HPGDS (hematopoietic prostaglandin D synthase) - Rat Genome Database

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Gene: HPGDS (hematopoietic prostaglandin D synthase) Canis lupus familiaris
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Symbol: HPGDS
Name: hematopoietic prostaglandin D synthase
RGD ID: 12219450
Description: ENCODES a protein that exhibits calcium ion binding (inferred); glutathione transferase activity (inferred); magnesium ion binding (inferred); INVOLVED IN negative regulation of male germ cell proliferation (ortholog); prostaglandin metabolic process (ortholog); PARTICIPATES IN prostaglandin biosynthetic pathway; prostanoid metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); Kidney Neoplasms (ortholog); FOUND IN cytosol (inferred); intracellular membrane-bounded organelle (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H-PGDS
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13217,172,372 - 17,196,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3217,121,968 - 17,196,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3224,752,940 - 24,777,413 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03217,315,689 - 17,375,451 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3217,351,003 - 17,375,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13217,323,037 - 17,347,505 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03217,137,331 - 17,161,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03222,730,052 - 22,754,426 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
HPGDS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13217,172,372 - 17,196,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3217,121,968 - 17,196,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3224,752,940 - 24,777,413 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03217,315,689 - 17,375,451 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3217,351,003 - 17,375,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13217,323,037 - 17,347,505 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03217,137,331 - 17,161,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03222,730,052 - 22,754,426 (+)NCBIUU_Cfam_GSD_1.0
HPGDS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38494,298,535 - 94,342,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl494,298,535 - 94,342,876 (-)EnsemblGRCh38hg38GRCh38
GRCh37495,219,686 - 95,263,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36495,438,730 - 95,483,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 34495,577,633 - 95,612,968NCBI
Celera492,516,831 - 92,561,280 (-)NCBICelera
Cytogenetic Map4q22.3NCBI
HuRef490,957,458 - 91,001,835 (-)NCBIHuRef
CHM1_1495,196,420 - 95,241,397 (-)NCBICHM1_1
T2T-CHM13v2.0497,614,053 - 97,658,342 (-)NCBIT2T-CHM13v2.0
Hpgds
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39665,094,019 - 65,121,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl665,094,277 - 65,121,892 (-)EnsemblGRCm39 Ensembl
GRCm38665,117,293 - 65,144,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl665,117,293 - 65,144,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv37665,067,287 - 65,094,724 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36665,048,942 - 65,074,308 (-)NCBIMGSCv36mm8
Celera667,246,090 - 67,273,526 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.11NCBI
Hpgds
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8495,698,265 - 95,727,733 (-)NCBIGRCr8
mRatBN7.2494,368,426 - 94,397,931 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl494,373,342 - 94,397,883 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx499,611,191 - 99,635,963 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0495,386,132 - 95,410,900 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0493,798,205 - 93,822,753 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0495,945,356 - 95,970,666 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl495,946,025 - 95,970,666 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04160,734,255 - 160,758,902 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4494,611,607 - 94,636,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1494,856,088 - 94,880,628 (-)NCBI
Celera489,106,678 - 89,131,218 (-)NCBICelera
Cytogenetic Map4q31NCBI
HPGDS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2392,324,323 - 92,367,772 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1492,595,665 - 92,647,007 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0486,659,551 - 86,702,995 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1497,332,231 - 97,375,684 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl497,332,231 - 97,375,815 (-)Ensemblpanpan1.1panPan2
Hpgds
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530124,462,666 - 24,540,537 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366871,805,830 - 1,884,319 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366871,806,452 - 1,884,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPGDS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8125,375,867 - 125,405,955 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18125,375,906 - 125,406,066 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28134,662,192 - 134,692,377 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPGDS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1742,555,151 - 42,592,457 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl742,553,848 - 42,592,400 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603720,918,448 - 20,961,381 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpgds
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475722,114,249 - 22,140,059 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475722,114,917 - 22,166,833 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HPGDS
273 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 2 1 1 1 1 6 3 6
Below cutoff 4 3 21 5 5 5 3 12 2 7

Sequence


RefSeq Acc Id: ENSCAFT00000015956   ⟹   ENSCAFP00000014759
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3217,121,968 - 17,196,851 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000076856   ⟹   ENSCAFP00000051181
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3217,163,878 - 17,196,851 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086265   ⟹   ENSCAFP00000061205
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3217,172,418 - 17,196,851 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845036567   ⟹   ENSCAFP00845028615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3217,351,003 - 17,375,432 (-)Ensembl
RefSeq Acc Id: NM_001200044   ⟹   NP_001186973
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13217,172,372 - 17,196,851 (-)NCBI
Dog10K_Boxer_Tasha3224,752,940 - 24,777,413 (+)NCBI
ROS_Cfam_1.03217,350,957 - 17,375,432 (-)NCBI
UMICH_Zoey_3.13217,323,037 - 17,347,505 (-)NCBI
UNSW_CanFamBas_1.03217,137,331 - 17,161,789 (-)NCBI
UU_Cfam_GSD_1.03222,730,052 - 22,754,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038443784   ⟹   XP_038299712
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03217,340,190 - 17,375,451 (-)NCBI
RefSeq Acc Id: XR_005305579
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03217,315,689 - 17,375,451 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001186973 (Get FASTA)   NCBI Sequence Viewer  
  XP_038299712 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAJ52718 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000061205.1
  ENSCAFP00030039399.1
  ENSCAFP00040031074.1
  ENSCAFP00845028615
  ENSCAFP00845028615.1
RefSeq Acc Id: NP_001186973   ⟸   NM_001200044
- UniProtKB: E5RQH2 (UniProtKB/TrEMBL),   A0A8C0JR43 (UniProtKB/TrEMBL),   A0A8C0PBV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014759   ⟸   ENSCAFT00000015956
RefSeq Acc Id: ENSCAFP00000061205   ⟸   ENSCAFT00000086265
RefSeq Acc Id: ENSCAFP00000051181   ⟸   ENSCAFT00000076856
RefSeq Acc Id: XP_038299712   ⟸   XM_038443784
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845028615   ⟸   ENSCAFT00845036567
Protein Domains
GST C-terminal   GST N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010032 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024535 UniProtKB/TrEMBL
  ENSCAFG00040019274 UniProtKB/TrEMBL
  ENSCAFG00845020740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000086265.2 UniProtKB/TrEMBL
  ENSCAFT00030045133.1 UniProtKB/TrEMBL
  ENSCAFT00040035683.1 UniProtKB/TrEMBL
  ENSCAFT00845036567 ENTREZGENE
  ENSCAFT00845036567.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report cfa:478481 UniProtKB/TrEMBL
NCBI Gene HPGDS ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/TrEMBL
  HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE UniProtKB/TrEMBL
Pfam GST_C_3 UniProtKB/TrEMBL
  GST_N UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
  GST_NTER UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0JR43 ENTREZGENE
  A0A8C0PBV7 ENTREZGENE, UniProtKB/TrEMBL
  E5RQH2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54312 ENTREZGENE