SLC5A2 (solute carrier family 5 member 2) - Rat Genome Database

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Gene: SLC5A2 (solute carrier family 5 member 2) Canis lupus familiaris
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Symbol: SLC5A2
Name: solute carrier family 5 member 2
RGD ID: 12204028
Description: ENCODES a protein that exhibits alpha-glucoside transmembrane transporter activity (ortholog); D-glucose transmembrane transporter activity (ortholog); glucose:sodium symporter activity (ortholog); INVOLVED IN alpha-glucoside transport (ortholog); glucose import across plasma membrane (ortholog); glucose transmembrane transport (ortholog); PARTICIPATES IN sodium-glucose cotransporter mediated glucose transport pathway; ASSOCIATED WITH branched-chain keto acid dehydrogenase kinase deficiency (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SGLT2; sodium-glucose cotransporter-like 2; sodium/glucose cotransporter 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,765,935 - 16,772,145 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,765,938 - 16,772,137 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,393,645 - 18,399,844 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,890,717 - 16,896,969 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,890,717 - 16,905,803 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,694,325 - 16,700,565 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,614,024 - 16,620,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,925,700 - 16,931,900 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC5A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,765,935 - 16,772,145 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,765,938 - 16,772,137 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,393,645 - 18,399,844 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,890,717 - 16,896,969 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,890,717 - 16,905,803 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,694,325 - 16,700,565 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,614,024 - 16,620,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,925,700 - 16,931,900 (-)NCBIUU_Cfam_GSD_1.0
SLC5A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,483,123 - 31,490,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,483,002 - 31,490,860 (+)EnsemblGRCh38hg38GRCh38
GRCh371631,494,444 - 31,502,090 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,401,940 - 31,409,590 (+)NCBINCBI36Build 36hg18NCBI36
Build 341631,401,939 - 31,409,590NCBI
Celera1628,806,298 - 28,813,953 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1629,054,639 - 29,062,297 (+)NCBIHuRef
CHM1_11632,813,088 - 32,820,740 (+)NCBICHM1_1
T2T-CHM13v2.01631,870,510 - 31,878,162 (+)NCBIT2T-CHM13v2.0
Slc5a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,864,855 - 127,871,602 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,864,829 - 127,871,602 (+)EnsemblGRCm39 Ensembl
GRCm387128,265,683 - 128,272,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,265,657 - 128,272,430 (+)EnsemblGRCm38mm10GRCm38
MGSCv377135,409,211 - 135,415,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367128,056,845 - 128,063,581 (+)NCBIMGSCv36mm8
Celera7128,101,772 - 128,108,508 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map770.08NCBI
Slc5a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,277,621 - 192,283,742 (+)NCBIGRCr8
mRatBN7.21182,847,185 - 182,853,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,847,106 - 182,853,306 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,197,664 - 191,203,785 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,383,752 - 198,389,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,053,939 - 191,060,060 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,682,688 - 199,688,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,682,688 - 199,688,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,728,635 - 206,734,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,523,230 - 187,529,351 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,673,110 - 187,679,232 (+)NCBI
Celera1180,493,106 - 180,499,226 (+)NCBICelera
Cytogenetic Map1q37NCBI
Slc5a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554938,322,597 - 8,329,646 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554938,322,972 - 8,329,886 (+)NCBIChiLan1.0ChiLan1.0
SLC5A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,692,678 - 34,699,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,494,547 - 39,501,343 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,474,992 - 23,482,603 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,853,610 - 31,861,261 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,853,602 - 31,861,261 (+)Ensemblpanpan1.1panPan2
Slc5a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,693,244 - 125,699,926 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365438,336,873 - 8,343,322 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365438,336,884 - 8,343,322 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC5A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,081,141 - 17,089,568 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,081,138 - 17,089,422 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,348,680 - 17,354,123 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC5A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1528,183,141 - 28,191,352 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl528,183,618 - 28,191,120 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,248,831 - 1,257,049 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc5a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,483,822 - 14,490,841 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,484,532 - 14,490,598 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC5A2
96 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 4 1 16 5 6 7 2 10 6
Below cutoff 1 4 6 6 1 6 6 5 6

