ortholog); microtubule cytoskeleton (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH mocetinostat
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kinesin-1 heavy chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1214,835,906 - 14,880,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl214,835,901 - 14,878,251 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha212,323,571 - 12,368,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0213,072,118 - 13,117,087 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl213,072,118 - 13,116,722 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1212,512,247 - 12,557,211 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0212,403,006 - 12,447,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0212,676,797 - 12,721,749 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
mocetinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:26002460   PMID:30032202  


Genomics

Comparative Map Data
KIF5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1214,835,906 - 14,880,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl214,835,901 - 14,878,251 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha212,323,571 - 12,368,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0213,072,118 - 13,117,087 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl213,072,118 - 13,116,722 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1212,512,247 - 12,557,211 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0212,403,006 - 12,447,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0212,676,797 - 12,721,749 (+)NCBIUU_Cfam_GSD_1.0
KIF5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381032,009,015 - 32,056,425 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1032,009,015 - 32,056,425 (-)EnsemblGRCh38hg38GRCh38
GRCh371032,297,943 - 32,345,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361032,340,077 - 32,385,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 341032,340,076 - 32,385,221NCBI
Celera1032,062,826 - 32,110,627 (-)NCBICelera
Cytogenetic Map10p11.22NCBI
HuRef1032,018,111 - 32,065,919 (-)NCBIHuRef
CHM1_11032,299,660 - 32,347,071 (-)NCBICHM1_1
T2T-CHM13v2.01032,037,647 - 32,085,426 (-)NCBIT2T-CHM13v2.0
Kif5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,201,005 - 6,241,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,201,002 - 6,242,174 (-)EnsemblGRCm39 Ensembl
GRCm38186,201,005 - 6,241,524 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,201,002 - 6,242,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv37186,201,003 - 6,241,522 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36186,202,209 - 6,241,498 (-)NCBIMGSCv36mm8
Celera186,247,889 - 6,288,660 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.46NCBI
Kif5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81756,185,386 - 56,222,990 (+)NCBIGRCr8
mRatBN7.21751,489,904 - 51,527,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1751,489,944 - 51,527,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1754,663,892 - 54,694,120 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01758,666,828 - 58,697,056 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01752,804,979 - 52,835,181 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01754,181,416 - 54,219,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,181,419 - 54,212,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01751,875,803 - 51,913,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41759,697,082 - 59,727,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11759,728,937 - 59,735,497 (+)NCBI
Celera1747,501,097 - 47,531,289 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
Kif5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542923,631,282 - 23,678,562 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542923,632,246 - 23,678,797 (-)NCBIChiLan1.0ChiLan1.0
KIF5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2844,659,162 - 44,706,677 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11044,664,488 - 44,712,585 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01032,138,964 - 32,186,448 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11032,731,150 - 32,778,242 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1032,731,150 - 32,778,242 (-)Ensemblpanpan1.1panPan2
Kif5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934411,280,577 - 11,324,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936574779,777 - 823,970 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936574780,074 - 823,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1042,637,109 - 42,693,491 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11042,637,105 - 42,693,551 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21047,233,047 - 47,293,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIF5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1931,321,615 - 31,369,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl931,320,549 - 31,369,519 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605640,295,395 - 40,343,097 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248054,465,235 - 4,514,870 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248054,464,538 - 4,514,784 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KIF5B
497 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 15 6 6 6 12 8 10 6
Low 7 6 6
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000006549   ⟹   ENSCAFP00000006062
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl214,835,901 - 14,878,251 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000069826   ⟹   ENSCAFP00000064829
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl214,835,901 - 14,874,361 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845017378   ⟹   ENSCAFP00845013532
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl213,072,118 - 13,115,984 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845017547   ⟹   ENSCAFP00845013657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl213,072,187 - 13,116,722 (+)Ensembl
RefSeq Acc Id: XM_003638878   ⟹   XP_003638926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1214,835,906 - 14,880,896 (+)NCBI
Dog10K_Boxer_Tasha212,323,571 - 12,368,548 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038469163   ⟹   XP_038325091
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1212,512,247 - 12,557,211 (+)NCBI
RefSeq Acc Id: XM_038529873   ⟹   XP_038385801
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0212,676,797 - 12,721,749 (+)NCBI
RefSeq Acc Id: XM_038594125   ⟹   XP_038450053
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0212,403,006 - 12,447,970 (+)NCBI
RefSeq Acc Id: XM_038658193   ⟹   XP_038514121
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0213,072,118 - 13,117,087 (+)NCBI
RefSeq Acc Id: XR_005355202
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0212,676,797 - 12,721,749 (+)NCBI
RefSeq Acc Id: XP_003638926   ⟸   XM_003638878
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NXA2 (UniProtKB/TrEMBL),   A0A8I3N413 (UniProtKB/TrEMBL),   A0A8C0Q0Q3 (UniProtKB/TrEMBL),   A0A8I3NBU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000064829   ⟸   ENSCAFT00000069826
RefSeq Acc Id: ENSCAFP00000006062   ⟸   ENSCAFT00000006549
RefSeq Acc Id: XP_038325091   ⟸   XM_038469163
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038450053   ⟸   XM_038594125
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038514121   ⟸   XM_038658193
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NXA2 (UniProtKB/TrEMBL),   A0A8I3N413 (UniProtKB/TrEMBL),   A0A8C0Q0Q3 (UniProtKB/TrEMBL),   A0A8I3NBU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038385801   ⟸   XM_038529873
- Peptide Label: isoform X2
- UniProtKB: A0A8C0Q0Q3 (UniProtKB/TrEMBL),   A0A8I3NBU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845013532   ⟸   ENSCAFT00845017378
RefSeq Acc Id: ENSCAFP00845013657   ⟸   ENSCAFT00845017547
Protein Domains
Kinesin motor

Promoters
RGD ID:13682389
Promoter ID:EPDNEW_C459
Type:initiation region
Name:KIF5B_1
Description:kinesin family member 5B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1214,835,931 - 14,835,991EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004076 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021003 UniProtKB/TrEMBL
  ENSCAFG00040000106 UniProtKB/TrEMBL
  ENSCAFG00845009863 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006549.5 UniProtKB/TrEMBL
  ENSCAFT00000069826.2 UniProtKB/TrEMBL
  ENSCAFT00030038595.1 UniProtKB/TrEMBL
  ENSCAFT00030038744.1 UniProtKB/TrEMBL
  ENSCAFT00040000158.1 UniProtKB/TrEMBL
  ENSCAFT00040000196.1 UniProtKB/TrEMBL
  ENSCAFT00845017378.1 UniProtKB/TrEMBL
  ENSCAFT00845017547 ENTREZGENE
  ENSCAFT00845017547.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.10.250.1590 UniProtKB/TrEMBL
InterPro Kinesin-like_fam UniProtKB/TrEMBL
  Kinesin_motor_CS UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:100855651 UniProtKB/TrEMBL
NCBI Gene KIF5B ENTREZGENE
PANTHER CENTROMERE PROTEIN E UniProtKB/TrEMBL
  KINESIN-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Kinesin UniProtKB/TrEMBL
PRINTS KINESINHEAVY UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_1 UniProtKB/TrEMBL
  KINESIN_MOTOR_2 UniProtKB/TrEMBL
SMART KISc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0NXA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q0Q3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N413 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NBU4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42408 ENTREZGENE