INTS5 (integrator complex subunit 5) - Rat Genome Database

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Gene: INTS5 (integrator complex subunit 5) Canis lupus familiaris
Analyze
Symbol: INTS5
Name: integrator complex subunit 5
RGD ID: 12217607
Description: INVOLVED IN snRNA 3'-end processing (inferred); snRNA processing (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Larsen-like syndrome B3GAT3 type (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); integrator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,998,828 - 54,004,127 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,998,897 - 54,003,957 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,603,878 - 52,609,166 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,051,324 - 55,056,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,051,335 - 55,056,674 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,147,237 - 54,152,524 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,722,566 - 53,727,856 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,517,953 - 54,523,246 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
INTS5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,998,828 - 54,004,127 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,998,897 - 54,003,957 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,603,878 - 52,609,166 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,051,324 - 55,056,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,051,335 - 55,056,674 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,147,237 - 54,152,524 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,722,566 - 53,727,856 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,517,953 - 54,523,246 (+)NCBIUU_Cfam_GSD_1.0
INTS5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,646,848 - 62,653,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,646,848 - 62,653,302 (-)EnsemblGRCh38hg38GRCh38
GRCh371162,414,320 - 62,420,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,170,896 - 62,177,350 (-)NCBINCBI36Build 36hg18NCBI36
Celera1159,743,866 - 59,750,321 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1158,743,216 - 58,749,671 (-)NCBIHuRef
CHM1_11162,297,383 - 62,303,837 (-)NCBICHM1_1
T2T-CHM13v2.01162,636,300 - 62,642,755 (-)NCBIT2T-CHM13v2.0
Ints5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39198,870,351 - 8,875,254 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl198,870,369 - 8,875,252 (+)EnsemblGRCm39 Ensembl
GRCm38198,892,987 - 8,897,890 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl198,893,005 - 8,897,888 (+)EnsemblGRCm38mm10GRCm38
MGSCv37198,967,477 - 8,972,380 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36198,960,050 - 8,964,933 (+)NCBIMGSCv36mm8
Celera198,653,728 - 8,658,629 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.95NCBI
Ints5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,218,012 - 215,222,790 (+)NCBIGRCr8
mRatBN7.21205,788,906 - 205,793,685 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,788,906 - 205,793,685 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1214,197,342 - 214,202,157 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,232,289 - 221,237,067 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01213,925,134 - 213,929,912 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,091,612 - 225,096,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,091,612 - 225,096,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,029,232 - 232,034,010 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,568,313 - 211,573,091 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,726,742 - 211,731,524 (+)NCBI
Celera1203,301,678 - 203,306,456 (+)NCBICelera
Cytogenetic Map1q43NCBI
Ints5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955599551,078 - 556,341 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955599551,989 - 556,341 (+)NCBIChiLan1.0ChiLan1.0
INTS5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2963,873,745 - 63,880,233 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,916,353 - 64,922,928 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,004,058 - 58,010,526 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,358,029 - 61,364,549 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,358,029 - 61,364,549 (-)Ensemblpanpan1.1panPan2
Ints5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,493,549 - 10,499,261 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581607,079 - 613,161 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936581607,253 - 613,080 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INTS5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl29,095,633 - 9,100,307 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.129,095,646 - 9,100,487 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,441,394 - 8,446,234 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INTS5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,251,920 - 11,257,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,251,991 - 11,257,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038108,586,766 - 108,592,540 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ints5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249261,160,935 - 1,165,414 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249261,160,997 - 1,165,451 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in INTS5
45 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 3 2 3 4 4 2 2 4
Below cutoff 2 5 20 6 3 6 2 2 10 8 8 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000024902   ⟹   ENSCAFP00000023105
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1853,998,897 - 54,003,957 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015662   ⟹   ENSCAFP00845012179
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1855,051,335 - 55,056,674 (+)Ensembl
RefSeq Acc Id: XM_038425316   ⟹   XP_038281244
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01855,051,324 - 55,056,844 (+)NCBI
RefSeq Acc Id: XM_038501584   ⟹   XP_038357512
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11854,147,237 - 54,152,524 (+)NCBI
RefSeq Acc Id: XM_038564272   ⟹   XP_038420200
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01854,517,953 - 54,523,246 (+)NCBI
RefSeq Acc Id: XM_038628410   ⟹   XP_038484338
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01853,722,566 - 53,727,856 (+)NCBI
RefSeq Acc Id: XM_849952   ⟹   XP_855045
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11853,998,828 - 54,004,127 (+)NCBI
Dog10K_Boxer_Tasha1852,603,878 - 52,609,166 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_855045   ⟸   XM_849952
- UniProtKB: A0A8C0T3Y9 (UniProtKB/TrEMBL),   A0A8P0SKA0 (UniProtKB/TrEMBL),   A0A8C0MHI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023105   ⟸   ENSCAFT00000024902
RefSeq Acc Id: XP_038357512   ⟸   XM_038501584
RefSeq Acc Id: XP_038484338   ⟸   XM_038628410
RefSeq Acc Id: XP_038281244   ⟸   XM_038425316
- UniProtKB: A0A8I3MZK3 (UniProtKB/TrEMBL),   A0A8C0MHI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420200   ⟸   XM_038564272
- UniProtKB: A0A8C0KJB5 (UniProtKB/TrEMBL),   A0A8C0MHI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845012179   ⟸   ENSCAFT00845015662
Protein Domains
Integrator complex subunit 5 C-terminal   Integrator complex subunit 5 N-terminal

Promoters
RGD ID:13686651
Promoter ID:EPDNEW_C4720
Type:multiple initiation site
Name:INTS5_1
Description:integrator complex subunit 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11853,998,850 - 53,998,910EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015724 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005905 UniProtKB/TrEMBL
  ENSCAFG00040019440 UniProtKB/TrEMBL
  ENSCAFG00845008915 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024902.5 UniProtKB/TrEMBL
  ENSCAFT00030010832.1 UniProtKB/TrEMBL
  ENSCAFT00040035957.1 UniProtKB/TrEMBL
  ENSCAFT00845015662 ENTREZGENE
  ENSCAFT00845015662.1 UniProtKB/TrEMBL
InterPro INTS5 UniProtKB/TrEMBL
  INTS5_C UniProtKB/TrEMBL
  INTS5_N UniProtKB/TrEMBL
KEGG Report cfa:612216 UniProtKB/TrEMBL
NCBI Gene INTS5 ENTREZGENE
PANTHER INTEGRATOR COMPLEX SUBUNIT 5 UniProtKB/TrEMBL
  PTHR31697 UniProtKB/TrEMBL
Pfam INTS5_C UniProtKB/TrEMBL
  INTS5_N UniProtKB/TrEMBL
UniProt A0A8C0KJB5 ENTREZGENE
  A0A8C0MHI7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T3Y9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MZK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SKA0 ENTREZGENE
UniProt Secondary A0A8P0SKA0 UniProtKB/TrEMBL
VGNC ID VGNC:42053 ENTREZGENE