GNMT (glycine N-methyltransferase) - Rat Genome Database

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Gene: GNMT (glycine N-methyltransferase) Canis lupus familiaris
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Symbol: GNMT
Name: glycine N-methyltransferase
RGD ID: 12223780
Description: ENCODES a protein that exhibits folic acid binding (ortholog); glycine N-methyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glycine metabolic process (ortholog); glycogen metabolic process (ortholog); methionine metabolic process (ortholog); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH Chronic Hepatitis (ortholog); glycine N-methyltransferase deficiency (ortholog); hepatitis (ortholog); FOUND IN cytosol (ortholog); methyltransferase complex (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,500,363 - 11,503,075 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,500,392 - 11,503,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,527,380 - 11,530,090 (+)NCBI
ROS_Cfam_1.01211,981,562 - 11,984,272 (+)NCBI
UMICH_Zoey_3.11211,509,980 - 11,512,694 (+)NCBI
UNSW_CanFamBas_1.01211,594,281 - 11,596,795 (+)NCBI
UU_Cfam_GSD_1.01211,688,299 - 11,691,025 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
GNMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,500,363 - 11,503,075 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,500,392 - 11,503,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,527,380 - 11,530,090 (+)NCBI
ROS_Cfam_1.01211,981,562 - 11,984,272 (+)NCBI
UMICH_Zoey_3.11211,509,980 - 11,512,694 (+)NCBI
UNSW_CanFamBas_1.01211,594,281 - 11,596,795 (+)NCBI
UU_Cfam_GSD_1.01211,688,299 - 11,691,025 (+)NCBI
GNMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl642,960,754 - 42,963,880 (+)EnsemblGRCh38hg38GRCh38
GRCh38642,960,754 - 42,963,880 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37642,928,492 - 42,931,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,036,478 - 43,039,596 (+)NCBINCBI36hg18NCBI36
Build 34643,036,477 - 43,039,595NCBI
Celera644,480,758 - 44,483,869 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef642,645,801 - 42,648,911 (+)NCBIHuRef
CHM1_1642,930,969 - 42,934,095 (+)NCBICHM1_1
Gnmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,036,590 - 47,040,137 (-)NCBIGRCm39mm39
GRCm39 Ensembl1747,036,590 - 47,040,094 (-)Ensembl
GRCm381746,725,664 - 46,729,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,725,664 - 46,729,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,862,613 - 46,866,114 (-)NCBIGRCm37mm9NCBIm37
MGSCv361746,188,855 - 46,192,356 (-)NCBImm8
Celera1750,161,350 - 50,164,841 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Gnmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,254,675 - 14,258,028 (+)NCBI
Rnor_6.0 Ensembl916,565,225 - 16,568,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0916,565,274 - 16,568,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0915,471,889 - 15,475,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,127,092 - 10,130,444 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1910,124,413 - 10,127,766 (+)NCBI
Celera912,003,123 - 12,006,473 (+)NCBICelera
Cytogenetic Map9q12NCBI
Gnmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,944,047 - 8,946,642 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,944,288 - 8,946,642 (+)NCBIChiLan1.0ChiLan1.0
GNMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1643,846,560 - 43,849,679 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,846,560 - 43,849,679 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0642,550,631 - 42,554,385 (+)NCBIMhudiblu_PPA_v0panPan3
Gnmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494646,995,031 - 46,998,424 (+)NCBI
SpeTri2.0NW_00493647616,961,734 - 16,965,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,038,358 - 38,041,218 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,038,359 - 38,041,218 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,486,726 - 43,489,585 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,196,142 - 29,199,728 (-)NCBI
ChlSab1.1 Ensembl1729,196,321 - 29,198,947 (-)Ensembl
Vero_WHO_p1.0NW_02366604443,019,849 - 43,022,686 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8 6 6 3 2
Low 4 1 14 3 3 10 8 10 1
Below cutoff 1 4 3 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000002727   ⟹   ENSCAFP00000002533
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1211,500,392 - 11,503,481 (+)Ensembl
RefSeq Acc Id: XM_038491843   ⟹   XP_038347771
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11211,509,980 - 11,512,694 (+)NCBI
RefSeq Acc Id: XM_038554100   ⟹   XP_038410028
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01211,688,299 - 11,691,025 (+)NCBI
RefSeq Acc Id: XM_038617961   ⟹   XP_038473889
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01211,594,281 - 11,596,795 (+)NCBI
RefSeq Acc Id: XM_038683560   ⟹   XP_038539488
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01211,981,562 - 11,984,272 (+)NCBI
RefSeq Acc Id: XM_532140   ⟹   XP_532140
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11211,500,363 - 11,503,075 (+)NCBI
Dog10K_Boxer_Tasha1211,527,380 - 11,530,090 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038347771 (Get FASTA)   NCBI Sequence Viewer  
  XP_038410028 (Get FASTA)   NCBI Sequence Viewer  
  XP_038473889 (Get FASTA)   NCBI Sequence Viewer  
  XP_038539488 (Get FASTA)   NCBI Sequence Viewer  
  XP_532140 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_532140   ⟸   XM_532140
- Sequence:
RefSeq Acc Id: ENSCAFP00000002533   ⟸   ENSCAFT00000002727
RefSeq Acc Id: XP_038347771   ⟸   XM_038491843
RefSeq Acc Id: XP_038473889   ⟸   XM_038617961
RefSeq Acc Id: XP_038539488   ⟸   XM_038683560
RefSeq Acc Id: XP_038410028   ⟸   XM_038554100
Protein Domains
Methyltransf_25

Promoters
RGD ID:13685429
Promoter ID:EPDNEW_C3497
Type:single initiation site
Name:GNMT_1
Description:glycine N-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11211,500,387 - 11,500,447EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001741 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000002533 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002727 UniProtKB/TrEMBL
InterPro Gly/Sar_N_MeTrfase UniProtKB/TrEMBL
  Methyltransf_25 UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report cfa:474905 UniProtKB/TrEMBL
NCBI Gene GNMT ENTREZGENE
PANTHER PTHR16458 UniProtKB/TrEMBL
Pfam Methyltransf_25 UniProtKB/TrEMBL
PIRSF Gly_N-mtase UniProtKB/TrEMBL
PROSITE SAM_GNMT UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt E2RDH0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41329 ENTREZGENE