MEDAG (mesenteric estrogen dependent adipogenesis) - Rat Genome Database

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Gene: MEDAG (mesenteric estrogen dependent adipogenesis) Canis lupus familiaris
Analyze
Symbol: MEDAG
Name: mesenteric estrogen dependent adipogenesis
RGD ID: 12206646
Description: INVOLVED IN positive regulation of fat cell differentiation (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C25H13orf33
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,182,441 - 9,201,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,183,443 - 9,200,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha259,224,982 - 9,242,610 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,287,047 - 9,305,980 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,287,076 - 9,304,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,185,976 - 9,203,593 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0259,194,040 - 9,211,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,236,109 - 9,253,732 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MEDAG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,182,441 - 9,201,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,183,443 - 9,200,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha259,224,982 - 9,242,610 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,287,047 - 9,305,980 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,287,076 - 9,304,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,185,976 - 9,203,593 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0259,194,040 - 9,211,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,236,109 - 9,253,732 (-)NCBIUU_Cfam_GSD_1.0
MEDAG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,906,271 - 30,925,572 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1330,906,271 - 30,925,572 (+)EnsemblGRCh38hg38GRCh38
GRCh371331,480,408 - 31,499,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,378,328 - 30,397,678 (+)NCBINCBI36Build 36hg18NCBI36
Celera1312,546,863 - 12,566,248 (+)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1312,291,191 - 12,310,577 (+)NCBIHuRef
CHM1_11331,447,426 - 31,466,813 (+)NCBICHM1_1
T2T-CHM13v2.01330,128,196 - 30,147,488 (+)NCBIT2T-CHM13v2.0
Medag
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,335,214 - 149,355,188 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,335,214 - 149,355,188 (+)EnsemblGRCm39 Ensembl
GRCm385149,367,641 - 149,431,723 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,411,749 - 149,431,723 (+)EnsemblGRCm38mm10GRCm38
MGSCv375150,214,381 - 150,234,278 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365149,680,185 - 149,700,082 (+)NCBIMGSCv36mm8
Celera5147,412,123 - 147,432,091 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Medag
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,649,526 - 10,670,913 (-)NCBIGRCr8
mRatBN7.2125,613,191 - 5,634,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,613,208 - 5,634,767 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,279,708 - 6,300,994 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,903,180 - 6,924,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0125,930,909 - 5,952,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,711,745 - 6,730,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,711,747 - 6,740,714 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,808,629 - 8,828,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4126,104,957 - 6,126,628 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1126,104,981 - 6,126,628 (-)NCBI
Celera127,371,986 - 7,393,743 (-)NCBICelera
Cytogenetic Map12p11NCBI
Medag
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543114,916,369 - 14,937,385 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543114,918,560 - 14,937,385 (-)NCBIChiLan1.0ChiLan1.0
MEDAG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,487,042 - 30,506,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,593,822 - 21,613,941 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,180,622 - 12,200,123 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,614,989 - 30,634,048 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,614,989 - 30,632,912 (+)Ensemblpanpan1.1panPan2
Medag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,298,447 - 170,317,740 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,634,349 - 25,653,823 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,634,444 - 25,653,708 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEDAG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl117,545,494 - 7,562,737 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1117,545,400 - 7,562,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,396,838 - 7,414,378 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEDAG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,779,644 - 9,799,113 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605734,569,194 - 34,588,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Medag
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,278,545 - 7,300,602 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247767,280,321 - 7,300,505 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MEDAG
229 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 1 14 6 9 9 6
Low 2 4 2 6 6 3 5 1
Below cutoff 6 6 6 3

Sequence


RefSeq Acc Id: ENSCAFT00000010612   ⟹   ENSCAFP00000009838
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl259,183,443 - 9,200,051 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845038347   ⟹   ENSCAFP00845030021
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl259,287,076 - 9,304,969 (-)Ensembl
RefSeq Acc Id: XM_014107343   ⟹   XP_013962818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1259,182,441 - 9,201,235 (-)NCBI
Dog10K_Boxer_Tasha259,224,982 - 9,242,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038434669   ⟹   XP_038290597
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0259,287,047 - 9,305,980 (-)NCBI
RefSeq Acc Id: XM_038511004   ⟹   XP_038366932
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1259,185,976 - 9,203,593 (-)NCBI
RefSeq Acc Id: XM_038574491   ⟹   XP_038430419
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0259,236,109 - 9,253,732 (-)NCBI
RefSeq Acc Id: XM_038637351   ⟹   XP_038493279
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0259,194,040 - 9,211,661 (-)NCBI
RefSeq Acc Id: XP_013962818   ⟸   XM_014107343
- Peptide Label: isoform X5
- UniProtKB: A0A8C0SU14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000009838   ⟸   ENSCAFT00000010612
RefSeq Acc Id: XP_038366932   ⟸   XM_038511004
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038493279   ⟸   XM_038637351
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038290597   ⟸   XM_038434669
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038430419   ⟸   XM_038574491
- Peptide Label: isoform X4
- UniProtKB: A0A8C0SU14 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845030021   ⟸   ENSCAFT00845038347

Promoters
RGD ID:13687718
Promoter ID:EPDNEW_C5785
Type:initiation region
Name:MEDAG_1
Description:mesenteric estrogen dependent adipogenesis
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1259,199,990 - 9,200,050EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006579 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040016605 UniProtKB/TrEMBL
  ENSCAFG00845021735 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010612.5 UniProtKB/TrEMBL
  ENSCAFT00040030652.1 UniProtKB/TrEMBL
  ENSCAFT00845038347.1 UniProtKB/TrEMBL
InterPro MEDAG/TEX26 UniProtKB/TrEMBL
NCBI Gene MEDAG ENTREZGENE
PANTHER PTHR33769 UniProtKB/TrEMBL
  PTHR33769:SF3 UniProtKB/TrEMBL
UniProt A0A8C0SU14 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PHK4_CANLF UniProtKB/TrEMBL
  A0A8P0SBX2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:58315 ENTREZGENE