TTC21A (tetratricopeptide repeat domain 21A) - Rat Genome Database

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Gene: TTC21A (tetratricopeptide repeat domain 21A) Canis lupus familiaris
Analyze
Symbol: TTC21A
Name: tetratricopeptide repeat domain 21A
RGD ID: 12201592
Description: INVOLVED IN flagellated sperm motility (inferred); intraciliary retrograde transport (inferred); protein localization to cilium (inferred); ASSOCIATED WITH genetic disease (ortholog); spermatogenic failure 37 (ortholog); FOUND IN cilium (inferred); intraciliary transport particle A (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tetratricopeptide repeat protein 21A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,776,252 - 8,812,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,781,582 - 8,811,031 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,816,088 - 8,848,339 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0239,065,036 - 9,097,061 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl239,065,022 - 9,097,060 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,878,708 - 8,910,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0239,020,973 - 9,053,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0239,014,406 - 9,046,449 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TTC21A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,776,252 - 8,812,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,781,582 - 8,811,031 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,816,088 - 8,848,339 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0239,065,036 - 9,097,061 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl239,065,022 - 9,097,060 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,878,708 - 8,910,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0239,020,973 - 9,053,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0239,014,406 - 9,046,449 (+)NCBIUU_Cfam_GSD_1.0
TTC21A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38339,107,680 - 39,138,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl339,107,680 - 39,138,903 (+)EnsemblGRCh38hg38GRCh38
GRCh37339,149,171 - 39,180,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,124,156 - 39,155,398 (+)NCBINCBI36Build 36hg18NCBI36
Build 34339,124,198 - 39,155,394NCBI
Celera339,089,656 - 39,120,906 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef339,191,073 - 39,222,318 (+)NCBIHuRef
CHM1_1339,100,229 - 39,131,478 (+)NCBICHM1_1
T2T-CHM13v2.0339,119,844 - 39,151,076 (+)NCBIT2T-CHM13v2.0
Ttc21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,766,656 - 119,798,496 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,766,672 - 119,796,859 (+)EnsemblGRCm39 Ensembl
GRCm389119,937,589 - 119,969,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,937,606 - 119,967,793 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,846,724 - 119,876,911 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,786,304 - 119,816,491 (+)NCBIMGSCv36mm8
Celera9120,404,834 - 120,435,102 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.33NCBI
Ttc21a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,544,684 - 128,580,464 (+)NCBIGRCr8
mRatBN7.28119,667,044 - 119,702,028 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,666,933 - 119,702,456 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08128,622,414 - 128,657,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,622,428 - 128,657,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,824,105 - 127,858,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,895,329 - 124,929,673 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,916,314 - 124,949,410 (+)NCBI
Celera8118,813,990 - 118,848,613 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ttc21a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,833,071 - 24,862,473 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,833,021 - 24,862,199 (-)NCBIChiLan1.0ChiLan1.0
TTC21A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2239,059,147 - 39,090,471 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1339,063,909 - 39,095,233 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0339,003,730 - 39,035,183 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1339,284,159 - 39,315,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,284,480 - 39,315,375 (+)Ensemblpanpan1.1panPan2
Ttc21a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118195,223,584 - 195,256,561 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,362,274 - 28,395,010 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,362,238 - 28,395,134 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTC21A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,797,518 - 23,830,332 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,797,518 - 23,830,334 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,057,100 - 26,090,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTC21A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115276,965 - 308,194 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15277,078 - 308,194 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660639,004,096 - 9,035,461 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttc21a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,844,152 - 1,873,273 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,844,044 - 1,873,398 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TTC21A
367 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 15 6 8 9
Low 5 5 7 6 6 6 6 1 6 1 6
Below cutoff 5

