EIF4E1B (eukaryotic translation initiation factor 4E family member 1B) - Rat Genome Database

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Gene: EIF4E1B (eukaryotic translation initiation factor 4E family member 1B) Canis lupus familiaris
Analyze
Symbol: EIF4E1B
Name: eukaryotic translation initiation factor 4E family member 1B
RGD ID: 12209785
Description: ENCODES a protein that exhibits RNA 7-methylguanosine cap binding (inferred); RNA binding (inferred); translation initiation factor activity (inferred); INVOLVED IN translation (inferred); translational initiation (inferred); ASSOCIATED WITH Chromosome 5, Trisomy 5q (ortholog); Ehlers-Danlos syndrome dermatosparaxis type (ortholog); Ehlers-Danlos syndrome spondylodysplastic type 2 (ortholog); FOUND IN cytoplasm (inferred); eukaryotic translation initiation factor 4F complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: eukaryotic translation initiation factor 4E type 1B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,695,229 - 36,701,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,695,107 - 36,699,254 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha436,662,968 - 36,668,831 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,062,269 - 37,068,139 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,062,269 - 37,065,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,888,158 - 36,893,997 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,075,821 - 37,081,660 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0437,584,094 - 37,587,313 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EIF4E1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,695,229 - 36,701,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,695,107 - 36,699,254 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha436,662,968 - 36,668,831 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,062,269 - 37,068,139 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,062,269 - 37,065,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,888,158 - 36,893,997 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,075,821 - 37,081,660 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0437,584,094 - 37,587,313 (-)NCBIUU_Cfam_GSD_1.0
EIF4E1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385176,630,675 - 176,646,644 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5176,630,618 - 176,646,644 (+)EnsemblGRCh38hg38GRCh38
GRCh375176,057,676 - 176,073,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365175,990,289 - 176,006,248 (+)NCBINCBI36Build 36hg18NCBI36
Celera5172,426,610 - 172,442,576 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5170,981,382 - 170,997,656 (+)NCBIHuRef
CHM1_15175,490,107 - 175,506,076 (+)NCBICHM1_1
T2T-CHM13v2.05177,177,255 - 177,193,232 (+)NCBIT2T-CHM13v2.0
Eif4e1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,931,807 - 54,936,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,931,811 - 54,936,272 (+)EnsemblGRCm39 Ensembl
GRCm381354,783,994 - 54,788,459 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,783,998 - 54,788,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv371354,885,364 - 54,889,820 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,263,159 - 54,266,201 (+)NCBIMGSCv36mm8
MGSCv361354,793,635 - 54,798,073 (+)NCBIMGSCv36mm8
Cytogenetic Map13B1NCBI
cM Map1329.39NCBI
Eif4e1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,835,883 - 9,868,781 (-)NCBIGRCr8
mRatBN7.2179,831,338 - 9,856,250 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,832,230 - 9,835,137 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01710,369,153 - 10,391,667 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01712,495,105 - 12,518,891 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,892,927 - 15,904,867 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera179,906,566 - 9,929,057 (-)NCBICelera
Cytogenetic Map17p14NCBI
Eif4e1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,910,141 - 28,913,692 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,910,141 - 28,913,692 (+)NCBIChiLan1.0ChiLan1.0
EIF4E1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24171,723,454 - 171,727,136 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15169,862,997 - 169,866,675 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05171,941,013 - 171,944,691 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15178,998,930 - 179,014,809 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,010,207 - 179,014,809 (+)Ensemblpanpan1.1panPan2
Eif4e1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213121,863,445 - 121,875,777 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936597896,952 - 899,691 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936597898,012 - 900,677 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4E1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl281,277,952 - 81,281,453 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1281,277,086 - 81,281,668 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2282,879,022 - 82,883,311 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4E1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12378,650,378 - 78,653,912 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2378,650,330 - 78,653,524 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660759,807,894 - 9,811,122 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif4e1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473313,476,389 - 13,489,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EIF4E1B
70 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1
Below cutoff 5 5 20 4 6 4 6 5 12 8 10 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026360   ⟹   ENSCAFP00000024482
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl436,695,107 - 36,699,254 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845021527   ⟹   ENSCAFP00845016917
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl437,062,269 - 37,065,368 (-)Ensembl
RefSeq Acc Id: XM_022417990   ⟹   XP_022273698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1436,695,229 - 36,701,988 (-)NCBI
Dog10K_Boxer_Tasha436,662,968 - 36,668,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038474324   ⟹   XP_038330252
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1436,888,158 - 36,893,997 (-)NCBI
RefSeq Acc Id: XM_038535452   ⟹   XP_038391380
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0437,584,094 - 37,587,313 (-)NCBI
RefSeq Acc Id: XM_038598065   ⟹   XP_038453993
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0437,075,821 - 37,081,660 (-)NCBI
RefSeq Acc Id: XM_038662372   ⟹   XP_038518300
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0437,062,269 - 37,068,139 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022273698   ⟸   XM_022417990
- Peptide Label: isoform X1
- UniProtKB: A0A8C0M5F6 (UniProtKB/TrEMBL),   A0A8I3NKV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024482   ⟸   ENSCAFT00000026360
RefSeq Acc Id: XP_038330252   ⟸   XM_038474324
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038453993   ⟸   XM_038598065
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038518300   ⟸   XM_038662372
- Peptide Label: isoform X1
- UniProtKB: A0A8C0M5F6 (UniProtKB/TrEMBL),   A0A8I3NKV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391380   ⟸   XM_038535452
- Peptide Label: isoform X2
- UniProtKB: A0A8C0M5F6 (UniProtKB/TrEMBL),   A0A8I3NKV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845016917   ⟸   ENSCAFT00845021527


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016643 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002558 UniProtKB/TrEMBL
  ENSCAFG00040017239 UniProtKB/TrEMBL
  ENSCAFG00845012098 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026360.5 UniProtKB/TrEMBL
  ENSCAFT00000100853.1 UniProtKB/TrEMBL
  ENSCAFT00030004722.1 UniProtKB/TrEMBL
  ENSCAFT00040031922.1 UniProtKB/TrEMBL
  ENSCAFT00845021527 ENTREZGENE
  ENSCAFT00845021527.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.760.10 UniProtKB/TrEMBL
InterPro TIF_eIF4e-like UniProtKB/TrEMBL
  TIF_eIF_4E UniProtKB/TrEMBL
  TIF_eIF_4E_CS UniProtKB/TrEMBL
NCBI Gene EIF4E1B ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 1B UniProtKB/TrEMBL
  PTHR11960 UniProtKB/TrEMBL
Pfam IF4E UniProtKB/TrEMBL
PROSITE IF4E UniProtKB/TrEMBL
Superfamily-SCOP SSF55418 UniProtKB/TrEMBL
UniProt A0A8C0M5F6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NKV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NI40_CANLF UniProtKB/TrEMBL
  A0A8P0PGF9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40284 ENTREZGENE