ZFP36L1 (ZFP36 ring finger protein like 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ZFP36L1 (ZFP36 ring finger protein like 1) Canis lupus familiaris
Analyze
Symbol: ZFP36L1
Name: ZFP36 ring finger protein like 1
RGD ID: 12202643
Description: ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); INVOLVED IN apoptotic process (ortholog); cell population proliferation (ortholog); chorio-allantoic fusion (ortholog); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mRNA decay activator protein ZFP36L1; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H1 type-like 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,663,287 - 42,668,665 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,664,223 - 42,668,514 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha842,352,777 - 42,358,311 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0842,893,323 - 42,898,832 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl842,893,325 - 42,898,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,507,658 - 42,513,193 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,582,437 - 42,587,961 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0842,941,809 - 42,947,345 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (IEA)
apoptotic process  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to cAMP  (IEA)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to fibroblast growth factor stimulus  (IEA)
cellular response to glucocorticoid stimulus  (IEA)
cellular response to hypoxia  (IEA)
cellular response to insulin stimulus  (IEA)
cellular response to peptide hormone stimulus  (IEA)
cellular response to raffinose  (IEA)
cellular response to salt stress  (IEA)
cellular response to transforming growth factor beta stimulus  (IEA)
cellular response to tumor necrosis factor  (IEA)
chorio-allantoic fusion  (IEA,ISO)
embryonic organ development  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA)
heart development  (IEA,ISO)
MAPK cascade  (IEA)
mesendoderm development  (IEA)
mRNA catabolic process  (ISO)
mRNA transport  (IEA)
multicellular organism growth  (IEA,ISO)
negative regulation of erythrocyte differentiation  (IEA)
negative regulation of mitotic cell cycle phase transition  (IEA)
neural tube development  (IEA,ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  (ISO)
p38MAPK cascade  (IEA)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of fat cell differentiation  (IEA)
positive regulation of intracellular mRNA localization  (IEA)
positive regulation of monocyte differentiation  (IEA)
positive regulation of mRNA catabolic process  (IEA)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA)
proepicardium development  (IEA,ISO)
regulation of B cell differentiation  (IEA)
regulation of gene expression  (IEA)
regulation of keratinocyte apoptotic process  (IEA)
regulation of keratinocyte differentiation  (IEA)
regulation of keratinocyte proliferation  (IEA)
regulation of mRNA 3'-end processing  (IEA)
regulation of mRNA stability  (IEA,ISO)
regulation of myoblast differentiation  (IEA)
regulation of stem cell proliferation  (IEA)
regulation of translation  (IEA,ISO)
response to wounding  (IEA)
spongiotrophoblast layer development  (IEA,ISO)
T cell differentiation in thymus  (IEA)
vasculogenesis  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ZFP36L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,663,287 - 42,668,665 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,664,223 - 42,668,514 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha842,352,777 - 42,358,311 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0842,893,323 - 42,898,832 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl842,893,325 - 42,898,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,507,658 - 42,513,193 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,582,437 - 42,587,961 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0842,941,809 - 42,947,345 (-)NCBIUU_Cfam_GSD_1.0
ZFP36L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381468,787,655 - 68,796,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1468,787,660 - 68,796,253 (-)EnsemblGRCh38hg38GRCh38
GRCh371469,254,372 - 69,262,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,324,128 - 68,329,538 (-)NCBINCBI36Build 36hg18NCBI36
Build 341468,324,127 - 68,329,538NCBI
Celera1449,313,123 - 49,318,532 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1449,422,410 - 49,430,997 (-)NCBIHuRef
CHM1_11469,192,821 - 69,201,405 (-)NCBICHM1_1
T2T-CHM13v2.01462,994,521 - 63,003,244 (-)NCBIT2T-CHM13v2.0
Zfp36l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,154,534 - 80,159,787 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,154,528 - 80,159,787 (-)EnsemblGRCm39 Ensembl
GRCm381280,107,760 - 80,113,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,107,754 - 80,113,013 (-)EnsemblGRCm38mm10GRCm38
MGSCv371281,208,747 - 81,214,000 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,026,600 - 81,031,853 (-)NCBIMGSCv36mm8
Celera1281,572,651 - 81,577,898 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.46NCBI
Zfp36l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,663,396 - 104,669,815 (-)NCBIGRCr8