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014106493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038431923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038431924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038507237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038507238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038570479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038570480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038634656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038634657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000008176   ⟹   ENSCAFP00000007574
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl238,781,582 - 8,811,031 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060096   ⟹   ENSCAFP00000059072
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl238,781,582 - 8,811,031 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054263   ⟹   ENSCAFP00845042629
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl239,065,022 - 9,097,060 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054271   ⟹   ENSCAFP00845042637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl239,065,022 - 9,097,060 (+)Ensembl
RefSeq Acc Id: XM_038431923   ⟹   XP_038287851
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0239,065,036 - 9,097,061 (+)NCBI
RefSeq Acc Id: XM_038431924   ⟹   XP_038287852
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0239,065,170 - 9,097,061 (+)NCBI
RefSeq Acc Id: XM_038457274   ⟹   XP_038313202
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha238,816,088 - 8,848,339 (+)NCBI
RefSeq Acc Id: XM_038457275   ⟹   XP_038313203
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha238,816,222 - 8,848,339 (+)NCBI
RefSeq Acc Id: XM_038507237   ⟹   XP_038363165
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1238,878,708 - 8,910,708 (+)NCBI
RefSeq Acc Id: XM_038507238   ⟹   XP_038363166
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1238,878,842 - 8,910,708 (+)NCBI
RefSeq Acc Id: XM_038570479   ⟹   XP_038426407
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0239,014,406 - 9,046,449 (+)NCBI
RefSeq Acc Id: XM_038570480   ⟹   XP_038426408
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0239,014,540 - 9,046,449 (+)NCBI
RefSeq Acc Id: XM_038634656   ⟹   XP_038490584
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0239,020,973 - 9,053,234 (+)NCBI
RefSeq Acc Id: XM_038634657   ⟹   XP_038490585
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0239,021,107 - 9,053,234 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000059072   ⟸   ENSCAFT00000060096
RefSeq Acc Id: ENSCAFP00000007574   ⟸   ENSCAFT00000008176
RefSeq Acc Id: XP_038363165   ⟸   XM_038507237
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038363166   ⟸   XM_038507238
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038490584   ⟸   XM_038634656
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038490585   ⟸   XM_038634657
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038287851   ⟸   XM_038431923
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LNU9 (UniProtKB/TrEMBL),   A0A8C0Z2F0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038287852   ⟸   XM_038431924
- Peptide Label: isoform X2
- UniProtKB: A0A8C0Z299 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038313202   ⟸   XM_038457274
- Peptide Label: isoform X1
- UniProtKB: A0A8P0P845 (UniProtKB/TrEMBL),   A0A8C0Z2F0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038313203   ⟸   XM_038457275
- Peptide Label: isoform X2
- UniProtKB: A0A8C0Z299 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038426407   ⟸   XM_038570479
- Peptide Label: isoform X1
- UniProtKB: A0A8C0Z2F0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038426408   ⟸   XM_038570480
- Peptide Label: isoform X2
- UniProtKB: A0A8C0Z299 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845042629   ⟸   ENSCAFT00845054263
RefSeq Acc Id: ENSCAFP00845042637   ⟸   ENSCAFT00845054271


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005087 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011564 UniProtKB/TrEMBL
  ENSCAFG00040018966 UniProtKB/TrEMBL
  ENSCAFG00845030584 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008176.5 UniProtKB/TrEMBL
  ENSCAFT00000060096.2 UniProtKB/TrEMBL
  ENSCAFT00030021393.1 UniProtKB/TrEMBL
  ENSCAFT00030021560.1 UniProtKB/TrEMBL
  ENSCAFT00030021671.1 UniProtKB/TrEMBL
  ENSCAFT00030021751.1 UniProtKB/TrEMBL
  ENSCAFT00030021914.1 UniProtKB/TrEMBL
  ENSCAFT00040035905.1 UniProtKB/TrEMBL
  ENSCAFT00040036079.1 UniProtKB/TrEMBL
  ENSCAFT00040036288.1 UniProtKB/TrEMBL
  ENSCAFT00845054263.1 UniProtKB/TrEMBL
  ENSCAFT00845054271 ENTREZGENE
  ENSCAFT00845054271.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  TTC21A/TTC21B UniProtKB/TrEMBL
NCBI Gene TTC21A ENTREZGENE
PANTHER PTHR14699 UniProtKB/TrEMBL
  TETRATRICOPEPTIDE REPEAT PROTEIN 21A UniProtKB/TrEMBL
Pfam TPR_16 UniProtKB/TrEMBL
  TPR_19 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PROSITE TPR UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A8C0LNU9 ENTREZGENE
  A0A8C0MYU9_CANLF UniProtKB/TrEMBL
  A0A8C0MZ14_CANLF UniProtKB/TrEMBL
  A0A8C0MZ39_CANLF UniProtKB/TrEMBL
  A0A8C0NC85_CANLF UniProtKB/TrEMBL
  A0A8C0RHX9_CANLF UniProtKB/TrEMBL
  A0A8C0T461_CANLF UniProtKB/TrEMBL
  A0A8C0Z299 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z2F0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q4Q1_CANLF UniProtKB/TrEMBL
  A0A8I3QSF4_CANLF UniProtKB/TrEMBL
  A0A8P0P845 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SAN2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:47942 ENTREZGENE