ADAM20 (ADAM metallopeptidase domain 20)

Gene: ADAM20 (ADAM metallopeptidase domain 20) Canis lupus familiaris

Analyze

Symbol:

ADAM20

Name:

ADAM metallopeptidase domain 20

RGD ID:

12221560

Description:

ENCODES a protein that exhibits metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN male gonad development (inferred); proteolysis (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN external side of plasma membrane (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

disintegrin and metalloproteinase domain-containing protein 20

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	44,263,467 - 44,266,287 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	44,264,008 - 44,266,287 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	43,928,823 - 43,931,643 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	44,487,859 - 44,490,680 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	44,488,401 - 44,490,680 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	44,139,990 - 44,142,813 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	44,186,840 - 44,189,658 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	44,547,780 - 44,550,604 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

male gonad development (IEA)

proteolysis (IEA)

Cellular Component

external side of plasma membrane (IEA)

membrane (IEA)

plasma membrane (IEA)

sperm head plasma membrane (IEA)

Molecular Function

metal ion binding (IEA)

metalloendopeptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ADAM20
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	44,263,467 - 44,266,287 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	44,264,008 - 44,266,287 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	43,928,823 - 43,931,643 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	44,487,859 - 44,490,680 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	44,488,401 - 44,490,680 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	44,139,990 - 44,142,813 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	44,186,840 - 44,189,658 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	44,547,780 - 44,550,604 (-)	NCBI		UU_Cfam_GSD_1.0

ADAM20
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	70,522,358 - 70,579,452 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	70,522,358 - 70,535,015 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	70,989,075 - 71,001,721 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	70,058,831 - 70,071,485 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	70,058,831 - 70,071,485	NCBI
Celera	14	51,053,033 - 51,065,687 (-)	NCBI		Celera
Cytogenetic Map	14	q24.2	NCBI
HuRef	14	51,157,745 - 51,170,399 (-)	NCBI		HuRef
CHM1_1	14	70,927,229 - 70,939,873 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	64,728,380 - 64,785,473 (-)	NCBI		T2T-CHM13v2.0

Adam20
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	41,246,310 - 41,250,379 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	41,246,310 - 41,250,340 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	40,793,273 - 40,797,342 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	40,793,273 - 40,797,303 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	41,878,627 - 41,882,657 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	42,293,672 - 42,295,954 (+)	NCBI		MGSCv36	mm8
Celera	8	43,426,818 - 43,430,857 (+)	NCBI		Celera
Cytogenetic Map	8	A4	NCBI
cM Map	8	23.89	NCBI

LOC101958461
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	31,891,083 - 31,926,366 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936488	142,777 - 145,399 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100739754
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	94,127,736 - 94,129,904 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	94,125,901 - 94,131,479 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	100,392,940 - 100,439,037 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Variants

Variants in ADAM20
18 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium
Low			4							8	4
Below cutoff	3	2	12	2	5	2	5	1	11		6	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022422456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038484427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038545976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038608199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038673002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000026396 ⟹ ENSCAFP00000024513

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	44,264,008 - 44,266,287 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845013368 ⟹ ENSCAFP00845010371

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	8	44,488,401 - 44,490,680 (-)	Ensembl

RefSeq Acc Id:

XM_022422456 ⟹ XP_022278164

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	8	44,263,467 - 44,266,287 (-)	NCBI
Dog10K_Boxer_Tasha	8	43,928,823 - 43,931,643 (-)	NCBI

Sequence:

