CARD10 (caspase recruitment domain family member 10) - Rat Genome Database

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Gene: CARD10 (caspase recruitment domain family member 10) Canis lupus familiaris
Analyze
Symbol: CARD10
Name: caspase recruitment domain family member 10
RGD ID: 12203987
Description: ENCODES a protein that exhibits CARD domain binding (inferred); INVOLVED IN negative regulation of cell migration involved in sprouting angiogenesis (inferred); positive regulation of protein localization to nucleus (inferred); regulation of apoptotic process (inferred); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase recruitment domain-containing protein 10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,055,293 - 27,080,109 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,053,915 - 27,079,341 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,008,755 - 27,034,511 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,846,054 - 27,871,811 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,845,644 - 27,871,807 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,567,955 - 27,593,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,876,590 - 27,902,328 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,054,334 - 28,080,088 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
CARD10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,055,293 - 27,080,109 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,053,915 - 27,079,341 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,008,755 - 27,034,511 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,846,054 - 27,871,811 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,845,644 - 27,871,807 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,567,955 - 27,593,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,876,590 - 27,902,328 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,054,334 - 28,080,088 (+)NCBIUU_Cfam_GSD_1.0
CARD10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,490,362 - 37,519,415 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,490,362 - 37,519,542 (-)EnsemblGRCh38hg38GRCh38
GRCh372237,886,400 - 37,915,422 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,216,346 - 36,245,156 (-)NCBINCBI36Build 36hg18NCBI36
Build 342236,210,900 - 36,239,710NCBI
Celera2221,687,204 - 21,715,894 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2220,852,627 - 20,881,868 (-)NCBIHuRef
CHM1_12237,845,198 - 37,873,529 (-)NCBICHM1_1
T2T-CHM13v2.02237,951,227 - 37,980,107 (-)NCBIT2T-CHM13v2.0
Card10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,659,323 - 78,687,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,659,338 - 78,687,242 (-)EnsemblGRCm39 Ensembl
GRCm381578,775,123 - 78,803,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,775,138 - 78,803,042 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,605,566 - 78,633,472 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,602,391 - 78,630,297 (-)NCBIMGSCv36mm8
Celera1580,230,970 - 80,251,729 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
Card10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,210,944 - 112,252,044 (-)NCBIGRCr8
mRatBN7.27110,330,460 - 110,371,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,330,408 - 110,359,224 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,081,981 - 112,109,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,305,511 - 114,332,931 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,273,289 - 114,301,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,998,639 - 120,028,632 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,999,472 - 120,027,026 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,990,231 - 120,020,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,737,928 - 116,766,959 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17116,772,155 - 116,838,884 (-)NCBI
Celera7106,667,220 - 106,693,633 (-)NCBICelera
Cytogenetic Map7q34NCBI
Card10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,920,405 - 23,946,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,920,929 - 23,946,109 (-)NCBIChiLan1.0ChiLan1.0
CARD10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,349,856 - 47,381,343 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,038,456 - 50,069,942 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,407,374 - 18,437,728 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,240,101 - 36,268,565 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,240,898 - 36,268,546 (-)Ensemblpanpan1.1panPan2
Card10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,509,715 - 10,534,764 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,522,533 - 3,545,279 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,520,129 - 3,545,178 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CARD10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,284,139 - 10,316,720 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,290,697 - 10,317,224 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CARD10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,198,093 - 20,227,523 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1920,198,878 - 20,227,321 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045105,599,686 - 105,630,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Card10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,366,653 - 10,390,957 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475210,366,698 - 10,390,799 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CARD10
