NHP2 (NHP2 ribonucleoprotein) - Rat Genome Database

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Gene: NHP2 (NHP2 ribonucleoprotein) Canis lupus familiaris
Analyze
Symbol: NHP2
Name: NHP2 ribonucleoprotein
RGD ID: 12224799
Description: ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); U3 snoRNA binding (ortholog); INVOLVED IN positive regulation of telomerase RNA localization to Cajal body (ortholog); snoRNA guided rRNA pseudouridine synthesis (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita (ortholog); autosomal recessive dyskeratosis congenita 1 (ortholog); autosomal recessive dyskeratosis congenita 2 (ortholog); FOUND IN box H/ACA snoRNP complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: H/ACA ribonucleoprotein complex subunit 2; NHP2 ribonucleoprotein homolog; NOLA2; nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,389,549 - 3,393,010 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,389,591 - 3,395,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha113,532,480 - 3,535,984 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,365,217 - 3,368,723 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,365,309 - 3,368,720 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,335,883 - 3,337,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,413,347 - 3,416,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,654,898 - 3,659,015 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NHP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,389,549 - 3,393,010 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,389,591 - 3,395,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha113,532,480 - 3,535,984 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,365,217 - 3,368,723 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,365,309 - 3,368,720 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,335,883 - 3,337,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,413,347 - 3,416,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,654,898 - 3,659,015 (+)NCBIUU_Cfam_GSD_1.0
NHP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385178,149,463 - 178,153,885 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5178,149,463 - 178,153,894 (-)EnsemblGRCh38hg38GRCh38
GRCh375177,576,464 - 177,580,886 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365177,509,070 - 177,513,567 (-)NCBINCBI36Build 36hg18NCBI36
Build 345177,509,073 - 177,513,567NCBI
Celera5173,203,446 - 173,207,943 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5172,302,433 - 172,306,930 (-)NCBIHuRef
CHM1_15177,007,842 - 177,012,339 (-)NCBICHM1_1
T2T-CHM13v2.05178,699,722 - 178,704,144 (-)NCBIT2T-CHM13v2.0
Nhp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,510,600 - 51,514,545 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,510,562 - 51,514,541 (+)EnsemblGRCm39 Ensembl
GRCm381151,619,773 - 51,623,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,619,735 - 51,623,714 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,433,275 - 51,437,216 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,463,196 - 51,467,137 (+)NCBIMGSCv36mm8
Celera1156,191,112 - 56,195,057 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.14NCBI
Nhp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,378,020 - 36,381,362 (+)NCBIGRCr8
mRatBN7.21035,877,057 - 35,880,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,877,054 - 35,882,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx363,415,455 - 63,415,690 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0371,999,106 - 71,999,341 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.01034,975,701 - 34,979,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,975,708 - 34,979,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,069,344 - 37,072,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,841,672 - 36,845,050 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,137,277 - 37,140,651 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1035,233,774 - 35,237,148 (+)NCBICelera
Cytogenetic Map10q22NCBI
Nhp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,090,772 - 2,094,453 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,090,772 - 2,094,453 (+)NCBIChiLan1.0ChiLan1.0
NHP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24173,090,862 - 173,095,371 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15171,230,398 - 171,234,909 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05173,308,560 - 173,313,046 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15180,566,008 - 180,570,502 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5180,566,008 - 180,570,502 (-)Ensemblpanpan1.1panPan2
Nhp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213113,517,778 - 113,522,464 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936647520,494 - 525,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936647520,542 - 525,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1280,223,439 - 80,227,614 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2281,839,915 - 81,844,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NHP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,842,690 - 79,847,138 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,842,948 - 79,846,984 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607511,143,336 - 11,147,779 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nhp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473341,371,897 - 41,375,363 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473341,371,897 - 41,375,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NHP2