show sequence

ATGTCAGCCCTGCACCCTAAGCAGCTCACAGGGAGGAGCCAGACCAGCAGCACCCCACACCCTG
CCCTCTCTTCTGCCCTGGACAGATGGCTCCATGATGACAGCTCCATAATGGCACTGGGTGAGGC
CCTGGTGCACATCACGGTCACTCTTCTGATACTCTGGGTAGGAATGTCTCTGTTCATTTCTGGC
CACTCTCAGGCAATGCCCTCCCAGCACTTCTCCCCAGAATTGGTGATCCCCTTGAAGGTGACTG
GCAGGGGCAGAAGTGCAAAATCTCCAGGCTGGCTCTCCTACAGCCTGAAGTTTGGGGGCCAGAG
ACACATTGTCCACATGAGGGTCAAGAAGTTCTTGCTTTCCAAACACTTCCCAGTGTTCACCTAC
ACGGACCAGCACGCCCTCCTCCAGGATCAGCCTTTTGTTCCTGATGACTGCTACTATCATGGTT
ATGTGGAAGGAATCTCTGAGTCCCTGGTTGCCCTCAGTACCTGTTCCGGAGGTTTTCGAGGAAT
GCTACAGATTAATGACCTTGCTTATGAAATTGAGCCAATTAGTTTTTCTGCCACATTTGAACAC
CTGGTGTATAAGATAGACAGTGGTGATACACAGTTCCCACCTATGAGATGTGGGTTAACAGAAG
AGGAAATAGCACGCCATTTGCAGTTGAGGGCATCATATAATTCTACTCTGATGCAAAATTCTTA
CTTGGGCTGGTGGACCCACTTGCGGTTTGTTGAGCTGGTCGTAGTTGTGGACCATTTTCGATAC
CTTTACTGTAAAAGTAATGTGTCATTAGTACAGCGTGAAGTATTTGATACTGTCAATATAATTG
GTATCTTATATAGCCCTTTGGAGGTTGAAATAGTTTTGAATGGGATTGAAATCTGGAGTGAAAG
AAACCTGATTTCCACTGATACTATAGAACAGATTTTGGGGGATTTTTCTGCTTGGAAGTTTTCC
AATCTTGATGACCGACTCCCCCATGATACTGCCCATCTTTTCATTAAAAAAAATTTTGGTATAA
AGCTTGGAGTTGCCTACGTTGGAGGAATATGCCATCGTCTTTTTAATAGTGGAGTTGATGTCTT
TGAAGAAGACCGTCTGTATCTTTTTGCACTTACTGTGACCCATGAACTTGGTCATAATATGGGT
ATGACTCATGATACTAAAGAATGTAAGTGTGGGCTTCCGTGGTGCATAATGTATGACTCCCAGA
GTGTGACAGCTCGGTTCAGCAATTGCAGTTATGCCGAGTATTGGAACAATATTCTCACTAAGGG
ATTATGTATTCACTCACCTCCATATCCAGGGAATGTCTTTAAGGTACAGTACTGTGGGAACCTA
GTGATTGAAGAAGGAGAGGAGTGTGATTGTGGGACCACAGACCAGTGTGTAAATGATCCCTGTT
GTCTGTTGAACTGCACTCTGAAGCCTGGAGCTGCTTGTCAGTTTGGAATTTGTTGCAAAGACTG
CAAGTTAATGCCATCAGGGACTTTGTGCAGACATCAGATCAGTGAATGTGACCTTCCAGAATGG
TGCAATGGGACATTTCATCAATGCCCAGAAGATGTATATGTGCAGGACGGGATTCCCTGTGGTG
ACAATGCCTACTGCTATGAAGGGAGATGTAATAACCATGACAAACAGTGCAGGGAGATTTTTGG
CAAAGATGCAAGGAGTGCATCTCAGAGTTGCTACAAAGAAATCAACACCCAAGGAAATCGATTT
GGTCACTGTGGTATCACCAACCTAGTATACGTGAAATGTGAGGGCCCTGATATTCTGTGTGGGA
GAGTGCAGTGTGAAAATGTAGAAATGATTCCTAATCTGATCCAACATTCTACAGTGCATCAGCT
TCACATCAATGATACCACTTGCTGGGGCACTGATTTTCATTTAGGGATGTCCATACCTGATGTT
GGTCAAGTGAAAGATGGCACAATATGTGGTCCAGAAAAGATCTGCCTCCATAAGAAGTGTGTCA
ATATGACCTATCCGCCACGAAAGTGTCATTCTAATGAGACCTGCCACATGCATGGAGTCTGTAA
TAATAAACAGCATTGCCACTGCAAGCATGGATGGGCACCTCCCTACTGCAAGGACGCAGGCCTT
GGAGGCAGCGTGGACAGCGGGCCACCTCCTAAGGAATACGTGGCAACGCTCGAAGCAAAGGCAT
TAACCACCTTCATTCTTGCTGAGAAGTACCGGCACCCTCAAGAGATCTGA

hide sequence

RefSeq Acc Id:

XM_038484427 ⟹ XP_038340355

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	8	44,139,990 - 44,142,813 (-)	NCBI

RefSeq Acc Id:

XM_038545976 ⟹ XP_038401904

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	8	44,547,780 - 44,550,604 (-)	NCBI

RefSeq Acc Id:

XM_038608199 ⟹ XP_038464127

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	8	44,186,840 - 44,189,658 (-)	NCBI

RefSeq Acc Id:

XM_038673002 ⟹ XP_038528930

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	8	44,487,859 - 44,490,680 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_022278164	(Get FASTA)	NCBI Sequence Viewer
	XP_038340355	(Get FASTA)	NCBI Sequence Viewer
	XP_038401904	(Get FASTA)	NCBI Sequence Viewer
	XP_038464127	(Get FASTA)	NCBI Sequence Viewer
	XP_038528930	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000024513.3
	ENSCAFP00040024589.1
	ENSCAFP00845010371.1

