PTPN6 (protein tyrosine phosphatase non-receptor type 6) - Rat Genome Database

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Gene: PTPN6 (protein tyrosine phosphatase non-receptor type 6) Canis lupus familiaris
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Symbol: PTPN6
Name: protein tyrosine phosphatase non-receptor type 6
RGD ID: 12204471
Description: ENCODES a protein that exhibits cytokine receptor binding (ortholog); natural killer cell lectin-like receptor binding (ortholog); INVOLVED IN B cell receptor signaling pathway (ortholog); cellular response to macrophage colony-stimulating factor stimulus (ortholog); hematopoietic progenitor cell differentiation (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH anogenital venereal wart (ortholog); autism spectrum disorder (ortholog); calcinosis (ortholog); FOUND IN apical dendrite (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dentatorubro-pallidoluysian atrophy protein; DRPLA; tyrosine-protein phosphatase non-receptor type 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,084,976 - 38,101,552 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,084,980 - 38,101,937 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,519,708 - 8,531,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,437,567 - 38,449,584 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,437,569 - 38,453,615 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,312,457 - 38,324,047 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,353,429 - 38,365,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,998,465 - 8,010,486 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell receptor signaling pathway  (IEA,ISO)
cell differentiation  (IEA)
cellular response to macrophage colony-stimulating factor stimulus  (ISO)
cellular response to organic substance  (IEA)
epididymis development  (IEA)
hematopoietic progenitor cell differentiation  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
MAPK cascade  (IEA,ISO)
megakaryocyte development  (IEA,ISO)
mitotic cell cycle  (IEA)
natural killer cell mediated cytotoxicity  (IEA,ISO)
negative regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
negative regulation of inflammatory response to wounding  (IEA)
negative regulation of interleukin-6 production  (IEA)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of mast cell activation involved in immune response  (IEA)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of T cell receptor signaling pathway  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA)
platelet aggregation  (IEA,ISO)
platelet formation  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
regulation of B cell differentiation  (IEA,ISO)
regulation of ERK1 and ERK2 cascade  (IEA)
regulation of G1/S transition of mitotic cell cycle  (IEA)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
response to axon injury  (ISO)
T cell proliferation  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PTPN6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,084,976 - 38,101,552 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,084,980 - 38,101,937 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,519,708 - 8,531,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,437,567 - 38,449,584 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,437,569 - 38,453,615 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,312,457 - 38,324,047 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,353,429 - 38,365,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,998,465 - 8,010,486 (+)NCBIUU_Cfam_GSD_1.0
PTPN6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,946,577 - 6,961,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,946,468 - 6,961,316 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,055,740 - 7,070,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,926,001 - 6,940,740 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,930,762 - 6,940,740NCBI
Celera128,674,361 - 8,691,497 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,911,844 - 6,928,943 (+)NCBIHuRef
CHM1_1127,054,727 - 7,069,431 (+)NCBICHM1_1
T2T-CHM13v2.0126,957,743 - 6,974,790 (+)NCBIT2T-CHM13v2.0
Ptpn6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,697,670 - 124,715,672 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,697,670 - 124,715,677 (-)EnsemblGRCm39 Ensembl
GRCm386124,720,707 - 124,738,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,720,707 - 124,738,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,670,736 - 124,688,727 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,686,336 - 124,698,725 (-)NCBIMGSCv36mm8
Celera6126,402,447 - 126,420,442 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Ptpn6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,212,320 - 159,237,069 (-)NCBIGRCr8
mRatBN7.24157,526,034 - 157,550,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,526,035 - 157,550,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,754,524 - 163,773,000 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,537,429 - 159,555,906 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,178,993 - 158,197,490 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,239,141 - 157,263,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,239,142 - 157,263,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,256,737 - 224,281,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,843,699 - 160,868,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,088,634 - 161,113,792 (-)NCBI
Celera4146,264,696 - 146,289,049 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ptpn6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,525,954 - 4,547,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,525,954 - 4,547,177 (+)NCBIChiLan1.0ChiLan1.0
