FGF18 (fibroblast growth factor 18) - Rat Genome Database

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Gene: FGF18 (fibroblast growth factor 18) Canis lupus familiaris
Analyze
Symbol: FGF18
Name: fibroblast growth factor 18
RGD ID: 12223660
Description: ENCODES a protein that exhibits type 1 fibroblast growth factor receptor binding (ortholog); type 2 fibroblast growth factor receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); cell population proliferation (ortholog); chondrocyte development (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH Diaphragmatic Hernia (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN nucleolus (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1440,714,891 - 40,748,892 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl440,715,060 - 40,748,518 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha440,660,286 - 40,697,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0441,089,249 - 41,126,052 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl441,091,859 - 41,126,139 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1440,904,218 - 40,941,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0441,094,435 - 41,131,275 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0441,604,558 - 41,641,375 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21418347   PMID:22301074   PMID:22808925   PMID:30032202  


Genomics

Comparative Map Data
FGF18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1440,714,891 - 40,748,892 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl440,715,060 - 40,748,518 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha440,660,286 - 40,697,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0441,089,249 - 41,126,052 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl441,091,859 - 41,126,139 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1440,904,218 - 40,941,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0441,094,435 - 41,131,275 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0441,604,558 - 41,641,375 (-)NCBIUU_Cfam_GSD_1.0
FGF18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385171,419,647 - 171,457,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5171,419,647 - 171,457,626 (+)EnsemblGRCh38hg38GRCh38
GRCh375170,846,651 - 170,884,630 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365170,779,272 - 170,816,781 (+)NCBINCBI36Build 36hg18NCBI36
Build 345170,779,271 - 170,816,781NCBI
Celera5166,879,014 - 166,916,982 (+)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5165,944,447 - 165,981,862 (+)NCBIHuRef
CHM1_15170,279,191 - 170,317,159 (+)NCBICHM1_1
T2T-CHM13v2.05171,959,977 - 171,997,979 (+)NCBIT2T-CHM13v2.0
Fgf18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,066,970 - 33,097,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,067,430 - 33,097,400 (-)EnsemblGRCm39 Ensembl
GRCm381133,116,970 - 33,147,400 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,117,430 - 33,147,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,017,430 - 33,047,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,017,430 - 33,047,400 (-)NCBIMGSCv36mm8
Celera1135,529,642 - 35,559,689 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.21NCBI
Fgf18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81018,210,240 - 18,241,929 (-)NCBIGRCr8
mRatBN7.21017,706,011 - 17,737,702 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1017,706,174 - 17,736,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1022,455,024 - 22,484,592 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01021,943,626 - 21,973,192 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01017,432,271 - 17,461,845 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01018,047,109 - 18,082,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1018,047,109 - 18,063,391 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01017,932,880 - 17,967,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1017,348,236 - 17,383,370 (-)NCBICelera
Cytogenetic Map10q12NCBI
Fgf18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540824,225,459 - 24,260,092 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540824,225,459 - 24,260,057 (+)NCBIChiLan1.0ChiLan1.0
FGF18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24166,553,461 - 166,591,129 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15164,693,000 - 164,730,916 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05166,765,061 - 166,802,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Fgf18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721394,954,910 - 94,983,832 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366093,677,237 - 3,706,517 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366093,677,661 - 3,706,511 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1652,725,356 - 52,759,791 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11652,724,867 - 52,760,246 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21656,920,916 - 56,956,478 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12373,584,223 - 73,620,881 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2373,584,766 - 73,620,069 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660345,019,198 - 5,060,806 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473318,599,557 - 18,633,016 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473318,599,186 - 18,633,065 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF18
306 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 1 3
Low 5 5 11 6 4 4 6 8 9 3
Below cutoff 11 6 6 2 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005619215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038473690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038599071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038663376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_849332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005324414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005335985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005392711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005425817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000026760   ⟹   ENSCAFP00000024864
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl440,715,755 - 40,748,518 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081804   ⟹   ENSCAFP00000049040
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl440,720,971 - 40,748,518 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081836   ⟹   ENSCAFP00000060840
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl440,715,060 - 40,748,518 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081920   ⟹   ENSCAFP00000059544
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl440,720,971 - 40,748,334 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002897   ⟹   ENSCAFP00845002309
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl441,091,859 - 41,126,139 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002925   ⟹   ENSCAFP00845002333
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl441,092,400 - 41,126,139 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002946   ⟹   ENSCAFP00845002350
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl441,092,400 - 41,126,139 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002971   ⟹   ENSCAFP00845002367
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl441,092,400 - 41,126,139 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002989   ⟹   ENSCAFP00845002381
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl441,092,400 - 41,117,148 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845003015   ⟹   ENSCAFP00845002406
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl441,098,592 - 41,126,139 (-)Ensembl
RefSeq Acc Id: XM_038473690   ⟹   XP_038329618
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1440,907,989 - 40,941,026 (-)NCBI
RefSeq Acc Id: XM_038534771   ⟹   XP_038390699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0441,608,330 - 41,641,375 (-)NCBI
RefSeq Acc Id: XM_038599071   ⟹   XP_038454999
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0441,098,204 - 41,131,275 (-)NCBI
RefSeq Acc Id: XM_038663376   ⟹   XP_038519304
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0441,093,021 - 41,126,052 (-)NCBI
RefSeq Acc Id: XM_849332   ⟹   XP_854425
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1440,715,234 - 40,748,453 (-)NCBI
Dog10K_Boxer_Tasha440,664,038 - 40,697,075 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005324414
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1440,904,218 - 40,941,026 (-)NCBI
RefSeq Acc Id: XR_005335985
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha440,660,286 - 40,697,075 (-)NCBI
RefSeq Acc Id: XR_005358196
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0441,604,558 - 41,641,375 (-)NCBI
RefSeq Acc Id: XR_005392711
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0441,094,435 - 41,131,275 (-)NCBI
RefSeq Acc Id: XR_005425817
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0441,089,249 - 41,126,052 (-)NCBI
RefSeq Acc Id: XP_854425   ⟸   XM_849332
- UniProtKB: A0A7U3JWC4 (UniProtKB/TrEMBL),   A0A8C0K4C5 (UniProtKB/TrEMBL),   A0A8C0LU80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000059544   ⟸   ENSCAFT00000081920
RefSeq Acc Id: ENSCAFP00000049040   ⟸   ENSCAFT00000081804
RefSeq Acc Id: ENSCAFP00000060840   ⟸   ENSCAFT00000081836
RefSeq Acc Id: ENSCAFP00000024864   ⟸   ENSCAFT00000026760
RefSeq Acc Id: XP_038329618   ⟸   XM_038473690
RefSeq Acc Id: XP_038454999   ⟸   XM_038599071
RefSeq Acc Id: XP_038519304   ⟸   XM_038663376
- UniProtKB: A0A7U3JWC4 (UniProtKB/TrEMBL),   A0A8C0K4C5 (UniProtKB/TrEMBL),   A0A8C0LU80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390699   ⟸   XM_038534771
- UniProtKB: A0A7U3JWC4 (UniProtKB/TrEMBL),   A0A8C0K4C5 (UniProtKB/TrEMBL),   A0A8C0LU80 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845002309   ⟸   ENSCAFT00845002897
RefSeq Acc Id: ENSCAFP00845002350   ⟸   ENSCAFT00845002946
RefSeq Acc Id: ENSCAFP00845002381   ⟸   ENSCAFT00845002989
RefSeq Acc Id: ENSCAFP00845002333   ⟸   ENSCAFT00845002925
RefSeq Acc Id: ENSCAFP00845002367   ⟸   ENSCAFT00845002971
RefSeq Acc Id: ENSCAFP00845002406   ⟸   ENSCAFT00845003015