RefSeq Acc Id:

XP_022278164 ⟸ XM_022422456

- UniProtKB:

A0A8I3N489 (UniProtKB/TrEMBL), A0A8P0SL56 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSALHPKQLTGRSQTSSTPHPALSSALDRWLHDDSSIMALGEALVHITVTLLILWVGMSLFISG
HSQAMPSQHFSPELVIPLKVTGRGRSAKSPGWLSYSLKFGGQRHIVHMRVKKFLLSKHFPVFTY
TDQHALLQDQPFVPDDCYYHGYVEGISESLVALSTCSGGFRGMLQINDLAYEIEPISFSATFEH
LVYKIDSGDTQFPPMRCGLTEEEIARHLQLRASYNSTLMQNSYLGWWTHLRFVELVVVVDHFRY
LYCKSNVSLVQREVFDTVNIIGILYSPLEVEIVLNGIEIWSERNLISTDTIEQILGDFSAWKFS
NLDDRLPHDTAHLFIKKNFGIKLGVAYVGGICHRLFNSGVDVFEEDRLYLFALTVTHELGHNMG
MTHDTKECKCGLPWCIMYDSQSVTARFSNCSYAEYWNNILTKGLCIHSPPYPGNVFKVQYCGNL
VIEEGEECDCGTTDQCVNDPCCLLNCTLKPGAACQFGICCKDCKLMPSGTLCRHQISECDLPEW
CNGTFHQCPEDVYVQDGIPCGDNAYCYEGRCNNHDKQCREIFGKDARSASQSCYKEINTQGNRF
GHCGITNLVYVKCEGPDILCGRVQCENVEMIPNLIQHSTVHQLHINDTTCWGTDFHLGMSIPDV
GQVKDGTICGPEKICLHKKCVNMTYPPRKCHSNETCHMHGVCNNKQHCHCKHGWAPPYCKDAGL
GGSVDSGPPPKEYVATLEAKALTTFILAEKYRHPQEI

hide sequence

RefSeq Acc Id:

ENSCAFP00000024513 ⟸ ENSCAFT00000026396

RefSeq Acc Id:

XP_038340355 ⟸ XM_038484427

RefSeq Acc Id:

XP_038464127 ⟸ XM_038608199

RefSeq Acc Id:	XP_038528930 ⟸ XM_038673002
- UniProtKB:	A0A8I3N489 (UniProtKB/TrEMBL), A0A8P0SL56 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038401904 ⟸ XM_038545976
- UniProtKB:	A0A8I3N489 (UniProtKB/TrEMBL), A0A8P0SL56 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845010371 ⟸ ENSCAFT00845013368

Protein Domains

Disintegrin EGF-like Peptidase M12B

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000016666	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00040015381	UniProtKB/TrEMBL
	ENSCAFG00845007590	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000026396.4	UniProtKB/TrEMBL
	ENSCAFT00040028308.1	UniProtKB/TrEMBL
	ENSCAFT00845013368.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.390.10	UniProtKB/TrEMBL
	4.10.70.10	UniProtKB/TrEMBL
InterPro	ADAM_Cys-rich	UniProtKB/TrEMBL
	Disintegrin_CS	UniProtKB/TrEMBL
	Disintegrin_dom	UniProtKB/TrEMBL
	Disintegrin_dom_sf	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	MetalloPept_cat_dom_sf	UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/TrEMBL
	Peptidase_M12B_N	UniProtKB/TrEMBL
	Reprolysin_adamalysin	UniProtKB/TrEMBL
NCBI Gene	ADAM20	ENTREZGENE
PANTHER	ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN	UniProtKB/TrEMBL
	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 20	UniProtKB/TrEMBL
Pfam	ADAM_CR	UniProtKB/TrEMBL
	Disintegrin	UniProtKB/TrEMBL
	Pep_M12B_propep	UniProtKB/TrEMBL
	Reprolysin	UniProtKB/TrEMBL
PROSITE	ADAM_MEPRO	UniProtKB/TrEMBL
	DISINTEGRIN_1	UniProtKB/TrEMBL
	DISINTEGRIN_2	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
SMART	ACR	UniProtKB/TrEMBL
	DISIN	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
	SSF57552	UniProtKB/TrEMBL
UniProt	A0A8C0SPV9_CANLF	UniProtKB/TrEMBL
	A0A8I3N489	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SL56	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:37578	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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