240 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 5 6
Low 5 4 22 6 6 6 6 6 12 8 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022424468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000044904   ⟹   ENSCAFP00000037602
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1027,053,915 - 27,079,341 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845011376   ⟹   ENSCAFP00845008885
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1027,845,644 - 27,871,807 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845011464   ⟹   ENSCAFP00845008955
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1027,845,644 - 27,871,807 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845011755   ⟹   ENSCAFP00845009175
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1027,845,644 - 27,871,807 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012018   ⟹   ENSCAFP00845009378
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1027,846,528 - 27,871,807 (+)Ensembl
RefSeq Acc Id: XM_038488689   ⟹   XP_038344617
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11027,568,700 - 27,593,683 (+)NCBI
RefSeq Acc Id: XM_038488690   ⟹   XP_038344618
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11027,567,955 - 27,593,683 (+)NCBI
RefSeq Acc Id: XM_038550650   ⟹   XP_038406578
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01028,055,078 - 28,080,088 (+)NCBI
RefSeq Acc Id: XM_038550651   ⟹   XP_038406579
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01028,054,334 - 28,080,088 (+)NCBI
RefSeq Acc Id: XM_038614585   ⟹   XP_038470513
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01027,877,333 - 27,902,328 (+)NCBI
RefSeq Acc Id: XM_038614586   ⟹   XP_038470514
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01027,876,590 - 27,902,328 (+)NCBI
RefSeq Acc Id: XM_038640297   ⟹   XP_038496225
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1027,009,499 - 27,034,511 (+)NCBI
RefSeq Acc Id: XM_038640298   ⟹   XP_038496226
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1027,008,755 - 27,034,511 (+)NCBI
RefSeq Acc Id: XM_038679945   ⟹   XP_038535873
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01027,846,798 - 27,871,811 (+)NCBI
RefSeq Acc Id: XM_038679946   ⟹   XP_038535874
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01027,846,054 - 27,871,811 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000037602   ⟸   ENSCAFT00000044904
RefSeq Acc Id: XP_038344618   ⟸   XM_038488690
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038344617   ⟸   XM_038488689
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470514   ⟸   XM_038614586
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038470513   ⟸   XM_038614585
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038535874   ⟸   XM_038679946
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JRW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038535873   ⟸   XM_038679945
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JRW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038496226   ⟸   XM_038640298
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JRW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038496225   ⟸   XM_038640297
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JRW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406579   ⟸   XM_038550651
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JRW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406578   ⟸   XM_038550650
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JRW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845009378   ⟸   ENSCAFT00845012018
RefSeq Acc Id: ENSCAFP00845008955   ⟸   ENSCAFT00845011464
RefSeq Acc Id: ENSCAFP00845009175   ⟸   ENSCAFT00845011755
RefSeq Acc Id: ENSCAFP00845008885   ⟸   ENSCAFT00845011376
Protein Domains
CARD

Promoters
RGD ID:13684984
Promoter ID:EPDNEW_C3052
Type:single initiation site
Name:CARD10_1
Description:caspase recruitment domain family member 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11027,055,322 - 27,055,382EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001502 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009816 UniProtKB/TrEMBL
  ENSCAFG00845006362 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000044904.4 UniProtKB/TrEMBL
  ENSCAFT00000098143.1 UniProtKB/TrEMBL
  ENSCAFT00000105967.1 UniProtKB/TrEMBL
  ENSCAFT00030018892.1 UniProtKB/TrEMBL
  ENSCAFT00845011376.1 UniProtKB/TrEMBL
  ENSCAFT00845011464.1 UniProtKB/TrEMBL
  ENSCAFT00845011755 ENTREZGENE
  ENSCAFT00845011755.1 UniProtKB/TrEMBL
  ENSCAFT00845012018 ENTREZGENE
  ENSCAFT00845012018.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD_CARD10 UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene CARD10 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN FAMILY UniProtKB/TrEMBL
  CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 10 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A8C0JRW6 ENTREZGENE
  A0A8C0N6F5_CANLF UniProtKB/TrEMBL
  A0A8I3MVE1_CANLF UniProtKB/TrEMBL
  A0A8I3MXQ7_CANLF UniProtKB/TrEMBL
  A0A8I3N3D3_CANLF UniProtKB/TrEMBL
  A0A8I3RUS2_CANLF UniProtKB/TrEMBL
  A0A8P0PQF8_CANLF UniProtKB/TrEMBL
  A0A8P0TRS3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38713 ENTREZGENE