mRatBN7.2698,930,705 - 98,935,748 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,930,718 - 98,935,748 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx699,353,158 - 99,358,199 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,652,241 - 99,657,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,039,210 - 99,044,249 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,308,032 - 103,313,074 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,308,045 - 103,313,074 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06115,987,360 - 115,992,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,119,555 - 103,124,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16103,123,010 - 103,128,032 (-)NCBI
Celera697,294,425 - 97,299,423 (-)NCBICelera
Cytogenetic Map6q24NCBI
Zfp36l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,541,323 - 1,546,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554661,541,367 - 1,546,617 (+)NCBIChiLan1.0ChiLan1.0
ZFP36L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21569,902,452 - 69,911,122 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,118,962 - 69,127,451 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,372,058 - 49,379,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,247,341 - 68,255,805 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,247,347 - 68,255,805 (-)Ensemblpanpan1.1panPan2
Zfp36l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864062,140,623 - 62,145,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,045,377 - 12,051,536 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,045,679 - 12,050,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP36L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,490,017 - 92,495,554 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1792,490,069 - 92,495,864 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2798,803,589 - 98,809,023 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFP36L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,000,222 - 46,005,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2445,999,623 - 46,006,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605334,233,922 - 34,240,910 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfp36l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473432,251,114 - 32,257,211 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473432,251,100 - 32,256,458 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZFP36L1
53 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 5 12 8 10 6
Low 1
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000026141   ⟹   ENSCAFP00000024272
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl842,664,223 - 42,668,514 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006621   ⟹   ENSCAFP00845005268
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl842,893,325 - 42,898,755 (-)Ensembl
RefSeq Acc Id: XM_005623568   ⟹   XP_005623625
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1842,663,287 - 42,668,665 (-)NCBI
Dog10K_Boxer_Tasha842,352,777 - 42,358,311 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038483579   ⟹   XP_038339507
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1842,507,658 - 42,513,193 (-)NCBI
RefSeq Acc Id: XM_038545048   ⟹   XP_038400976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0842,941,809 - 42,947,345 (-)NCBI
RefSeq Acc Id: XM_038609156   ⟹   XP_038465084
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0842,582,437 - 42,587,961 (-)NCBI
RefSeq Acc Id: XM_038673970   ⟹   XP_038529898
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0842,893,323 - 42,898,832 (-)NCBI
RefSeq Acc Id: XP_005623625   ⟸   XM_005623568
- UniProtKB: A0A8C0SGM8 (UniProtKB/TrEMBL),   A0A8C0JWT3 (UniProtKB/TrEMBL),   A0A8I3MS54 (UniProtKB/TrEMBL),   A0A8P0SKI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024272   ⟸   ENSCAFT00000026141
RefSeq Acc Id: XP_038339507   ⟸   XM_038483579
RefSeq Acc Id: XP_038465084   ⟸   XM_038609156
RefSeq Acc Id: XP_038529898   ⟸   XM_038673970
- UniProtKB: A0A8C0SGM8 (UniProtKB/TrEMBL),   A0A8C0JWT3 (UniProtKB/TrEMBL),   A0A8I3MS54 (UniProtKB/TrEMBL),   A0A8P0SKI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400976   ⟸   XM_038545048
- UniProtKB: A0A8C0JWT3 (UniProtKB/TrEMBL),   A0A8C0SGM8 (UniProtKB/TrEMBL),   A0A8I3MS54 (UniProtKB/TrEMBL),   A0A8P0SKI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845005268   ⟸   ENSCAFT00845006621
Protein Domains
C3H1-type

Promoters
RGD ID:13684254
Promoter ID:EPDNEW_C2324
Type:multiple initiation site
Name:ZFP36L1_1
Description:ZFP36 ring finger protein like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1842,668,526 - 42,668,586EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016497 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015400 UniProtKB/TrEMBL
  ENSCAFG00040012969 UniProtKB/TrEMBL
  ENSCAFG00845003703 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026141.4 UniProtKB/TrEMBL
  ENSCAFT00000096663.1 UniProtKB/TrEMBL
  ENSCAFT00030028393.1 UniProtKB/TrEMBL
  ENSCAFT00040023950.1 UniProtKB/TrEMBL
  ENSCAFT00845006621 ENTREZGENE
  ENSCAFT00845006621.1 UniProtKB/TrEMBL
Gene3D-CATH Zinc finger, CCCH-type UniProtKB/TrEMBL
InterPro Tis11B_N UniProtKB/TrEMBL
  ZFP36-like UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/TrEMBL
KEGG Report cfa:490748 UniProtKB/TrEMBL
NCBI Gene ZFP36L1 ENTREZGENE
PANTHER MRNA DECAY ACTIVATOR PROTEIN ZFP36L1 UniProtKB/TrEMBL
  PTHR12547 UniProtKB/TrEMBL
Pfam Tis11B_N UniProtKB/TrEMBL
  zf-CCCH UniProtKB/TrEMBL
PROSITE ZF_C3H1 UniProtKB/TrEMBL
SMART ZnF_C3H1 UniProtKB/TrEMBL
Superfamily-SCOP SSF90229 UniProtKB/TrEMBL
UniProt A0A8C0JWT3 ENTREZGENE
  A0A8C0SGM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MS54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SKI7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48613 ENTREZGENE