WEE2 (WEE2 oocyte meiosis inhibiting kinase) - Rat Genome Database

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Gene: WEE2 (WEE2 oocyte meiosis inhibiting kinase) Canis lupus familiaris
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Symbol: WEE2
Name: WEE2 oocyte meiosis inhibiting kinase
RGD ID: 12215874
Description: ENCODES a protein that exhibits ATP binding (inferred); magnesium ion binding (inferred); metal ion binding (inferred); INVOLVED IN female meiotic nuclear division (ortholog); female pronucleus assembly (ortholog); negative regulation of cyclin-dependent protein serine/threonine kinase activity (ortholog); ASSOCIATED WITH Oocyte Maturation Defect 5 (ortholog); RASopathy (ortholog); Sengers syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WEE1 homolog 2; Wee1-like protein kinase 1B; Wee1-like protein kinase 2; WEE1B; Wee1B kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,466,651 - 7,485,150 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,467,266 - 7,499,130 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,311,310 - 8,343,770 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,388,266 - 7,420,732 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,388,878 - 7,420,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,341,543 - 7,374,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,183,901 - 7,216,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,251,671 - 7,284,345 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISS)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA,ISS)
plasma membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WEE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,466,651 - 7,485,150 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,467,266 - 7,499,130 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,311,310 - 8,343,770 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,388,266 - 7,420,732 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,388,878 - 7,420,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,341,543 - 7,374,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,183,901 - 7,216,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,251,671 - 7,284,345 (-)NCBIUU_Cfam_GSD_1.0
WEE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387141,708,353 - 141,731,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7141,708,353 - 141,731,271 (+)EnsemblGRCh38hg38GRCh38
GRCh377141,408,153 - 141,431,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,054,622 - 141,077,540 (+)NCBINCBI36Build 36hg18NCBI36
Build 347140,861,336 - 140,883,302NCBI
Celera7136,129,792 - 136,152,709 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7135,704,961 - 135,727,878 (+)NCBIHuRef
CHM1_17141,342,465 - 141,365,372 (+)NCBICHM1_1
T2T-CHM13v2.07143,024,205 - 143,047,114 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27140,745,872 - 140,768,791 (+)NCBI
Wee2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,412,180 - 40,443,749 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,416,022 - 40,443,747 (+)EnsemblGRCm39 Ensembl
GRCm38640,435,246 - 40,466,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,439,088 - 40,466,813 (+)EnsemblGRCm38mm10GRCm38
MGSCv37640,392,862 - 40,416,814 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,372,575 - 40,396,418 (+)NCBIMGSCv36mm8
Celera640,430,259 - 40,454,228 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.82NCBI
Wee2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8470,204,459 - 70,228,813 (+)NCBIGRCr8
mRatBN7.2469,239,043 - 69,261,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl469,239,299 - 69,261,093 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0468,604,770 - 68,631,341 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl468,608,137 - 68,629,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04133,391,852 - 133,417,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,997,589 - 68,021,263 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera464,238,994 - 64,263,937 (+)NCBICelera
Cytogenetic Map4q23NCBI
Wee2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,837,613 - 1,867,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,836,909 - 1,869,384 (-)NCBIChiLan1.0ChiLan1.0
WEE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26178,497,387 - 178,520,225 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1730,507,642 - 30,530,480 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07133,635,359 - 133,663,153 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17146,110,121 - 146,132,872 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,110,121 - 146,132,872 (+)Ensemblpanpan1.1panPan2
Wee2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,610,770 - 13,635,773 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365925,584,064 - 5,608,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WEE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,171,138 - 8,195,957 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,171,133 - 8,196,836 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,463,322 - 8,489,149 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WEE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,450,650 - 110,485,249 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21110,463,560 - 110,484,301 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660727,129,105 - 7,163,819 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wee2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476521,719,053 - 21,742,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476521,718,666 - 21,743,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WEE2
159 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
4 5 3 18 22 16 6 5 6 1 26 15 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000006250   ⟹   ENSCAFP00000005790
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl167,467,266 - 7,499,130 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845055016   ⟹   ENSCAFP00845043258
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl167,388,878 - 7,420,732 (-)Ensembl
RefSeq Acc Id: XM_022403732   ⟹   XP_022259440
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1167,466,651 - 7,485,150 (-)NCBI
Dog10K_Boxer_Tasha168,311,310 - 8,343,770 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038497037   ⟹   XP_038352965
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1167,341,543 - 7,374,003 (-)NCBI
RefSeq Acc Id: XM_038559370   ⟹   XP_038415298
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0167,251,671 - 7,284,345 (-)NCBI
RefSeq Acc Id: XM_038623350   ⟹   XP_038479278
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0167,183,901 - 7,216,532 (-)NCBI
RefSeq Acc Id: XM_038689074   ⟹   XP_038545002
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0167,388,266 - 7,420,732 (-)NCBI
RefSeq Acc Id: XP_022259440   ⟸   XM_022403732
- UniProtKB: E2RSS3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSCAFP00000005790   ⟸   ENSCAFT00000006250
RefSeq Acc Id: XP_038352965   ⟸   XM_038497037
RefSeq Acc Id: XP_038479278   ⟸   XM_038623350
RefSeq Acc Id: XP_038545002   ⟸   XM_038689074
- UniProtKB: E2RSS3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038415298   ⟸   XM_038559370
- UniProtKB: E2RSS3 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSCAFP00845043258   ⟸   ENSCAFT00845055016
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003889 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040006998 UniProtKB/TrEMBL
  ENSCAFG00845030950 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006250.5 UniProtKB/TrEMBL
  ENSCAFT00040013081.1 UniProtKB/TrEMBL
  ENSCAFT00845055016 ENTREZGENE
  ENSCAFT00845055016.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CC_SR_Kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wee1-like_protein_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene WEE2 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WEE1-LIKE PROTEIN KINASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Wee1-like_protein_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0RZJ1_CANLF UniProtKB/TrEMBL
  A0A8I3QQC2_CANLF UniProtKB/TrEMBL
  E2RSS3 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:48403 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-24 WEE2  WEE2 oocyte meiosis inhibiting kinase  WEE2  WEE1 homolog 2  Symbol and/or name change 5135510 APPROVED