APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) - Rat Genome Database

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Gene: APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Canis lupus familiaris
Analyze
Symbol: APPL2
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
RGD ID: 12223836
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN adiponectin-activated signaling pathway (inferred); cellular response to hepatocyte growth factor stimulus (inferred); cold acclimation (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); substance-related disorder (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic vesicle (ortholog); early phagosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: amyloid beta (A4) precursor-like protein 2; DCC-interacting protein 13-beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,192,261 - 33,243,034 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,191,602 - 33,242,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,111,933 - 33,162,406 (+)NCBI
ROS_Cfam_1.01034,033,756 - 34,084,221 (+)NCBI
UMICH_Zoey_3.11033,769,093 - 33,819,698 (+)NCBI
UNSW_CanFamBas_1.01034,053,225 - 34,103,854 (+)NCBI
UU_Cfam_GSD_1.01034,246,325 - 34,297,170 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
APPL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,192,261 - 33,243,034 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,191,602 - 33,242,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,111,933 - 33,162,406 (+)NCBI
ROS_Cfam_1.01034,033,756 - 34,084,221 (+)NCBI
UMICH_Zoey_3.11033,769,093 - 33,819,698 (+)NCBI
UNSW_CanFamBas_1.01034,053,225 - 34,103,854 (+)NCBI
UU_Cfam_GSD_1.01034,246,325 - 34,297,170 (+)NCBI
APPL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12105,173,297 - 105,236,203 (-)EnsemblGRCh38hg38GRCh38
GRCh3812105,173,297 - 105,236,174 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712105,567,078 - 105,629,952 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,091,205 - 104,154,138 (-)NCBINCBI36hg18NCBI36
Celera12105,231,366 - 105,294,273 (-)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12102,626,453 - 102,689,404 (-)NCBIHuRef
CHM1_112105,532,775 - 105,595,738 (-)NCBICHM1_1
Appl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391083,435,897 - 83,484,741 (-)NCBIGRCm39mm39
GRCm39 Ensembl1083,435,897 - 83,484,602 (-)Ensembl
GRCm381083,600,033 - 83,648,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1083,600,033 - 83,648,738 (-)EnsemblGRCm38mm10GRCm38
MGSCv371083,062,778 - 83,111,409 (-)NCBIGRCm37mm9NCBIm37
MGSCv361083,029,832 - 83,078,463 (-)NCBImm8
Celera1085,587,519 - 85,636,067 (-)NCBICelera
Cytogenetic Map10C1NCBI
Appl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2720,135,248 - 20,184,757 (+)NCBI
Rnor_6.0 Ensembl726,256,459 - 26,306,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0726,256,179 - 26,306,128 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0726,387,115 - 26,436,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4722,279,273 - 22,328,427 (+)NCBIRGSC3.4rn4RGSC3.4
Celera717,339,053 - 17,386,872 (+)NCBICelera
Cytogenetic Map7q13NCBI
Appl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540539,503,020 - 39,540,335 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540539,503,020 - 39,540,069 (-)NCBIChiLan1.0ChiLan1.0
APPL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112106,150,955 - 106,214,038 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12106,151,969 - 106,206,879 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012102,755,388 - 102,818,686 (-)NCBIMhudiblu_PPA_v0panPan3
Appl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494516,467,066 - 16,530,048 (+)NCBI
SpeTri2.0NW_0049364929,477,483 - 9,526,692 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APPL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl579,356,047 - 79,412,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1579,356,046 - 79,412,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2582,650,763 - 82,706,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q2.3NCBI
APPL2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111100,400,093 - 100,469,234 (-)NCBI
ChlSab1.1 Ensembl11100,400,084 - 100,462,507 (-)Ensembl
Vero_WHO_p1.0NW_023666037144,551,093 - 144,614,465 (+)NCBI
Appl2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247503,789,015 - 3,827,079 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 19 5 6 5 6 12 8 10 6
Low 3 1 1 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005625955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005625956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_538418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000002989   ⟹   ENSCAFP00000002772
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1033,199,006 - 33,242,290 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000069988   ⟹   ENSCAFP00000059188
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1033,191,602 - 33,242,669 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000076358   ⟹   ENSCAFP00000051353
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1033,195,004 - 33,242,290 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080274   ⟹   ENSCAFP00000061729
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1033,191,602 - 33,242,290 (+)Ensembl
RefSeq Acc Id: XM_005625955   ⟹   XP_005626012
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11033,192,264 - 33,243,034 (+)NCBI
Dog10K_Boxer_Tasha1033,111,935 - 33,162,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005625956   ⟹   XP_005626013
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11033,195,017 - 33,243,034 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022424522   ⟹   XP_022280230
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11033,192,263 - 33,243,034 (+)NCBI