43 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000376   ⟹   ENSCAFP00000000342
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl113,389,598 - 3,393,007 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000076652   ⟹   ENSCAFP00000063376
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl113,389,591 - 3,395,313 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845017685   ⟹   ENSCAFP00845013770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl113,365,309 - 3,368,720 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845017721   ⟹   ENSCAFP00845013801
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl113,365,317 - 3,368,672 (+)Ensembl
RefSeq Acc Id: XM_022425120   ⟹   XP_022280828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1113,389,554 - 3,393,010 (+)NCBI
Dog10K_Boxer_Tasha113,532,485 - 3,535,984 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022425121   ⟹   XP_022280829
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1113,389,549 - 3,393,010 (+)NCBI
Dog10K_Boxer_Tasha113,532,480 - 3,535,984 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038489775   ⟹   XP_038345703
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1113,335,883 - 3,337,251 (+)NCBI
RefSeq Acc Id: XM_038551815   ⟹   XP_038407743
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0113,654,898 - 3,659,015 (+)NCBI
RefSeq Acc Id: XM_038551816   ⟹   XP_038407744
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0113,655,511 - 3,659,015 (+)NCBI
RefSeq Acc Id: XM_038615704   ⟹   XP_038471632
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0113,413,352 - 3,416,848 (+)NCBI
RefSeq Acc Id: XM_038615705   ⟹   XP_038471633
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0113,413,347 - 3,416,848 (+)NCBI
RefSeq Acc Id: XM_038681172   ⟹   XP_038537100
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0113,365,222 - 3,368,723 (+)NCBI
RefSeq Acc Id: XM_038681173   ⟹   XP_038537101
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0113,365,217 - 3,368,723 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022280829   ⟸   XM_022425121
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NCD6 (UniProtKB/TrEMBL),   A0A8P0TQH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022280828   ⟸   XM_022425120
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NQ03 (UniProtKB/TrEMBL),   A0A8P0N3H9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000342   ⟸   ENSCAFT00000000376
RefSeq Acc Id: ENSCAFP00000063376   ⟸   ENSCAFT00000076652
RefSeq Acc Id: XP_038345703   ⟸   XM_038489775
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038471633   ⟸   XM_038615705
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038471632   ⟸   XM_038615704
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038537101   ⟸   XM_038681173
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NCD6 (UniProtKB/TrEMBL),   A0A8P0TQH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038537100   ⟸   XM_038681172
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NQ03 (UniProtKB/TrEMBL),   A0A8P0N3H9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407743   ⟸   XM_038551815
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NQ03 (UniProtKB/TrEMBL),   A0A8P0N3H9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407744   ⟸   XM_038551816
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NCD6 (UniProtKB/TrEMBL),   A0A8P0TQH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845013801   ⟸   ENSCAFT00845017721
RefSeq Acc Id: ENSCAFP00845013770   ⟸   ENSCAFT00845017685
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Promoters
RGD ID:13685133
Promoter ID:EPDNEW_C3202
Type:initiation region
Name:NHP2_1
Description:NHP2 ribonucleoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1113,389,589 - 3,389,649EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000240 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845010060 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000376.5 UniProtKB/TrEMBL
  ENSCAFT00000100492.1 UniProtKB/TrEMBL
  ENSCAFT00845017685 ENTREZGENE
  ENSCAFT00845017685.1 UniProtKB/TrEMBL
  ENSCAFT00845017721 ENTREZGENE
  ENSCAFT00845017721.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
InterPro H/ACA_rnp_Nhp2-like UniProtKB/TrEMBL
  L30e-like UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
  Ribosomal_L7Ae/L8/Nhp2 UniProtKB/TrEMBL
NCBI Gene NHP2 ENTREZGENE
PANTHER H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN L7AE FAMILY MEMBER UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
PRINTS L7ARS6FAMILY UniProtKB/TrEMBL
  NUCLEARHMG UniProtKB/TrEMBL
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt A0A8I3NCD6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NQ03 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N3H9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TQH1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43803 ENTREZGENE