Sequence


RefSeq Acc Id: ENSCAFT00000026790   ⟹   ENSCAFP00000024893
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl616,765,938 - 16,772,137 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018627   ⟹   ENSCAFP00845014534
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,890,717 - 16,905,803 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018717   ⟹   ENSCAFP00845014612
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,890,717 - 16,905,803 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018860   ⟹   ENSCAFP00845014734
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,890,717 - 16,896,957 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018966   ⟹   ENSCAFP00845014816
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,890,717 - 16,896,957 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019004   ⟹   ENSCAFP00845014846
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,900,264 - 16,905,803 (-)Ensembl
RefSeq Acc Id: NM_001007142   ⟹   NP_001007143
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1616,765,938 - 16,772,137 (-)NCBI
Dog10K_Boxer_Tasha618,393,645 - 18,399,844 (+)NCBI
ROS_Cfam_1.0616,890,717 - 16,896,957 (-)NCBI
UMICH_Zoey_3.1616,694,325 - 16,700,565 (-)NCBI
UNSW_CanFamBas_1.0616,614,024 - 16,620,201 (-)NCBI
UU_Cfam_GSD_1.0616,925,700 - 16,931,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038667634   ⟹   XP_038523562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0616,890,717 - 16,896,969 (-)NCBI
RefSeq Acc Id: NP_001007143   ⟸   NM_001007142
- UniProtKB: A0A8C0L818 (UniProtKB/TrEMBL),   A0A8C0YT22 (UniProtKB/TrEMBL),   A0A8I3NI32 (UniProtKB/TrEMBL),   A0A8I3NB37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024893   ⟸   ENSCAFT00000026790
RefSeq Acc Id: XP_038523562   ⟸   XM_038667634
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NB37 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014534   ⟸   ENSCAFT00845018627
RefSeq Acc Id: ENSCAFP00845014612   ⟸   ENSCAFT00845018717
RefSeq Acc Id: ENSCAFP00845014734   ⟸   ENSCAFT00845018860
RefSeq Acc Id: ENSCAFP00845014816   ⟸   ENSCAFT00845018966
RefSeq Acc Id: ENSCAFP00845014846   ⟸   ENSCAFT00845019004
Protein Domains
LIM zinc-binding

Promoters
RGD ID:13683597
Promoter ID:EPDNEW_C1665
Type:multiple initiation site
Name:SLC5A2_1
Description:solute carrier family 5 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1616,772,126 - 16,772,186EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016909 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004133 UniProtKB/TrEMBL
  ENSCAFG00040009522 UniProtKB/TrEMBL
  ENSCAFG00845010573 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026790.4 UniProtKB/TrEMBL
  ENSCAFT00030007623.1 UniProtKB/TrEMBL
  ENSCAFT00040017719.1 UniProtKB/TrEMBL
  ENSCAFT00845018627.1 UniProtKB/TrEMBL
  ENSCAFT00845018717.1 UniProtKB/TrEMBL
  ENSCAFT00845018860 ENTREZGENE
  ENSCAFT00845018860.1 UniProtKB/TrEMBL
  ENSCAFT00845018966.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1730.10 UniProtKB/TrEMBL
  Cysteine Rich Protein UniProtKB/TrEMBL
InterPro Na/Glc_symporter_sf UniProtKB/TrEMBL
  Na/solute_symporter UniProtKB/TrEMBL
  Na/solute_symporter_CS UniProtKB/TrEMBL
  Paxillin_TGFB1I1_LIM_dom1 UniProtKB/TrEMBL
  Znf_LIM UniProtKB/TrEMBL
KEGG Report cfa:492301 UniProtKB/TrEMBL
NCBI Gene SLC5A2 ENTREZGENE
PANTHER SODIUM/GLUCOSE COTRANSPORTER 2 UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 5 UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
  Paxillin UniProtKB/TrEMBL
  SSF UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
  NA_SOLUT_SYMP_1 UniProtKB/TrEMBL
  NA_SOLUT_SYMP_2 UniProtKB/TrEMBL
  NA_SOLUT_SYMP_3 UniProtKB/TrEMBL
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A8C0L818 ENTREZGENE
  A0A8C0YT22 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N687_CANLF UniProtKB/TrEMBL
  A0A8I3NB37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NDP7_CANLF UniProtKB/TrEMBL
  A0A8I3NI32 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46446 ENTREZGENE