Dog10K_Boxer_Tasha1033,111,935 - 33,162,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022424523   ⟹   XP_022280231
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11033,192,261 - 33,235,070 (+)NCBI
Dog10K_Boxer_Tasha1033,111,933 - 33,154,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038488841   ⟹   XP_038344769
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11033,769,095 - 33,819,698 (+)NCBI
RefSeq Acc Id: XM_038488842   ⟹   XP_038344770
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11033,769,095 - 33,819,698 (+)NCBI
RefSeq Acc Id: XM_038488843   ⟹   XP_038344771
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11033,769,095 - 33,819,698 (+)NCBI
RefSeq Acc Id: XM_038488844   ⟹   XP_038344772
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11033,769,093 - 33,811,952 (+)NCBI
RefSeq Acc Id: XM_038550805   ⟹   XP_038406733
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01034,246,327 - 34,297,170 (+)NCBI
RefSeq Acc Id: XM_038550806   ⟹   XP_038406734
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01034,246,327 - 34,297,170 (+)NCBI
RefSeq Acc Id: XM_038550807   ⟹   XP_038406735
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01034,246,327 - 34,297,170 (+)NCBI
RefSeq Acc Id: XM_038550808   ⟹   XP_038406736
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01034,246,325 - 34,289,185 (+)NCBI
RefSeq Acc Id: XM_038614725   ⟹   XP_038470653
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01034,053,227 - 34,103,854 (+)NCBI
RefSeq Acc Id: XM_038614726   ⟹   XP_038470654
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01034,053,227 - 34,103,854 (+)NCBI
RefSeq Acc Id: XM_038614727   ⟹   XP_038470655
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01034,053,227 - 34,103,854 (+)NCBI
RefSeq Acc Id: XM_038614728   ⟹   XP_038470656
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01034,053,225 - 34,096,108 (+)NCBI
RefSeq Acc Id: XM_038680093   ⟹   XP_038536021
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01034,033,758 - 34,084,221 (+)NCBI
RefSeq Acc Id: XM_038680094   ⟹   XP_038536022
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01034,033,758 - 34,084,221 (+)NCBI
RefSeq Acc Id: XM_038680095   ⟹   XP_038536023
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01034,033,758 - 34,084,221 (+)NCBI
RefSeq Acc Id: XM_038680096   ⟹   XP_038536024
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01034,033,756 - 34,076,475 (+)NCBI
RefSeq Acc Id: XM_538418   ⟹   XP_538418
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11033,192,264 - 33,243,034 (+)NCBI
Dog10K_Boxer_Tasha1033,111,935 - 33,162,406 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_538418   ⟸   XM_538418
- Peptide Label: isoform X1
- UniProtKB: E2RGZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005626012   ⟸   XM_005625955
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005626013   ⟸   XM_005625956
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022280231   ⟸   XM_022424523
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_022280230   ⟸   XM_022424522
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000059188   ⟸   ENSCAFT00000069988
RefSeq Acc Id: ENSCAFP00000061729   ⟸   ENSCAFT00000080274
RefSeq Acc Id: ENSCAFP00000051353   ⟸   ENSCAFT00000076358
RefSeq Acc Id: ENSCAFP00000002772   ⟸   ENSCAFT00000002989
RefSeq Acc Id: XP_038344772   ⟸   XM_038488844
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038344769   ⟸   XM_038488841
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038344770   ⟸   XM_038488842
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038344771   ⟸   XM_038488843
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038470656   ⟸   XM_038614728
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038470653   ⟸   XM_038614725
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470654   ⟸   XM_038614726
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038470655   ⟸   XM_038614727
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038536024   ⟸   XM_038680096
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038536021   ⟸   XM_038680093
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038536022   ⟸   XM_038680094
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038536023   ⟸   XM_038680095
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038406736   ⟸   XM_038550808
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038406733   ⟸   XM_038550805
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038406734   ⟸   XM_038550806
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038406735   ⟸   XM_038550807
- Peptide Label: isoform X3
Protein Domains
PH   PID

Promoters
RGD ID:13685005
Promoter ID:EPDNEW_C3073
Type:initiation region
Name:APPL2_1
Description:adaptor protein, phosphotyrosine interacting with PH domain andleucine zipper 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11033,192,324 - 33,192,384EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001885 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000002772 UniProtKB/TrEMBL
  ENSCAFP00000051353 UniProtKB/TrEMBL
  ENSCAFP00000059188 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000061729 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002989 UniProtKB/TrEMBL
  ENSCAFT00000069988 UniProtKB/TrEMBL
  ENSCAFT00000076358 UniProtKB/TrEMBL
  ENSCAFT00000080274 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  PH_dom-like UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
KEGG Report cfa:481297 UniProtKB/TrEMBL
NCBI Gene APPL2 ENTREZGENE
Pfam PF00169 UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
UniProt A0A5F4CAP7_CANLF UniProtKB/TrEMBL
  A0A5F4D2V9_CANLF UniProtKB/TrEMBL
  A0A5F4D4T2_CANLF UniProtKB/TrEMBL
  E2RGZ8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38013 ENTREZGENE