Promoters
RGD ID:13682985
Promoter ID:EPDNEW_C1052
Type:single initiation site
Name:FGF18_1
Description:fibroblast growth factor 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1440,749,281 - 40,749,341EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016903 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001142 UniProtKB/TrEMBL
  ENSCAFG00040000905 UniProtKB/TrEMBL
  ENSCAFG00845001658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026760.5 UniProtKB/TrEMBL
  ENSCAFT00000081804.2 UniProtKB/TrEMBL
  ENSCAFT00000081836.2 UniProtKB/TrEMBL
  ENSCAFT00000094202.1 UniProtKB/TrEMBL
  ENSCAFT00000096084.1 UniProtKB/TrEMBL
  ENSCAFT00000099778.1 UniProtKB/TrEMBL
  ENSCAFT00030001985.1 UniProtKB/TrEMBL
  ENSCAFT00030001998.1 UniProtKB/TrEMBL
  ENSCAFT00030002009.1 UniProtKB/TrEMBL
  ENSCAFT00040001632.1 UniProtKB/TrEMBL
  ENSCAFT00845002897.1 UniProtKB/TrEMBL
  ENSCAFT00845002925.1 UniProtKB/TrEMBL
  ENSCAFT00845002946 ENTREZGENE
  ENSCAFT00845002946.1 UniProtKB/TrEMBL
  ENSCAFT00845002971.1 UniProtKB/TrEMBL
  ENSCAFT00845002989.1 UniProtKB/TrEMBL
  ENSCAFT00845003015.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
KEGG Report cfa:611641 UniProtKB/TrEMBL
NCBI Gene FGF18 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF4 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PRINTS IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A7U3JWC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0K4C5 ENTREZGENE
  A0A8C0LU80 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0LXT9_CANLF UniProtKB/TrEMBL
  A0A8C0RA05_CANLF UniProtKB/TrEMBL
  A0A8I3MEA9_CANLF UniProtKB/TrEMBL
  A0A8I3MGL8_CANLF UniProtKB/TrEMBL
  A0A8I3MGN4_CANLF UniProtKB/TrEMBL
  A0A8I3MGR5_CANLF UniProtKB/TrEMBL
  A0A8I3MIK8_CANLF UniProtKB/TrEMBL
  A0A8P0NZ05_CANLF UniProtKB/TrEMBL
  A0A8P0PQ00_CANLF UniProtKB/TrEMBL
  A0A8P0TMP4_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40845 ENTREZGENE