PTPN6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,510,113 - 12,527,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,506,872 - 12,524,068 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,075,879 - 7,093,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,991,099 - 7,008,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,991,099 - 7,008,830 (+)Ensemblpanpan1.1panPan2
Ptpn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,196,659 - 102,217,158 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709864,197 - 884,610 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709864,206 - 884,630 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,762,112 - 63,808,350 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,762,109 - 63,779,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,198,250 - 66,215,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,977,480 - 6,994,525 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,984,710 - 6,994,545 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,223,213 - 1,240,430 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,580,560 - 3,595,090 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,580,225 - 3,595,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTPN6
174 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 8 6 4 6 7 4
Low 2 5 14 6 6 2 6 6 8 3 2
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000022979   ⟹   ENSCAFP00000021345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,084,980 - 38,096,934 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063043   ⟹   ENSCAFP00000063865
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,084,980 - 38,096,676 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063780   ⟹   ENSCAFP00000043746
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,084,980 - 38,096,676 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000088995   ⟹   ENSCAFP00000053940
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2738,084,980 - 38,101,937 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046115   ⟹   ENSCAFP00845036208
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2738,437,569 - 38,453,615 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046226   ⟹   ENSCAFP00845036300
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2738,437,569 - 38,449,577 (-)Ensembl
RefSeq Acc Id: XM_005637211   ⟹   XP_005637268
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12738,084,976 - 38,096,996 (-)NCBI
Dog10K_Boxer_Tasha278,519,708 - 8,531,714 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038439139   ⟹   XP_038295067
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02738,437,567 - 38,449,584 (-)NCBI
RefSeq Acc Id: XM_038513801   ⟹   XP_038369729
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12738,312,457 - 38,324,047 (-)NCBI
RefSeq Acc Id: XM_038576637   ⟹   XP_038432565
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0277,998,465 - 8,010,486 (+)NCBI
RefSeq Acc Id: XM_038641640   ⟹   XP_038497568
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02738,353,429 - 38,365,020 (-)NCBI
RefSeq Acc Id: XP_005637268   ⟸   XM_005637211
- UniProtKB: A0A8C0JNN8 (UniProtKB/TrEMBL),   A0A8C0TL66 (UniProtKB/TrEMBL),   A0A8I3S5S9 (UniProtKB/TrEMBL),   A0A8C0JRA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053940   ⟸   ENSCAFT00000088995
RefSeq Acc Id: ENSCAFP00000063865   ⟸   ENSCAFT00000063043
RefSeq Acc Id: ENSCAFP00000043746   ⟸   ENSCAFT00000063780
RefSeq Acc Id: ENSCAFP00000021345   ⟸   ENSCAFT00000022979
RefSeq Acc Id: XP_038369729   ⟸   XM_038513801
RefSeq Acc Id: XP_038497568   ⟸   XM_038641640
RefSeq Acc Id: XP_038295067   ⟸   XM_038439139
- UniProtKB: A0A8C0JNN8 (UniProtKB/TrEMBL),   A0A8C0TL66 (UniProtKB/TrEMBL),   A0A8I3S5S9 (UniProtKB/TrEMBL),   A0A8C0JRA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432565   ⟸   XM_038576637
- UniProtKB: A0A8C0JNN8 (UniProtKB/TrEMBL),   A0A8C0JRA1 (UniProtKB/TrEMBL),   A0A8C0TL66 (UniProtKB/TrEMBL),   A0A8I3S5S9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845036208   ⟸   ENSCAFT00845046115
RefSeq Acc Id: ENSCAFP00845036300   ⟸   ENSCAFT00845046226

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014463 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021015 UniProtKB/TrEMBL
  ENSCAFG00040023316 UniProtKB/TrEMBL
  ENSCAFG00845026107 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022979.5 UniProtKB/TrEMBL
  ENSCAFT00000088995.2 UniProtKB/TrEMBL
  ENSCAFT00030038591.1 UniProtKB/TrEMBL
  ENSCAFT00030038688.1 UniProtKB/TrEMBL
  ENSCAFT00030038787.1 UniProtKB/TrEMBL
  ENSCAFT00040043440.1 UniProtKB/TrEMBL
  ENSCAFT00040043470.1 UniProtKB/TrEMBL
  ENSCAFT00040043550.1 UniProtKB/TrEMBL
  ENSCAFT00040043613.1 UniProtKB/TrEMBL
  ENSCAFT00040043656.1 UniProtKB/TrEMBL
  ENSCAFT00845046115.1 UniProtKB/TrEMBL
  ENSCAFT00845046226 ENTREZGENE
  ENSCAFT00845046226.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-6/11 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
KEGG Report cfa:486717 UniProtKB/TrEMBL
NCBI Gene PTPN6 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE CORKSCREW UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF Tyr-Ptase_nr_6 UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8C0JNN8 ENTREZGENE
  A0A8C0JRA1 ENTREZGENE
  A0A8C0NZW1_CANLF UniProtKB/TrEMBL
  A0A8C0PA14_CANLF UniProtKB/TrEMBL
  A0A8C0TL66 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TLK3_CANLF UniProtKB/TrEMBL
  A0A8C0Z5B7_CANLF UniProtKB/TrEMBL
  A0A8I3PWC6_CANLF UniProtKB/TrEMBL
  A0A8I3S5S9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45179 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 PTPN6  protein tyrosine phosphatase non-receptor type 6    protein tyrosine phosphatase, non-receptor type 6  Symbol and/or name change 5135510 APPROVED